p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Cancer Statistics, 2002

2002 • 2,954 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

2001 • 2,226 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

2004 • 1,977 citations

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

2001 • 1,672 citations

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

2003 • 1,298 citations

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

2001 • 1,275 citations

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

2001 • 960 citations

Apoptosis and melanoma chemoresistance

2003 • 806 citations

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1

2003 • 771 citations

Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides

1997 • 698 citations

Intracellular Regulation of TRAIL-Induced Apoptosis in Human Melanoma Cells

1998 • 671 citations

Integral role of Noxa in p53-mediated apoptotic response

2003 • 326 citations

Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents

2003 • 313 citations

The genetics of malignant melanoma: lessons from mouse and man

2003 • 289 citations

Experimental co-expression of vimentin and keratin intermediate filaments in human breast cancer cells results in phenotypic interconversion and increased invasive behavior.

1997 • 274 citations

Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim

2001 • 270 citations

Protein Kinase Cδ Is Activated by Caspase-dependent Proteolysis during Ultraviolet Radiation-induced Apoptosis of Human Keratinocytes

1998 • 230 citations

Secretase Targets for Alzheimer's Disease: Identification and Therapeutic Potential

2001 • 136 citations

Transendothelial function of human metastatic melanoma cells: role of the microenvironment in cell-fate determination.

2002 • 119 citations

Recent advances in the development of gamma-secretase inhibitors.

2002 • 43 citations