Divergent effects of estrogen and nicotine on Rho-kinase expression in human coronary vascular smooth muscle cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Estrogen replacement therapy and coronary heart disease: A quantitative assessment of the epidemiologic evidence

1991 • 1,603 citations

Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults.

1993 • 1,542 citations

Signal transduction by G‐proteins, Rho‐kinase and protein phosphatase to smooth muscle and non‐muscle myosin II

2000 • 1,219 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

Passive Smoking and Impaired Endothelium-Dependent Arterial Dilatation in Healthy Young Adults

1996 • 907 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice

1996 • 757 citations

A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

1995 • 711 citations

Impairment of Endothelium-Dependent Pulmonary-Artery Relaxation in Chronic Obstructive Lung Disease

1991 • 538 citations

Endothelial function in health and disease: new insights into the genesis of cardiovascular disease

1998 • 407 citations

The Small GTPase Rho: Cellular Functions and Signal Transduction

1996 • 404 citations

Endothelin, a novel endothelium-derived peptide

1989 • 365 citations

Comparison of the prediction by 27 different factors of coronary heart disease and death in men and women of the Scottish heart health study: cohort study

1997 • 313 citations

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm

1999 • 312 citations

Smoking and cardiovascular disease

1992 • 292 citations

Inhibition of Myosin Phosphatase by Upregulated Rho-Kinase Plays a Key Role for Coronary Artery Spasm in a Porcine Model With Interleukin-1β

2000 • 273 citations

Rho-kinase as a Novel Therapeutic Target in Treatment of Cardiovascular Diseases

2002 • 264 citations

Estrogen Reduces Myointimal Proliferation After Balloon Injury of Rat Carotid Artery

1996 • 260 citations

Diminished vascular response to inhibition of endothelium-derived nitric oxide and enhanced vasoconstriction to exogenously administered endothelin-1 in clinically healthy smokers.

1994 • 237 citations

Canine vascular tissues are targets for androgens, estrogens, progestins, and glucocorticoids.

1982 • 237 citations

Downregulation of Angiotensin II Type 1 Receptor Gene Transcription by Nitric Oxide

1998 • 208 citations

Estrogen Receptors α and β

2000 • 204 citations

Cytoskeletal Rearrangements and Transcriptional Activation of c-fos Serum Response Element by Rho-kinase

1997 • 176 citations

Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells

2004 • 157 citations

Female Sex Hormones and Cardiovascular Disease in Women¹

1997 • 150 citations

Elevated endothelin-1 levels after cigarette smoking

1994 • 148 citations

Mechanism of cigarette smoke condensate induced adhesion of human monocytes to cultured endothelial cells

1994 • 147 citations

Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo

2001 • 106 citations

Estradiol attenuates directed migration of vascular smooth muscle cells in vitro.

1996 • 106 citations

Adenovirus-Mediated Transfer of Dominant-Negative Rho-Kinase Induces a Regression of Coronary Arteriosclerosis in Pigs In Vivo

2001 • 92 citations

Gender-related distinctions in protein kinase C activity in rat vascular smooth muscle

2001 • 91 citations

Involvement of Rho-Kinase in Agonists-Induced Contractions of Arteriosclerotic Human Arteries

2002 • 83 citations

Redistribution of protein kinase C isoforms in association with vascular hypertrophy of rat aorta

1994 • 75 citations

Female Sex Hormones and Cardiovascular Disease in Women

1997 • 66 citations

Clinical implications of endothelial dysfunction

1998 • 54 citations

Enhanced vascular reactivity to protein kinase C activators in genetically hypertensive rats.

1987 • 43 citations

Cigarette smoke extract induces endothelin-1 via protein kinase C in pulmonary artery endothelial cells

2001 • 39 citations

Selected Contribution: Estrogen receptor-α gene transfer inhibits proliferation and NF-κB activation in VSM cells from female rats

2001 • 22 citations