Inhibition of Myosin Phosphatase by Upregulated Rho-Kinase Plays a Key Role for Coronary Artery Spasm in a Porcine Model With Interleukin-1β

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes

1992 • 2,655 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Signal transduction and regulation in smooth muscle

1994 • 1,915 citations

Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity

1989 • 1,032 citations

“Variant” angina: One aspect of a continuous spectrum of vasospastic myocardial ischemia

1978 • 935 citations

Rho-associated Kinase Directly Induces Smooth Muscle Contraction through Myosin Light Chain Phosphorylation

1997 • 576 citations

Coronary-Artery Spasm

1978 • 508 citations

Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.

1992 • 458 citations

The control of protein phosphatase‐1 by targetting subunits

1992 • 376 citations

Coronary Artery Spasm Induced in Atherosclerotic Miniature Swine

1983 • 372 citations

Regulation of Smooth Muscle Contractile Elements by Second Messengers

1989 • 357 citations

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm

1999 • 312 citations

Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin.

1987 • 303 citations

A Novel Protein Phosphatase-1 Inhibitory Protein Potentiated by Protein Kinase C. Isolation from Porcine Aorta Media and Characterization1

1995 • 302 citations

Increased Adventitial Mast Cells in a Patient with Coronary Spasm

1985 • 298 citations

Chronic treatment with interleukin-1 beta induces coronary intimal lesions and vasospastic responses in pigs in vivo. The role of platelet-derived growth factor.

1996 • 283 citations

Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle.

1996 • 280 citations

Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase.

1994 • 261 citations

Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle to calcium.

1992 • 232 citations

Significance of adventitial inflammation of the coronary artery in patients with unstable angina: results at autopsy.

1985 • 226 citations

Phosphorylation of the 20,000-dalton light chain of smooth muscle myosin by the calcium-activated, phospholipid-dependent protein kinase. Phosphorylation sites and effects of phosphorylation.

1987 • 224 citations

Involvement of rho in GTPγS‐induced enhancement of phosphorylation of 20 kDa myosin light chain in vascular smooth muscle cells: inhibition of phosphatase activity

1995 • 187 citations

Possible involvement of the novel CPI‐17 protein in protein kinase C signal transduction of rabbit arterial smooth muscle

1998 • 172 citations

Alterations in cytoplasmic calcium sensitivity during porcine coronary artery contractions as detected by aequorin.

1987 • 171 citations

Enhanced Myosin Light Chain Phosphorylations as a Central Mechanism for Coronary Artery Spasm in a Swine Model With Interleukin-1β

1997 • 153 citations

Coronary artery spasm induced in miniature swine: Angiographic evidence and relation to coronary atherosclerosis

1985 • 96 citations

Spasm of the Coronary Arteries: Causes and Consequences (the Scientist's Viewpoint)

1985 • 79 citations

Coronary Artery Spasm Does Not Depend on the Intracellular Calcium Store but Is Substantially Mediated by the Protein Kinase C–Mediated Pathway in a Swine Model With Interleukin-1β In Vivo

1996 • 50 citations

Role of protein kinase C-mediated pathway in the pathogenesis of coronary artery spasm in a swine model.

1994 • 50 citations

Biochemical Basis for Contraction of Vascular Smooth Muscle

1980 • 46 citations

Effects of calyculin A on tension and myosin phosphorylation in skinned smooth muscle of the rabbit mesenteric artery

1993 • 45 citations

Vasculoprotective Role of Inducible Nitric Oxide Synthase at Inflammatory Coronary Lesions Induced by Chronic Treatment With Interleukin-1β in Pigs in Vivo

1997 • 43 citations

Tyrosine kinase inhibitor suppresses coronary arteriosclerotic changes and vasospastic responses induced by chronic treatment with interleukin-1 beta in pigs in vivo.

1995 • 42 citations

Expression of rho A and rho Kinase mRNAs in Porcine Vascular Smooth Muscle

1996 • 26 citations

Myosin light chain diphosphorylation is enhanced by growth promotion of cultured smooth muscle cells

1996 • 20 citations