The Cut-Homeodomain Transcriptional Activator HNF-6 Is Coexpressed with Its Target Gene HNF-3β in the Developing Murine Liver and Pancreas

Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

1996 • 1,607 citations

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1996 • 1,505 citations

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

1993 • 1,269 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

Developmental biology of the pancreas

1995 • 942 citations

Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)

1996 • 941 citations

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

1994 • 786 citations

Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo

1993 • 680 citations

Five years on the wings of fork head

1996 • 657 citations

The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins

1993 • 619 citations

Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus

1982 • 611 citations

Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control.

1996 • 582 citations

Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny

1995 • 562 citations

The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

1996 • 548 citations

Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes.

1989 • 545 citations

The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis.

1994 • 518 citations

Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.

1991 • 517 citations

Liver‐enriched transcription factors and hepatocyte differentiation

1996 • 508 citations

Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 α, β and γ genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm

1993 • 505 citations

A transcriptional hierarchy involved in mammalian cell-type specification

1992 • 428 citations

Development and applications of a molecular genetic linkage map of the mouse genome

1991 • 427 citations

Isolation of ORC6 , a Component of the Yeast Origin Recognition Complex by a One-Hybrid System

1993 • 416 citations

Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast

1993 • 416 citations

DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally

1990 • 410 citations

Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst.

1994 • 372 citations

Hepatocyte Nuclear Factor 3/fork head Homolog 11 Is Expressed in Proliferating Epithelial and Mesenchymal Cells of Embryonic and Adult Tissues

1997 • 359 citations

The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix.

1994 • 357 citations

An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array

1993 • 336 citations

Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice

1993 • 325 citations

Localization of specific mRNAs in Xenopus embryos by whole-mount in situ hybridization

1990 • 323 citations

Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung.

1996 • 294 citations

HNF-3β as a regulator of floor plate development

1994 • 287 citations

Linkage, recombination and mapping

1981 • 279 citations

Hepatocyte Nuclear Factor 3β is Involved in Pancreatic β-Cell-Specific Transcription of the pdx-1 Gene

1997 • 256 citations

The α₁-Fetoprotein Locus Is Activated by a Nuclear Receptor of the Drosophila FTZ-F1 Family

1996 • 242 citations

Expression of hepatic transcription factors during liver development and oval cell differentiation.

1994 • 230 citations

Onset of cell-specific gene expression in the developing mouse pancreas.

1992 • 224 citations

Development and applications of a molecular genetic linkage map of the mouse genome

1991 • 208 citations

The HNF-3 Gene Family of Transcription Factors in Mice: Gene Structure, cDNA Sequence, and mRNA Distribution

1994 • 204 citations

Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations

1971 • 192 citations

Hepatocyte nuclear factor 3 beta contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head protein.

1992 • 188 citations

Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain.

1996 • 145 citations

The Transcriptional Activator Hepatocyte Nuclear Factor 6 Regulates Liver Gene Expression

1996 • 144 citations

In vivo cell transformation: Neogenesis of beta cells from pancreatic ductal cells,

1995 • 143 citations

Hepatocyte Nuclear Factor 3 Activates Transcription of Thyroid Transcription Factor 1 in Respiratory Epithelial Cells

1996 • 139 citations

The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families.

1993 • 126 citations

Molecular Genetics of Early Liver Development

1996 • 105 citations

The Restricted Promoter Activity of the Liver Transcription Factor Hepatocyte Nuclear Factor 3β Involves a Cell-Specific Factor and Positive Autoactivation

1992 • 98 citations

The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo

1997 • 97 citations

Decreased Expression of Hepatocyte Nuclear Factor 3α during the Acute-Phase Response Influences Transthyretin Gene Transcription

1995 • 95 citations

Tissue-Specific Regulation of Mouse Hepatocyte Nuclear Factor 4 Expression

1994 • 95 citations

Transthyretin immunoreactivity in human and porcine liver, choroid plexus, and pancreatic islets.

1989 • 81 citations

Fetal and adult localization of C/EBP: evidence for combinatorial action of transcription factors in cell-specific gene expression

1990 • 79 citations

Hepatocyte nuclear factor-3 alpha promoter regulation involves recognition by cell-specific factors, thyroid transcription factor-1, and autoactivation.

1997 • 62 citations

Binding Sites for Hepatocyte Nuclear Factor 3β or 3γ and Pancreas Transcription Factor 1 Are Required for Efficient Expression of the Gene Encoding Pancreatic α-Amylase

1995 • 58 citations

Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression.

1994 • 57 citations

A molecular genetic linkage map of mouse chromosome 9 with regional localizations for the Gsta, T3g, Ets-1 and Ldlr loci.

1989 • 53 citations

The restricted promoter activity of the liver transcription factor hepatocyte nuclear factor 3 beta involves a cell-specific factor and positive autoactivation.

1992 • 51 citations

Identification and Chromosomal Localization of Atm, the Mouse Homolog of the Ataxia–Telangiectasia Gene

1996 • 49 citations

Insulin gene: organisation, expression and regulation.

1996 • 45 citations

The Orphan Nuclear Receptor RORα (RORA) Maps to a Conserved Region of Homology on Human Chromosome 15q21-q22 and Mouse Chromosome 9

1995 • 37 citations

Cytokine regulation of the liver transcription factor hepatocyte nuclear factor-3 beta is mediated by the C/EBP family and interferon regulatory factor 1.

1995 • 35 citations

In VivoFootprinting with Limiting Amounts of Embryo Tissues: A Role for C/EBPβ in Early Hepatic Development

1997 • 26 citations

The Chromosomal Mapping of Four Genes Encoding Winged Helix Proteins Expressed Early in Mouse Development

1996 • 11 citations