p53 Gene Mutations in Chinese Human Testicular Seminoma

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Hereditary cancer, oncogenes, and antioncogenes.

1985 • 1,261 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.

1990 • 607 citations

Tumor suppressor p53: analysis of wild-type and mutant p53 complexes.

1991 • 242 citations

Oncogenes and Tumor-Suppressing Genes

1988 • 222 citations

Loss of chromosome 17p13 sequences and mutation of p53 in human breast carcinomas.

1991 • 200 citations

Mutant p53 proteins bind hsp 72/73 cellular heat shock-related proteins in SV40-transformed monkey cells.

1987 • 162 citations

Cytogenetic and molecular analysis of human male germ cell tumors: Chromosome 12 abnormalities and gene amplification

1990 • 162 citations

Oligomerization of oncoprotein p53

1988 • 158 citations

p53 Protein alterations in human testicular cancer including pre‐invasive intratubular germ‐cell neoplasia

1991 • 133 citations

Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer.

1990 • 127 citations

Molecular mechanisms of oncogenesis.

1989 • 84 citations

Activated ras genes in human seminoma: evidence for tumor heterogeneity.

1989 • 53 citations

EXPRESSION OF MYC FAMILY ONCOGENES IN PRIMARY HUMAN TESTICULAR CANCER

1989 • 7 citations

Frequent Occurrence of Activated ras Oncogenes in Seminomas but Not in Nonseminomatous Germ Cell Tumors

1991 • 5 citations