Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

Gain of function mutations in p53

1993 • 876 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.

1990 • 607 citations

Cellular accumulation of the anticancer agent cisplatin: A review

1993 • 557 citations

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

1994 • 410 citations

Activation of programmed cell death by anticancer agents: cisplatin as a model system.

1990 • 408 citations

Cellular pharmacology of cisplatin: perspectives on mechanisms of acquired resistance.

1990 • 393 citations

Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis.

1994 • 377 citations

Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland.

1993 • 375 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines

1991 • 262 citations

A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress

1994 • 221 citations

Mutant conformation of p53

1992 • 214 citations

Increased accumulation of p53 protein in cisplatin‐resistant ovarian cell lines

1993 • 203 citations

To pop or not to pop: p53 as a critical modulator of tumour responsiveness to therapy in vivo?

1995 • 168 citations

Relationship of p53 to the control of apoptotic cell death.

1994 • 163 citations

The role of apoptosis in cell killing by cisplatin: a flow cytometric study

1994 • 141 citations

Cisplatin resistance in human cancers

1991 • 96 citations

Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development.

1994 • 96 citations

[26] Nuclear retinoic acid receptors: Cloning, analysis, and function

1990 • 73 citations

The role of p53 in tumor progression.

1994 • 28 citations

Specific repression of granulocyte-macrophage and granulocyte colony- stimulating factor gene expression in interleukin-1-stimulated endothelial cells with antisense oligodeoxynucleotides

1992 • 27 citations

Platinum analogues in preclinical and clinical development

1993 • 14 citations

p53: A target for new anticancer drugs or a target for old drugs?

1993 • 5 citations