Poly(ADP-ribose)polymerase: a perplexing participant in cellular responses to DNA breakage

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

1986 • 520 citations

Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure.

1982 • 499 citations

Poly(ADP-ribose) synthesis in vitro programmed by damaged DNA. A comparison of DNA molecules containing different types of strand breaks.

1980 • 488 citations

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.

1986 • 466 citations

ADP-ribosylation in mammalian cell ghosts. Dependence of poly(ADP-ribose) synthesis on strand breakage in DNA.

1980 • 378 citations

Regulation of DNA ligase activity by poly(ADP-ribose)

1982 • 369 citations

DNA strand breaks, NAD metabolism, and programmed cell death

1986 • 303 citations

Inhibitors of Poly(Adenosine Diphosphate-Ribose) Synthesis: Effect on Other Metabolic Processes

1984 • 241 citations

Inhibitors of poly(adenosine diphosphate ribose) polymerase induce sister chromatid exchanges

1980 • 236 citations

Poly (ADP-Ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain.

1984 • 226 citations

ADP-Ribose in DNA Repair: A New Component of DNA Excision Repair

1984 • 226 citations

Association of Poly(Adenosine Diphosphoribose) Synthesis with DNA Damage and Repair in Normal Human Lymphocytes

1979 • 222 citations

Poly(ADP-ribose) synthetase, a main acceptor of poly(ADP-ribose) in isolated nuclei.

1981 • 198 citations

Modulation of chromatin superstructure induced by poly(ADP-ribose) synthesis and degradation.

1986 • 197 citations

The Enhancement of Cytotoxicity of N‐Methyl‐N‐nitrosourea and of y‐Radiation by Inhibitors of Poly(ADP‐ribose) Polymerase

1980 • 196 citations

Poly(ADP-ribose) polymerase inhibitors preserve oxidized nicotinamide adenine dinucleotide and adenosine 5'-triphosphate pools in DNA-damaged cells: mechanism of stimulation of unscheduled DNA synthesis

1983 • 195 citations

Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA

1989 • 192 citations

Poly(adenosinediphosphoribose) polymerase inhibitors stimulate unscheduled DNA synthesis in normal human lymphocytes

1982 • 181 citations

cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase.

1987 • 181 citations

Poly(ADP-ribosylation) of DNA topoisomerase I from calf thymus.

1984 • 178 citations

Evidence for adenosine diphosphate ribosylation of Ca2+, Mg2+-dependent endonuclease.

1975 • 166 citations

Purification and analysis of a factor which suppresses nick-induced transcription by RNA polymerase II and its identity with poly(ADP-ribose) polymerase.

1983 • 159 citations

Role of poly(adenosine diphosphate ribose) in deoxyribonucleic acid repair in human fibroblasts

1982 • 153 citations

ADP-Ribosylation Reactions

1982 • 152 citations

Structure of poly(adenosine diphosphate ribose): identification of 2'-[1''-ribosyl-2''-(or 3''-)(1'''-ribosyl)]adenosine-5',5'',5'''-tris(phosphate) as a branch linkage.

1979 • 149 citations

Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase

1987 • 149 citations

Effects of altered [ADP-ribose]n metabolism on expression of fetal functions by adult hepatocytes

1982 • 144 citations

ADP-ribosylation of nuclear proteins in vivo. Identification of histone H2B as a major acceptor for mono- and poly(ADP-ribose) in dimethyl sulfate-treated hepatoma AH 7974 cells.

1984 • 141 citations

Oxidant injury of cells.

1987 • 135 citations

Primary structure of human poly(ADP-ribose) synthetase as deduced from cDNA sequence.

1987 • 127 citations

Inhibition of calf thymus type II DNA topoisomerase by poly(ADP-ribosylation).

1985 • 126 citations

Contribution of incorporated 5-bromodeoxyuridine in DNA to the frequencies of sister-chromatid exchanges induced by inhibitors of poly-(ADP-ribose)-polymerase

1981 • 117 citations

Differences in the regulation by poly(ADP-ribose) of repair of DNA damage from alkylating agents and ultraviolet light according to cell type.

1983 • 116 citations

Poly(ADP-ribose)polymerase: a novel finger protein

1989 • 116 citations

Inhibition of DNA polymerase α, DNA polymerase β, terminal deoxynucleotidyl transferase, and DNA ligase II by poly(ADP-ribosyl)ation reaction in vitro

1985 • 111 citations

Modification of SV40 T antigen by poly ADP-ribosylation

1981 • 110 citations

Inhibition of malignant transformation in vitro by inhibitors of poly(ADP-ribose) synthesis.

1984 • 109 citations

ADP-Ribosylation of Proteins

1985 • 109 citations

3-Aminobenzamide synergistically increases sister-chromatid exchanges in cells exposed to methyl methanesulfonate but not to ultraviolet light

1982 • 107 citations

Effect of 3-aminobenzamide on DNA strand-break rejoining and cytotoxicity in CHO cells treated with hydrogen peroxide

1986 • 104 citations

ADP-ribose transfer reactions : mechanisms and biological significance

1989 • 103 citations

Cloning and expression of cDNA for human poly(ADP-ribose) polymerase.

1987 • 97 citations

The branching and linear portions of poly(adenosine diphosphate ribose) have the same alpha(1 leads to 2) ribose-ribose linkage.

1981 • 94 citations

Proteins Involved in DNA Replication

1984 • 91 citations

Inhibitors of poly-(adenosine diphosphoribose) synthesis slow the resealing rate of x-ray-induced DNA strand breaks

1982 • 87 citations

At least 60 ADP-ribosylated variant histones are present in nuclei from dimethylsulfate-treated and untreated cells.

1988 • 86 citations

Repair of potentially lethal lesions in x-irradiated, density-inhibited Chinese hamster cells: metabolic effects and hypoxia.

1973 • 86 citations

Nicotinamide stimulates repair of DNA damage in human lymphocytes

1980 • 86 citations

Cell cycle-dependent intervention by benzamide of carcinogen-induced neoplastic transformation and in vitro poly(ADP-ribosyl)ation of nuclear proteins in human fibroblasts.

1983 • 77 citations

Sequential ADP‐ribosylation pattern of nucleosomal histones

1985 • 77 citations

Poly(ADP-ribose)-mediated post-translational modification of chromatin-associated human topoisomerase I

1989 • 76 citations

Poly(adenosine diphosphate-ribose) polymerase: the distribution of a chromosome-associated enzyme within the chromatin substructure

1977 • 76 citations

Effect of 3-aminobenzamide on the rate of ligation during repair of alkylated DNA in human fibroblasts.

1983 • 69 citations

X-ray induction of methotrexate resistance due todhfr gene amplification

1990 • 68 citations

Release of core DNA from nucleosomal core particles following (ADP-ribose)n-modification invitro

1987 • 68 citations

[52] Poly(ADP-ribose) synthetase

1984 • 68 citations

Poly(ADP-Ribose) and the Response of Cells to Ionizing Radiation

1985 • 67 citations

Nuclear protein modification and chromatin substructure. 2. Internucleosomal localization of poly(adenosine diphosphate-ribose) polymerase

1978 • 61 citations

Endogenous ADP ribosylation of high mobility group proteins 1 and 2 and histone H1 following DNA damage in intact cells

1985 • 61 citations

High incidence of sister chromatid exchanges and chromatid interchanges in the conditions of lowered activity of poly(ADP-ribose)polymerase

1981 • 59 citations

Inhibitors of poly(ADP-ribose) polymerase enhance unscheduled DNA synthesis in human peripheral lymphocytes

1981 • 58 citations

DNA strand breaks alter histone ADP-ribosylation.

1989 • 58 citations

Enhancement of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA amplification in a Simian virus 40-transformed Chinese hamster cell line by 3-aminobenzamide.

1987 • 57 citations

Poly ADP-Ribosylation of Proteins

1989 • 56 citations

Prevention of tumorigenesis of oncogene-transformed rat fibroblasts with DNA site inhibitors of poly(ADP ribose) polymerase.

1987 • 56 citations

Probable helical conformation of poly(ADP-ribose). The effect of cations on spectral properties.

1983 • 55 citations

Inhibitors of poly(ADP-ribose) synthesis enhance X-ray killing of log-phase Chinese hamster cells.

1984 • 54 citations

Molecular cloning of cDNA for human poly(ADP-ribose) polymerase and expression of its gene during HL-60 cell differentiation

1987 • 54 citations

Involvement of Poly (ADP-ribose) in the Radiation Response of Mammalian Cells

1984 • 52 citations

Inhibition of prolyl hydroxylase by poly(ADP-ribose) and phosphoribosyl-AMP

1989 • 51 citations

Cellular recovery of dividing and confluent C3H10T1/2 cells from N-methyl-N′-nitro-N-nitrosoguanidine in the presence of ADP ribosylation inhibitors

1985 • 51 citations

Poly(ADP-ribose) synthesis is involved in the toxic effects of alkylating agents but does not regulate DNA repair

1985 • 51 citations

Repair of Potentially Lethal Lesions in X-Irradiated, Density-Inhibited Chinese Hamster Cells: Metabolic Effects and Hypoxia

1973 • 50 citations

The influence of inhibitors of poly (ADP-ribose) polymerase on X-ray-induced potentially lethal damage repair.

1984 • 50 citations

Cell cycle perturbations following DNA damage in the presence of ADP-ribosylation inhibitors

1985 • 50 citations

Inhibitors of poly (ADP-ribose) synthesis enhance radiation response by differentially affecting repair of potentially lethal versus sublethal damage.

1984 • 49 citations

Disturbances in DNA precursor metabolism associated with exposure to an inhibitor of poly(ADP-ribose) synthetase

1986 • 49 citations

Induction of sister chromatid exchanges by nicotinamide in Chinese hamster lung fibroblasts and human lymphoblastoid cells

1979 • 49 citations

Expression of the poly(ADP-ribose) polymerase gene following natural and induced DNA strand breakage and effect of hyperexpression on DNA repair

1990 • 48 citations

Time course of polynucleosome relaxation and ADP‐ribosylation

1985 • 48 citations

Effects of 3-aminobenzamide on DNA synthesis and cell cycle progression in Chinese hamster ovary cells

1983 • 47 citations

Radiosensitization of Human Fibroblasts by 3-Aminobenzamide: An Inhibitor of Poly(ADP-Ribosylation)

1985 • 46 citations

Inhibitors of poly(ADP‐ribose) polymerase enhance DNA strand breaks, excision repair, and sister chromatid exchanges induced by alkylating agents

1983 • 44 citations

Potentiation of cell killing by inhibitors of poly(adenosine diphosphate-ribose) synthesis in bleomycin-treated Chinese hamster ovary cells.

1985 • 40 citations

In vitro poly(ADP-ribosyl)ation of seminal ribonuclease.

1986 • 40 citations

A comparison of the toxic and SCE-inducing effects of inhibitors of ADP-ribosyl transferase in Chinese hamster ovary cells

1984 • 39 citations

Poly(ADP-ribose) polymerase forms loops with DNA

1987 • 39 citations

Sensitization of normal and malignant tissues to cyclophosphamide by nitroimidazoles with different partition coefficients

1984 • 38 citations

Inhibitors of Poly(ADP-Ribose) Synthesis Enhance X-Ray Killing of Log-Phase Chinese Hamster Cells

1984 • 37 citations

Immunofluorescent staining of poly(ADP-ribose) in situ in HeLa cell chromosomes in the M phase.

1981 • 35 citations

Inhibition of carcinogen‐induced cellular transformation of human fibroblasts by drugs that interact with the poly(ADP‐ribose) polymerase system

1985 • 35 citations

Carcinogen induced asynchronous replication of polyoma DNA is mediated by a trans-acting factor

1986 • 34 citations

Association of poly(adenosine diphosphate ribosylated) nucleosomes with transcriptionally active and inactive regions of chromatin

1984 • 34 citations

3‐Aminobenzamide is lethal to MMS‐damaged human fibroblasts primarily during s phase

1984 • 32 citations

Effect of 3-aminobenzamide on the induction of toxicity and transformation by ethyl methanesulfonate and methylcholanthrene in BALB/3T3 cells

1984 • 32 citations

Increased repair replication in human lymphoid cells by inhibition of polyadenosine diphosphoribose synthesis with no increase in patch sizes.

1985 • 31 citations

Direction of elongation of poly(ADP-ribose) chains. Addition of residues at the polymerase-proximal terminus.

1987 • 31 citations

Relationship between DNA strand breaks and inhibition of poly(ADP-ribosylation): enhancement of carcinogen-induced transformation

1986 • 30 citations

Poly(ADP-ribosyl)ation of RNA polymerase II from wheat germ

1985 • 30 citations

Induction of sister chromatid exchange by 3-aminobenzamide is independent of bromodeoxyuridine

1984 • 30 citations

Comutagenic effects of 3-aminobenzamide in Chinese hamster ovary cells.

1985 • 29 citations

ADP-ribosylation and post-irradiation cellular recovery in two strains of L5178Y cells.

1984 • 29 citations

Excision-repair patch size in DNA from human KB cells treated with UV-light, or methyl methanesulfonate

1982 • 28 citations

Selective isolation of domains of chromatin proximal to both carcinogen-induced DNA damage and poly-adenosine diphosphate-ribosylation.

1985 • 27 citations

Enhanced ligation of repair sites under conditions of inhibition of poly(ADP-ribose) synthesis by 3-aminobenzamide

1986 • 26 citations

Effects of 5-methylnicotinamide on mouse L1210 cells exposed to N-methyl-N-nitrosourea: mutation induction, formation and removal of methylation products in DNA, and unscheduled DNA synthesis

1981 • 25 citations

3-Aminobenzamide, an inhibitor of poly(ADP-ribose) polymerase, is a stimulator, not an inhibitor, of DNA repair

1987 • 25 citations

Acceptors for the poly ADP-ribosylation modification of chromatin structure are altered by carcinogen-induced DNA damage

1982 • 25 citations

Evidence for a novel metabolic pathway of (ADP-ribose)N: Pyrophosphorolysis of ADP-ribose in HeLa S3 cell nuclei

1989 • 25 citations

Delayed Repair of DNA Single-strand Breaks Does Not Increase Cytogenetic Damage

1985 • 24 citations

Inhibition of poly(ADP‐ribose) polymerase causes increased DNA strand breaks without decreasing strand rejoining in alkylated HeLa cells

1985 • 23 citations

Post-irradiation sensitization with the ADP-ribosyltransferase inhibitor 3-acetamidobenzamide.

1984 • 21 citations

Different efficiencies of interaction between 3-aminobenzamide and various monofunctional alkylating agents in the induction of sister chromatid exchanges

1985 • 21 citations

Expression of human poly(ADP-ribose) polymerase with DNA-dependent enzymatic activity inEscherichia coli

1989 • 20 citations

Spontaneous and 3-aminobenzamide-induced sister-chromatid exchange frequencies estimated by ring chromosome analysis

1986 • 19 citations

3-Aminobenzamide does not increase repair patch size in mammalian cells

1984 • 18 citations

Comparison of ADP-ribosylation of chromosomal proteins between intact and broken cells

1985 • 18 citations

Potentiation of alkylation-induced sister chromatid exchange frequency by 3-aminobenzamide is mediated by intracellular loss of NAD⁺

1986 • 18 citations

Suppression of N-methyl-N′-nitro-N-nitrosoguanidine-induced mutation in Chinese hamster V79 cells by inhibition of poly(ADP-ribose)polymerase activity

1983 • 18 citations

Poly ADP-ribosylation of histones in tumor promoter phorbol-12-myristate-13-acetate treated mouse embryo fibroblasts C3H10T12

1985 • 17 citations

DNA repair patch size measurements with nucleosomal DNA

1983 • 17 citations

Methylating and ethylating carcinogens have different requirements for poly(ADP-ribose) synthesis during malignant transformation

1984 • 17 citations

Inhibition of X-Ray- and Ultraviolet Light-Induced Transformation in Vitro by Modifiers of Poly(ADP-Ribose) Synthesis

1984 • 16 citations

Poly (ADP-ribose) is not involved in the rejoining of DNA breaks accumulated to high levels in u.v.-irradiated HeLa cells

1985 • 16 citations

Antagonistic action of a tumor promoter and a poly(adenosine di phosphoribose) synthesis inhibitor in radiation-induced transformation in vitro

1986 • 16 citations

Possible participation of Ca2+, Mg2+-dependent endonuclease in liver DNA fragmentation after N-methyl-N-nitrosourea treatment

1984 • 15 citations

3-Aminobenzamide does not affect X-ray-induced cytogenetic damage in G0 human lymphocytes

1986 • 14 citations

Cell cycle-dependent potentiation of X-ray-induced chromosomal aberrations by 3-Aminobenzamide

1987 • 13 citations

Effects of 3-aminobenzamide on the induction of morphologic transformation by diverse compounds Balb/3T3 cells in vitro

1986 • 13 citations

Chromatin dynamics. Fast and slow modes of nucleosome movement revealed through psoralen binding and repair

1985 • 13 citations

Preferential binding of benzo[a]pyrene diol epoxide to the linker DNA of human foreskin fibroblasts in S phase in the presence of benzamide.

1985 • 13 citations

Expression of functional zinc finger domain of human poly(ADP-ribose)polymerase inE.coly

1989 • 12 citations

Poly (ADP-Ribosylation) and DNA Topoisomerase I in Different Cell Lines

1984 • 11 citations

Alterations in transformation efficiency by the ADPRT-inhibitor 3-aminobenzamide are oncogene specific

1989 • 10 citations

DNA ligation and changes in chromatin structure associated with repair patches under conditions of inhibition of poly (ADP-ribose) synthesis

1986 • 10 citations

Influence of inhibitors of poly(ADP-ribose)polymerase activity on X-ray and ultraviolet light induced killing and mutation in Chinese hamster V79 cells

1986 • 10 citations

Potentiation of sister chromatid exchange by 3‐aminobenzamide is not modulated by topoisomerases or proteases

1986 • 9 citations

Antipain‐mediated suppression of sister chromatid exchanges induced by an inhibitor of poly (ADP‐ribose) polymerase

1985 • 9 citations

Independent induction of sister-chromatid exchanges by 3-aminobenzamide and ultraviolet radiation in HeLa cells

1983 • 8 citations

Mutation frequencies from X-rays, ultraviolet light, and methyl methanesulfonate in Chinese hamster ovary cells incubated with 3-aminobenzamide

1986 • 8 citations

The Poly-ADP-Ribosylation System of Higher Eukaryotes: How Can It Do What?

1990 • 8 citations

DNA-Poly(ADP-Ribose) Polymerase Complex: Isolation of the DNA Wrapping the Enzyme Molecule

1985 • 8 citations

The differential effect of benzamide upon the toxicity and mutations produced in Chinese hamster ovary cells by N-methyl nitrosourea, N-ethyl nitrosourea and N-hydroxy-2-aminofluorene

1985 • 7 citations

Differential induction of indirect DNA breaks but no inhibition of strand-break ligation of alkylated DNA by 3-aminobenzamide in human and C3H 10T1/2 cells.

1987 • 7 citations

Critical biochemical and regulatory events in malignant transformation in vitro.

1983 • 7 citations

Differences in the stimulation of repair replication by 3-aminobenzamide in lymphoblastoid cells damaged by methylmethanesulfonate or ultraviolet light

1987 • 5 citations

Advances in Mutagenesis Research

1990 • 4 citations

Poly-ADP-ribosylation is not required for excision of a DNA damage

1983 • 3 citations

Prevention of tumorigenesis of oncogene-transformed rat fibroblasts with DNA site inhibitors of poly(ADP ribose) polymerase

1987 • 3 citations

Benzamide prevention of ultraviolet radiation‐induced transformation as measured by anchorage‐independent growth and the absence of correlation with thymidine dimer formation and DNA repair

1989 • 1 citations

Rearrangement of mammalian chromatin structure following excision repair: absence of an effect of inhibitors of poly (ADP-ribose) polymerase and topoisomerase.

1985 • 1 citations

Cited By (0)

Loading...