Tumor Rejection by Disturbing Tumor Stroma Cell Interactions

Inflammation and cancer

2002 • 14,174 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Inflammation. Basic principles and clinical correlates

1989 • 2,424 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.

2000 • 1,536 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

The origin and function of tumor-associated macrophages

1992 • 1,081 citations

Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice

1999 • 990 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.

1982 • 640 citations

Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFNγ receptors

1994 • 619 citations

Murine Macrophages Secrete Interferon γ upon Combined Stimulation with Interleukin (IL)-12 and IL-18: A Novel Pathway of Autocrine Macrophage Activation

1998 • 594 citations

CD4 + T Cell–Mediated Tumor Rejection Involves Inhibition of Angiogenesis that Is Dependent on IFNγ Receptor Expression by Nonhematopoietic Cells

2000 • 505 citations

Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature

1997 • 485 citations

Evidence for the involvement of endotheliai cell integrin αVβ3 in the disruption of the tumor vascuiature induced by TNF and IFN-γ

1998 • 461 citations

Autocrine Production of IL-10 Mediates Defective IL-12 Production and NF-κB Activation in Tumor-Associated Macrophages

2000 • 421 citations

CD4⁺T cells eliminate MHC class II-negative cancer cellsin vivoby indirect effects of IFN-γ

1999 • 378 citations

Interferon-γ elicits arteriosclerosis in the absence of leukocytes

2000 • 375 citations

Induction of neovascularization in vivo and endothelial proliferation in vitro by tumor-associated macrophages.

1984 • 366 citations

Regulation of the Macrophage Content of Neoplasms by Chemoattractants

1983 • 352 citations

Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer.

1991 • 279 citations

Mig, the Monokine Induced By Interferon-γ, Promotes Tumor Necrosis In Vivo

1997 • 251 citations

Generation and decay of the immune response to a progressive fibrosarcoma. I. Ly-1+2- suppressor T cells down-regulate the generation of Ly-1-2+ effector T cells.

1984 • 249 citations

Interferon-inducible protein-10 identified as a mediator of tumor necrosisin vivo

1996 • 223 citations

Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon gamma.

1993 • 221 citations

Interleukin-10 prevents dendritic cell accumulation and vaccination with granulocyte-macrophage colony-stimulating factor gene-modified tumor cells.

1997 • 200 citations

Stroma is critical for preventing or permitting immunological destruction of antigenic cancer cells.

1992 • 169 citations

Distribution of interferon‐γ receptor in human tissues

1992 • 168 citations

The Murine Antitumor Immune Response and Its Therapeutic Manipulation

1984 • 164 citations

Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration.

1993 • 140 citations

Cyclophosphamide (Cy)-facilitated adoptive immunotherapy of a Cy-resistant tumour. Evidence that Cy permits the expression of adoptive T-cell mediated immunity by removing suppressor T cells rather than by reducing tumour burden.

1988 • 119 citations

Constitutive IL-10 Production Accounts for the High NK Sensitivity, Low MHC Class I Expression, and Poor Transporter Associated with Antigen Processing (TAP)-1/2 Function in the Prototype NK Target YAC-1

1998 • 113 citations

Cooperation between cyclophosphamide tumoricidal activity and host antitumor immunity in the cure of mice bearing large MOPC-315 tumors.

1981 • 100 citations

Immunopotentiation with low-dose cyclophosphamide in the active specific immunotherapy of cancer

1998 • 94 citations

Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10.

1997 • 92 citations

Importance of timing in cyclophosphamide therapy of MOPC-315 tumor-bearing mice.

1980 • 92 citations

Effects of anticancer drugs on the immune system in humans.

1989 • 86 citations

Immune Response Against Large Tumors Eradicated by Treatment with Cyclophosphamide and IL-12

1998 • 68 citations

Some advantages of curing mice bearing a large subcutaneous MOPC-315 tumor with a low dose rather than a high dose of cyclophosphamide.

1983 • 58 citations

INDUCIBLE EXPRESSION OF AN ENDOTHELIAL CELL ANTIGEN ON MURINE MYOCARDIAL VASCULATURE IN ASSOCIATION WITH INTERSTITIAL CELLULAR INFILTRATION

1989 • 44 citations

Interleukin-7/B7.1-encoding adenoviruses induce rejection of transplanted but not nontransplanted tumors.

2000 • 34 citations

Genetic approaches to cancer immunotherapy

1996 • 32 citations

CD4-POSITIVE AND B LYMPHOCYTES IN TRANSPLANTATION IMMUNITY

1993 • 22 citations

Deleted Work

1955 • 0 citations