Expression of the α7 Isoform of Hepatocyte Nuclear Factor (HNF) 4 Is Activated by HNF6/OC-2 and HNF1 and Repressed by HNF4α1 in the Liver

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

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Control of Pancreas and Liver Gene Expression by HNF Transcription Factors

2004 • 1,293 citations

Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis

2001 • 1,066 citations

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.

1990 • 1,044 citations

Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)

1996 • 941 citations

Negative effect of the transcriptional activator GAL4

1988 • 672 citations

Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms.

1995 • 648 citations

Cdx1 and Cdx2 expression during intestinal development

2000 • 586 citations

Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis

2003 • 563 citations

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos.

1994 • 550 citations

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.

1988 • 523 citations

Liver‐enriched transcription factors and hepatocyte differentiation

1996 • 508 citations

Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

2000 • 489 citations

Mammalian hepatocyte differentiation requires the transcription factor HNF-4α

2000 • 440 citations

Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst.

1994 • 372 citations

Distinct classes of transcriptional activating domains function by different mechanisms

1990 • 368 citations

The onecut transcription factor HNF6 is required for normal development of the biliary tract

2002 • 359 citations

Transcription Factor Hepatocyte Nuclear Factor 6 Regulates Pancreatic Endocrine Cell Differentiation and Controls Expression of the Proendocrine Gene ngn3

2000 • 322 citations

Transcriptional regulation of granulocyte and monocyte development

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A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells.

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The Orphan Nuclear Receptor SHP Inhibits Hepatocyte Nuclear Factor 4 and Retinoid X Receptor Transactivation: Two Mechanisms for Repression

2000 • 303 citations

Shaping animal body plans in development and evolution by modulation of Hox expression patterns

1998 • 295 citations

Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4−/− embryos

1997 • 295 citations

Variant Hepatocyte Nuclear Factor 1 is required for visceral endoderm specification

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HNF4: A central regulator of hepatocyte differentiation and function

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vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1.

1991 • 276 citations

Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences

2001 • 271 citations

A transcription factor regulatory circuit in differentiated pancreatic cells

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Hepatocyte Nuclear Factor-1α, GATA-4, and Caudal Related Homeodomain Protein Cdx2 Interact Functionally to Modulate Intestinal Gene Transcription

2002 • 232 citations

A QUANTITATIVE COMPARISON OF FORMATION OF SPONTANEOUS AND VIRUS-PRODUCED VIABLE HYBRIDS

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2002 • 221 citations

Expression of the vHNF1/HNF1β homeoprotein gene during mouse organogenesis

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A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young

2001 • 215 citations

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1976 • 201 citations

The Cut-Homeodomain Transcriptional Activator HNF-6 Is Coexpressed with Its Target Gene HNF-3β in the Developing Murine Liver and Pancreas

1997 • 170 citations

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Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes

1997 • 165 citations

Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis

1994 • 163 citations

Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles

1992 • 150 citations

HNF-6 Is Expressed in Endoderm Derivatives and Nervous System of the Mouse Embryo and Participates to the Cross-Regulatory Network of Liver-Enriched Transcription Factors

1997 • 149 citations

Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levels.

2000 • 149 citations

Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas

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Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain.

1996 • 145 citations

Functional Domains of the Nuclear Receptor Hepatocyte Nuclear Factor 4

1997 • 144 citations

Hepatocyte Nuclear Factor 4 Provokes Expression of Epithelial Marker Genes, Acting As a Morphogen in Dedifferentiated Hepatoma Cells

1998 • 142 citations

Regulatory Mechanisms Controlling Human Hepatocyte Nuclear Factor 4α Gene Expression

2001 • 136 citations

A distal dimerization domain is essential for DNA-binding by the atypical HNF1 homeodomain

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Modulation of Hepatic Gene Expression by Hepatocyte Nuclear Factor 1

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Nuclear receptors and genetic disease

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An alternative splice variant of the tissue specific transcription factor HNF4 predominates in undifferentiated murine cell types

1998 • 113 citations

Interaction between the homeodomain proteins Cdx2 and HNF1α mediates expression of the lactase-phlorizin hydrolase gene

2000 • 112 citations

Hepatocyte Nuclear Factor 4 Expression Overcomes Repression of the Hepatic Phenotype in Dedifferentiated Hepatoma Cells

1997 • 111 citations

Isoforms of Hepatocyte Nuclear Factor-6 Differ in DNA-binding Properties, Contain a Bifunctional Homeodomain, and Define the New ONECUT Class of Homeodomain Proteins

1998 • 107 citations

Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function

2002 • 106 citations

OC-2, a Novel Mammalian Member of the ONECUT Class of Homeodomain Transcription Factors Whose Function in Liver Partially Overlaps with That of Hepatocyte Nuclear Factor-6

1999 • 106 citations

Defective Ureagenesis in Mice Carrying a Liver-specific Disruption of Hepatocyte Nuclear Factor 4α (HNF4α)

2002 • 103 citations

Mutation in the HNF-4alpha gene affects insulin secretion and triglyceride metabolism.

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vHNF1 is expressed in epithelial cells of distinct embryonic origin during development and precedes HNF1 expression

1991 • 99 citations

Tissue-Specific Regulation of Mouse Hepatocyte Nuclear Factor 4 Expression

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Expression of HNF4α isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3′ end splicing

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A Mouse Hepatoma Cell Line which Secretes Several Serum Proteins Including Albumin and α-foetoprotein

1975 • 92 citations

The DNA Binding Domain of Hepatocyte Nuclear Factor 4 Mediates Cooperative, Specific Binding to DNA and Heterodimerization with the Retinoid X Receptor α

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Hepatocyte Nuclear Factor 4α Isoforms Originated from the P1 Promoter Are Expressed in Human Pancreatic β-Cells and Exhibit Stronger Transcriptional Potentials than P2 Promoter-Driven Isoforms

2003 • 82 citations

Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function

2002 • 81 citations

Physical and Functional Interaction of Acyl-CoA-binding Protein with Hepatocyte Nuclear Factor-4α

2003 • 77 citations

Hepatocyte Nuclear Factor 1α Gene Inactivation Impairs Chromatin Remodeling and Demethylation of the Phenylalanine Hydroxylase Gene

1997 • 75 citations

An enhancer element 6 kb upstream of the mouse HNF4alpha1 promoter is activated by glucocorticoids and liver-enriched transcription factors

2001 • 66 citations

Developmentally Regulated N-terminal Variants of the Nuclear Receptor Hepatocyte Nuclear Factor 4α Mediate Multiple Interactions through Coactivator and Corepressor-Histone Deacetylase Complexes

2002 • 64 citations

Hepatocyte Nuclear Factor 4 enhances the Hepatocyte Nuclear Factor 1 -mediated activation of transcription

2004 • 64 citations

Mechanism of a Transcriptional Cross Talk between Transforming Growth Factor-β–regulated Smad3 and Smad4 Proteins and Orphan Nuclear Receptor Hepatocyte Nuclear Factor-4

2003 • 51 citations

Repression of Hepatocyte Nuclear Factor 4α by Tumor Suppressor p53: Involvement of the Ligand-Binding Domain and Histone Deacetylase Activity

2002 • 49 citations

Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2

2003 • 49 citations

OC-3, a Novel Mammalian Member of the ONECUT Class of Transcription Factors

2002 • 48 citations

A novel isoform of rat hepatocyte nuclear factor 4 (HNF-4)

1992 • 45 citations

Generation of a conditionally null allele of hnf4α

2002 • 44 citations

The Activity of the Highly Inducible Mouse Phenylalanine Hydroxylase Gene Promoter Is Dependent upon a Tissue-Specific, Hormone-Inducible Enhancer

1996 • 41 citations

Molecular Aspects of Vertebrate Retinal Development

2002 • 39 citations

Phenotypic effects of the forced expression of HNF4 and HNF1α are conditioned by properties of the recipient cell

1998 • 30 citations

An exogenous albumin promoter can become silent in dedifferentiated hepatoma variants as well as intertypic hybrids.

1990 • 22 citations

Retinoic acid receptor alpha1 variants, RARalpha1DeltaB and RARalpha1DeltaBC, define a new class of nuclear receptor isoforms

2001 • 20 citations