Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

Improved Fourier coefficients for maps using phases from partial structures with errors

1986 • 1,897 citations

A graphics model building and refinement system for macromolecules

1978 • 1,858 citations

Evaluation of single-crystal X-ray diffraction data from a position-sensitive detector

1988 • 1,516 citations

Current Topics in Membranes and Transport

1970 • 1,240 citations

Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system

1978 • 902 citations

An efficient general-purpose least-squares refinement program for macromolecular structures

1987 • 871 citations

Current topics in membranes and transport

1976 • 847 citations

Using known substructures in protein model building and crystallography.

1986 • 766 citations

Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development

1983 • 645 citations

Surface, subunit interfaces and interior of oligomeric proteins

1988 • 644 citations

The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein.

1986 • 533 citations

Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution.

1986 • 517 citations

Crystal orientation and X-ray pattern prediction routines for area-detector diffractometer systems in macromolecular crystallography

1987 • 396 citations

Mechanism of action of choleragen. Evidence for ADP-ribosyltransferase activity with arginine as an acceptor.

1977 • 391 citations

The three-dimensional structure of ricin at 2.8 A.

1987 • 382 citations

FIELD TRIAL OF ORAL CHOLERA VACCINES IN BANGLADESH

1986 • 353 citations

The arrangement of subunits in chlorea toxin

1976 • 337 citations

Amino acid sequence homology between cholera toxin and Escherichia coli heat-labile toxin

1980 • 328 citations

Nucleotide sequence of the structural gene for diphtheria toxin carried by corynebacteriophage beta.

1983 • 307 citations

Cloning, nucleotide sequence, and expression in Escherichia coli of the exotoxin A structural gene of Pseudomonas aeruginosa.

1984 • 286 citations

Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues

1989 • 252 citations

Enzymic activity of cholera toxin. II. Relationships to proteolytic processing, disulfide bond reduction, and subunit composition.

1979 • 230 citations

Active site of Pseudomonas aeruginosa exotoxin A. Glutamic acid 553 is photolabeled by NAD and shows functional homology with glutamic acid 148 of diphtheria toxin.

1987 • 213 citations

Three-Dimensional Structure of Cholera Toxin Penetrating a Lipid Membrane

1988 • 166 citations

Mechanism of toxin secretion by Vibrio cholerae investigated in strains harboring plasmids that encode heat-labile enterotoxins of Escherichia coli.

1984 • 147 citations

Heavy riboflavin synthase from Bacillus subtilis

1988 • 145 citations

Role of Prostaglandins and cAMP in the Secretory Effects of Cholera Toxin

1989 • 133 citations

Adenosine Diphosphate-Ribosylation of Adenylate Cyclase Catalyzed by Heat-Labile Enterotoxin of Escherichia coli: Comparison with Cholera Toxin

1980 • 128 citations

Structure, stability, and receptor interaction of cholera toxin as studied by Fourier-transform infrared spectroscopy

1990 • 118 citations

Exotoxin A of Pseudomonas aeruginosa: substitution of glutamic acid 553 with aspartic acid drastically reduces toxicity and enzymatic activity

1987 • 115 citations

Comparison of heat-labile enterotoxins from porcine and human strains of Escherichia coli

1982 • 114 citations

The complete nucleotide sequence of the gene coding for diphtheria toxin in the corynephage omega (tox⁺) genome

1983 • 110 citations

Evolutionary origin of pathogenic determinants in enterotoxigenic Escherichia coli and Vibrio cholerae O1

1987 • 109 citations

A reciprocal-space method for calculating a molecular envelope using the algorithm of B.C. Wang

1987 • 104 citations

Escherichia coli heat-labile enterotoxin. Nucleotide sequence of the A subunit gene.

1982 • 104 citations

Photolabelling of cholera toxin subunits during membrane penetration

1981 • 99 citations

Lipid insertion of cholera toxin after binding to GM1-containing liposomes.

1981 • 87 citations

Thermal stability and intersubunit interactions of cholera toxin in solution and in association with its cell-surface receptor ganglioside GM1

1988 • 81 citations

Chemical and immunochemical studies on the receptor binding domain of cholera toxin B subunit.

1985 • 79 citations

Testing the method of crystallographic refinement using molecular dynamics

1989 • 79 citations

Genetic fusion of a non‐toxic heat‐stable enterotoxin‐related decapeptide antigen to cholera toxin B‐subunit

1988 • 78 citations

Tryptophan residues of cholera toxin and its A and B protomers. Intrinsic fluorescence and solute quenching upon interacting with the ganglioside GM1, oligo-GM1, or dansylated oligo-GM1.

1981 • 76 citations

Analysis of receptor-binding site in Escherichia coli enterotoxin.

1985 • 76 citations

A single amino acid substitution in the A subunit of Escherichia coli enterotoxin results in a loss of its toxic activity.

1990 • 73 citations

Cholera toxin B-subunit gene fusion: structural and functional analysis of the chimeric protein

1990 • 70 citations

Escherichia coli heat-labile enterotoxin. Ganglioside specificity and ADP-ribosyltransferase activity.

1981 • 69 citations

Alterations at the carboxyl terminus change assembly and secretion properties of the B subunit of Escherichia coli heat-labile enterotoxin

1987 • 63 citations

A single amino acid substitution in the A subunit of Escherichia coli enterotoxin results in a loss of its toxic activity.

1990 • 60 citations

Mapping the enzymatic active site of Pseudomonas aeruginosa exotoxin A

1988 • 58 citations

Immunochemical and Molecular Genetic Analysis of Bacterial Pathogens

1988 • 55 citations

Escherichia coli heat-labile enterotoxin. Ganglioside specificity and ADP-ribosyltransferase activity.

1981 • 52 citations

ADP-ribosylation by cholera toxin: functional analysis of a cellular system that stimulates the enzymic activity of cholera toxin fragment A1

1987 • 49 citations

Kinetics of synthesis, processing, and membrane transport of heat-labile enterotoxin, a periplasmic protein in Escherichia coli.

1984 • 48 citations

Cloning, nucleotide sequence, and hybridization studies of the type IIb heat-labile enterotoxin gene of Escherichia coli

1989 • 47 citations

Inactivation of the Escherichia coli heat‐labile enterotoxin by in vitro mutagenesis of the A‐subunit gene

1989 • 44 citations

Construction of a plasmid for expression of foreign epitopes as fusion proteins with subunit B of Escherichia coli heat-labile enterotoxin

1989 • 42 citations

ADP-Ribosylating Microbial Toxins

1984 • 41 citations

Priming immunization against cholera toxin and E. coli heat-labile toxin by a cholera toxin short peptide-beta-galactosidase hybrid synthesized in E. coli.

1985 • 40 citations

X-Ray Diffraction Studies of the Cholera Toxin receptor, GM1

1986 • 38 citations

Binding of NAD+ by cholera toxin

1987 • 35 citations

Pseudomonas aeruginosa exotoxin A: effects of mutating tyrosine-470 and tyrosine-481 to phenylalanine

1988 • 34 citations

Subunit arrangement of cholera toxin in solution and bound to receptor-containing model membranes

1982 • 34 citations

Heat-labile enterotoxin of Escherichia coli. Characterization of different crystal forms.

1985 • 32 citations

Heat-labile enterotoxin of Escherichia coli. Characterization of different crystal forms.

1985 • 28 citations

Effect of substitution of glycine for arginine at position 146 of the A1 subunit on biological activity of Escherichia coli heat-labile enterotoxin

1988 • 25 citations

A Single Amino Acid Substitution in B Subunit of Escherichia coli Enterotoxin Affects Its Oligomer Formation

1989 • 24 citations

Location and amino acid sequence around the ADP-ribosylation site in the cholera toxin active subunit A1

1983 • 20 citations