Regulatory Mechanisms Controlling Human Hepatocyte Nuclear Factor 4α Gene Expression

Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

1996 • 1,607 citations

Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

2000 • 1,426 citations

LXR, a nuclear receptor that defines a distinct retinoid response pathway.

1995 • 1,089 citations

Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis

2001 • 1,066 citations

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.

1990 • 1,044 citations

Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)

1996 • 941 citations

GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo

1998 • 673 citations

Analysis of Chromatin Structure byin VivoFormaldehyde Cross-Linking

1997 • 610 citations

Hepatocyte Nuclear Factor 1 Inactivation Results in Hepatic Dysfunction, Phenylketonuria, and Renal Fanconi Syndrome

1996 • 574 citations

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos.

1994 • 550 citations

Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

2000 • 489 citations

HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally.

1990 • 466 citations

Mammalian hepatocyte differentiation requires the transcription factor HNF-4α

2000 • 440 citations

A transcriptional hierarchy involved in mammalian cell-type specification

1992 • 428 citations

Regulation of the Apolipoprotein AI Gene by ARP-1, a Novel Member of the Steroid Receptor Superfamily

1991 • 382 citations

Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst.

1994 • 372 citations

Regulation of a Transcription Factor Network Required for Differentiation and Metabolism

1998 • 343 citations

Variant Hepatocyte Nuclear Factor 1 is required for visceral endoderm specification

1999 • 282 citations

Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly.

1987 • 281 citations

Acetylation Regulates Transcription Factor Activity at Multiple Levels

2000 • 268 citations

Distinct Functions Are Implicated for the GATA-4, -5, and -6 Transcription Factors in the Regulation of Intestine Epithelial Cell Differentiation

1998 • 236 citations

Human Hepatocyte Nuclear Factor 4 Isoforms Are Encoded by Distinct and Differentially Expressed Genes

1996 • 236 citations

Essential role for the homeoprotein vHNF1/HNF1β in visceral endoderm differentiation

1999 • 231 citations

Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4.

1991 • 192 citations

Protein Kinase A-Dependent Phosphorylation Modulates DNA-Binding Activity of Hepatocyte Nuclear Factor 4

1997 • 179 citations

LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia.

1991 • 171 citations

Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis

1994 • 163 citations

Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles

1992 • 150 citations

HNF-6 Is Expressed in Endoderm Derivatives and Nervous System of the Mouse Embryo and Participates to the Cross-Regulatory Network of Liver-Enriched Transcription Factors

1997 • 149 citations

Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain.

1996 • 145 citations

Hepatocyte Nuclear Factor 4 Provokes Expression of Epithelial Marker Genes, Acting As a Morphogen in Dedifferentiated Hepatoma Cells

1998 • 142 citations

Modulation of Transcriptional Activation and Coactivator Interaction by a Splicing Variation in the F Domain of Nuclear Receptor Hepatocyte Nuclear Factor 4α1

1999 • 130 citations

Immunodetection of multiple species of retinoic acid receptor α: Evidence for phosphorylation

1992 • 129 citations

Modulation of Hepatic Gene Expression by Hepatocyte Nuclear Factor 1

1997 • 126 citations

Hepatocyte Nuclear Factor 4 Expression Overcomes Repression of the Hepatic Phenotype in Dedifferentiated Hepatoma Cells

1997 • 111 citations

Transcriptional regulation of liver development

2000 • 103 citations

Functional Association between CBP and HNF4 inTrans-activation

1997 • 103 citations

Tissue-Specific Regulation of Mouse Hepatocyte Nuclear Factor 4 Expression

1994 • 95 citations

The Mouse Fetoprotein Transcription Factor (FTF) Gene Promoter Is Regulated by Three GATA Elements with Tandem E Box and Nkx Motifs, and FTF in Turn Activates the Hnf3β, Hnf4α, and Hnf1α Gene Promoters

2001 • 89 citations

CREB-binding Protein Is a Transcriptional Coactivator for Hepatocyte Nuclear Factor-4 and Enhances Apolipoprotein Gene Expression

1999 • 88 citations

Recruitment of hepatocyte nuclear factor 4 into specific intranuclear compartments depends on tyrosine phosphorylation that affects its DNA-binding and transactivation potential.

1995 • 88 citations

Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver

1994 • 82 citations

Human Acidic Ribosomal Phosphoproteins PO, P1, and P2: Analysis of cDNA Clones, In Vitro Synthesis, and Assembly

1987 • 68 citations

Characterization of ligand-dependent phosphorylation of the estrogen receptor.

1994 • 65 citations

Chicken Ovalbumin Upstream Promoter Transcription Factors Act as Auxiliary Cofactors for Hepatocyte Nuclear Factor 4 and Enhance Hepatic Gene Expression

1997 • 65 citations

Serine/Threonine Phosphorylation of Orphan Receptor Hepatocyte Nuclear Factor 4

1997 • 63 citations

Activation of the Prolactin Gene by Peroxisome Proliferator-activated Receptor-α Appears to Be DNA Binding-independent

1998 • 54 citations

An indirect negative autoregulatory mechanism involved in hepatocyte nuclear factor-1 gene expression

1993 • 52 citations

Lysine 246 of the Vitamin D Receptor Is Crucial for Ligand-dependent Interaction with Coactivators and Transcriptional Activity

1999 • 45 citations

COUP-TF II homodimers are formed in preference to heterodimers with RXRα or TRβ in intact cells

1995 • 45 citations

Isolation and characterization of a third isoform of human hepatocyte nuclear factor 4

1996 • 45 citations

Transcriptional hierarchy in Xenopus embryogenesis: HNF4 a maternal factor involved in the developmental activation of the gene encoding the tissue specific transcription factor HNF1α (LFB1)

1996 • 41 citations

Retinoic Acid Mediates Down-regulation of the α-Fetoprotein Gene through Decreased Expression of Hepatocyte Nuclear Factors

1998 • 40 citations

Analysis of the HNF4α gene in Caucasian Type II diabetic nephropathic patients

2000 • 38 citations

Phenotypic effects of the forced expression of HNF4 and HNF1α are conditioned by properties of the recipient cell

1998 • 30 citations

Identification of Retinoic Acid-Responsive Elements on the HNF1α and HNF4α Genes

2000 • 25 citations

Hepatocyte nuclear factor-4 prevents silencing of hepatocyte nuclear factor-1 expression in hepatoma x fibroblast cell hybrids

1997 • 24 citations