Future directions for vaccine-based therapies

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

A survey of telomerase activity in human cancer

1997 • 2,747 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Matrix Metalloproteinases: Biologic Activity and Clinical Implications

2000 • 1,533 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Pro‐inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum‐free conditions

1997 • 1,179 citations

Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells

2000 • 1,175 citations

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

2003 • 1,132 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Natural selection of tumor variants in the generation of “tumor escape” phenotypes

2002 • 1,014 citations

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

2005 • 998 citations

T-cell priming by type-1and type-2 polarized dendritic cells: the concept of a third signal

1999 • 957 citations

Regulation of Dendritic Cell Migration to the Draining Lymph Node

2003 • 863 citations

Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species

2004 • 825 citations

The role of CD4+ T cell responses in antitumor immunity

1998 • 678 citations

Pivotal Phase III Trial of Two Dose Levels of Denileukin Diftitox for the Treatment of Cutaneous T-Cell Lymphoma

2001 • 612 citations

L-arginine metabolism in myeloid cells controls T-lymphocyte functions

2003 • 580 citations

A New Era for Cancer Immunotherapy Based on the Genes that Encode Cancer Antigens

1999 • 578 citations

Control of T‐cell activation by CD4⁺ CD25⁺ suppressor T cells

2001 • 560 citations

Certified Professionals

2001 • 533 citations

Rapid Induction of Tumor-specific Type 1 T Helper Cells in Metastatic Melanoma Patients by Vaccination with Mature, Cryopreserved, Peptide-loaded Monocyte-derived Dendritic Cells

2002 • 484 citations

Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.

2000 • 421 citations

Expression and function of OX40 ligand on human dendritic cells.

1997 • 416 citations

Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR

2005 • 406 citations

Engagement of the OX-40 Receptor In Vivo Enhances Antitumor Immunity

2000 • 386 citations

A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth

2002 • 375 citations

Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E2 regulates the migratory capacity of specific DC subsets

2002 • 369 citations

Telomerase mRNA-Transfected Dendritic Cells Stimulate Antigen-Specific CD8+ and CD4+ T Cell Responses in Patients with Metastatic Prostate Cancer

2005 • 352 citations

Derangement of immune responses by myeloid suppressor cells

2003 • 347 citations

Imiquimod, a Topical Immune Response Modifier, Induces Migration of Langerhans Cells11The authors have declared a conflict of interest.

2000 • 295 citations

Therapy of disseminated murine leukemia with cyclophosphamide and immune Lyt-1+,2- T cells. Tumor eradication does not require participation of cytotoxic T cells.

1985 • 295 citations

Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination

2005 • 282 citations

Immunity to cancer: attack and escape in T lymphocyte–tumor cell interaction

2002 • 280 citations

Cytokine induction by the immunomodulators imiquimod and S-27609

1995 • 268 citations

Vaccination of Cancer Patients Against Telomerase Induces Functional Antitumor CD8+ T Lymphocytes

2004 • 254 citations

Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine

2000 • 236 citations

Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity.

2003 • 185 citations

Dendritic cells and immune-based therapies.

1996 • 180 citations

The molecular program induced in T cells undergoing homeostatic proliferation

2004 • 176 citations

Injection of Immature Dendritic Cells into Adjuvant-Treated Skin Obviates the Need for Ex Vivo Maturation

2003 • 168 citations

Synergy between tumor immunotherapy and antiangiogenic therapy

2003 • 167 citations

Active Immunization Against the Vascular Endothelial Growth Factor Receptor flk1 Inhibits Tumor Angiogenesis and Metastasis

2002 • 156 citations

Effective immunotherapy against cancer

2004 • 145 citations

Role of Ox40 Signals in Coordinating Cd4 T Cell Selection, Migration, and Cytokine Differentiation in T Helper (Th)1 and Th2 Cells

2000 • 143 citations

Cancer immunotherapy: breaking the barriers to harvest the crop

2004 • 137 citations

The antigen dose determines T helper subset development by regulation of CD40 ligand

2000 • 134 citations

Analysis of the major histocompatibility complex class I antigen presentation machinery in normal and malignant renal cells: evidence for deficiencies associated with transformation and progression.

1996 • 123 citations

Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand

2004 • 118 citations

Enhanced induction of telomerase-specific CD4(+) T cells using dendritic cells transfected with RNA encoding a chimeric gene product.

2002 • 118 citations

Generation of Cytotoxic Responses in Mice and Human Individuals Against Hematological Malignancies Using Survivin-RNA-Transfected Dendritic Cells

2003 • 108 citations

Deficient Cellular Immunity--Finding and Fixing the Defects

1999 • 106 citations

Expression of the Survivin Gene in Prostate Cancer: Correlation With Clinicopathological Characteristics, Proliferative Activity and Apoptosis

2004 • 98 citations

Negative Regulation of T-Cell Function by PD-1

2004 • 93 citations

Costimulatory wars: the tumor menace

2000 • 78 citations

Complementary Role of CD4+ T Cells and Secondary Lymphoid Tissues for Cross-presentation of Tumor Antigen to CD8+ T Cells

2003 • 76 citations

Active immunogene therapy of cancer with vaccine on the basis of chicken homologous matrix metalloproteinase-2.

2003 • 63 citations

What's new in the treatment of advanced prostate cancer?

2002 • 30 citations

Antigenic targets for renal cell carcinoma immunotherapy

2004 • 27 citations

EXPRESSION AND IMMUNOGENICITY OF ONCOFETAL ANTIGEN-IMMATURE LAMININ RECEPTOR IN HUMAN RENAL CELL CARCINOMA

2001 • 26 citations

Technology Insight: vaccine therapy for prostate cancer

2005 • 23 citations