Combination Therapy with Anti–CTL Antigen-4 and Anti-4-1BB Antibodies Enhances Cancer Immunity and Reduces Autoimmunity

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

2003 • 1,564 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Tumor Antigens Recognized by T Lymphocytes

1994 • 1,238 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

1999 • 1,000 citations

Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells

2003 • 919 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

gp100/pmel 17 Is a Murine Tumor Rejection Antigen: Induction of “Self”-reactive, Tumoricidal T Cells Using High-affinity, Altered Peptide Ligand

1998 • 490 citations

Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy.

1985 • 486 citations

Tumor-specific killer cells in paraneoplastic cerebellar degeneration

1998 • 449 citations

Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.

2000 • 421 citations

CTLA-4: a negative regulator of autoimmune disease.

1996 • 382 citations

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

1995 • 323 citations

Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine

2001 • 307 citations

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

2002 • 265 citations

Coupling and Uncoupling of Tumor Immunity and Autoimmunity

1999 • 245 citations

Regulatory T cells in autoimmunity

2007 • 228 citations

Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy

1999 • 223 citations

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

2002 • 215 citations

Induction of anti-self-immunity to cure cancer

1995 • 207 citations

Implicating a role for immune recognition of self in tumor rejection: passive immunization against the brown locus protein.

1995 • 186 citations

Dendritic Cells Infiltrating Tumors Cotransduced with Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf) and Cd40 Ligand Genes Take up and Present Endogenous Tumor-Associated Antigens, and Prime Naive Mice for a Cytotoxic T Lymphocyte Response

1999 • 184 citations

Anti–4-1bb Monoclonal Antibodies Abrogate T Cell–Dependent Humoral Immune Responses in Vivo through the Induction of Helper T Cell Anergy

1999 • 184 citations

Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

1997 • 182 citations

Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease

2002 • 178 citations

CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice

2003 • 174 citations

Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB

2002 • 162 citations

The 4-1BB Costimulation Augments the Proliferation of CD4+CD25+ Regulatory T Cells

2004 • 157 citations

CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice

2003 • 152 citations

Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells.

2002 • 124 citations

Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti–CTLA-4 antibodies

2005 • 109 citations

Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells

2000 • 102 citations

Immunity to melanoma: unraveling the relation of tumor immunity and autoimmunity

2003 • 99 citations

The risk of autoimmunity associated with tumor immunotherapy

2001 • 87 citations

Evaluation of a complementarity-determining region-grafted (humanized) anti-carcinoembryonic antigen monoclonal antibody in preclinical and clinical studies.

1995 • 84 citations

Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice

2002 • 79 citations

Selective functional deficit in dendritic cell – T cell interaction is a crucial mechanism in chronic hepatitis B virus infection

2004 • 76 citations

Redundant and Alternative Roles for Activating Fc Receptors and Complement in an Antibody-Dependent Model of Autoimmune Vitiligo

2002 • 73 citations

Identification of tumour rejection antigens recognized by T lymphocytes.

1992 • 72 citations

Enhancement of the anti-tumor immune response using a combination of interferon-γ and B7 expression in an experimental mammary carcinoma

1998 • 47 citations

Anti–human CTLA-4 monoclonal antibody promotes T-cell expansion and immunity in a hu-PBL-SCID model: a new method for preclinical screening of costimulatory monoclonal antibodies

2004 • 31 citations

Cytotoxic T Lymphocyte Antigen 4 (CD152) Regulates Self-Reactive T cells in BALB/c but not in the Autoimmune NOD Mouse

2000 • 17 citations

Alternative roles for interferon-gamma in the immune response to DNA vaccines encoding related melanosomal antigens.

2001 • 14 citations

Antitumor effects of recombinant interleukin-6 expressed in eukaryotic cells

1993 • 13 citations