Activation of αVβ3 on Vascular Cells Controls Recognition of Prothrombin

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

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RGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS

1996 • 3,074 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Initiation of Platelet Adhesion by Arrest onto Fibrinogen or Translocation on von Willebrand Factor

1996 • 1,178 citations

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

1989 • 1,126 citations

Platelet Membrane Glycoprotein IIb/IIIa: Member of a Family of Arg-Gly-Asp—Specific Adhesion Receptors

1986 • 945 citations

Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function

1995 • 900 citations

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

1990 • 871 citations

THE ROLE OF ENDOTHELIAL CELLS IN INFLAMMATION

1990 • 808 citations

Apoptotic Vascular Endothelial Cells Become Procoagulant

1997 • 612 citations

Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor.

1987 • 571 citations

Limited Proteolysis of Protein Kinase C Subspecies by Calcium-dependent Neutral Protease (Calpain)

1989 • 470 citations

A player of many parts: The spotlight falls on thrombin's structure

1993 • 444 citations

The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.

1997 • 411 citations

Vitronectin and its receptors

1993 • 406 citations

Regulation of Cell Migration by the Calcium-dependent Protease Calpain

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Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen.

1988 • 374 citations

Activation of protein kinase C precedes alpha 5 beta 1 integrin-mediated cell spreading on fibronectin.

1993 • 358 citations

Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway

1993 • 353 citations

Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.

1996 • 343 citations

Regulation of Integrin α5β1-Fibronectin Interactions by Divalent Cations

1995 • 325 citations

Role of fibrinogen alpha and gamma chain sites in platelet aggregation.

1992 • 315 citations

The regulation of vascular function by P2 receptors: multiple sites and multiple receptors

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Effects of fluid dynamic forces on vascular cell adhesion.

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Regulation of endothelial cell coagulant properties

1989 • 255 citations

Evidence that three adhesive proteins interact with a common recognition site on activated platelets.

1984 • 254 citations

Synthesis of a new cell penetrating calpain inhibitor (calpeptin)

1988 • 254 citations

Aggregation of complement receptors on human neutrophils in the absence of ligand.

1987 • 250 citations

Induction of the fibrinogen receptor on human platelets by intracellular mediators.

1987 • 240 citations

Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin.

1993 • 240 citations

Complementary Roles for Receptor Clustering and Conformational Change in the Adhesive and Signaling Functions of Integrin αIIbβ3

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Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin.

1990 • 238 citations

VIBRIO PARAHÆMOLYTICUS

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Inhibition of fibrinogen binding to GP IIb-IIIa by a GP IIIa peptide

1991 • 221 citations

Perspectives series: cell adhesion in vascular biology. Integrin signaling in vascular biology.

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An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function.

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A mechanism for divalent cation regulation of beta 3-integrins.

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Integrin (alpha v beta 3)-ligand interaction. Identification of a heterodimeric RGD binding site on the vitronectin receptor.

1990 • 193 citations

Calpain Cleavage of the Cytoplasmic Domain of the Integrin β2 Subunit

1995 • 173 citations

Fibrinogen Is a Ligand for Integrin α5β1 on Endothelial Cells

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Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain

1996 • 167 citations

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1989 • 164 citations

The isomorphous structures of prethrombin2, hirugen–, and PPACK–thrombin: Changes accompanying activation and exosite binding to thrombin

1994 • 144 citations

Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites.

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The Cell Adhesion Domain in Plasma Vitronectin Is Cryptic

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Human endothelial cells express integrin receptors on the luminal aspect of their membrane

1992 • 131 citations

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1997 • 117 citations

Modulation of Cellular Signals by Calpain

1992 • 117 citations

Stimulation of migration of human aortic smooth muscle cells by vitronectin: implications for atherosclerosis

1994 • 107 citations

Agonist-activated αvμ3 on Platelets and Lymphocytes Binds to the Matrix Protein Osteopontin

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An Arg-Gly-Asp sequence within thrombin promotes endothelial cell adhesion.

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1998 • 100 citations

HAEMOSTATIC FACTORS IN HUMAN AORTIC INTIMA

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Endothelium and Regulation of Coagulation

1991 • 82 citations

The Ligand Recognition Specificity of β3 Integrins

1996 • 80 citations

Activation of the Integrin αvβ3 Involves a Discrete Cation-binding Site That Regulates Conformation

1996 • 77 citations

Cleavage of the α6A Subunit Is Essential for Activation of the α6Aβ1 Integrin by Phorbol 12-Myristate 13-Acetate

1996 • 61 citations

Interaction of Integrin αIIbβ3 with Multiple Fibrinogen Domains during Platelet Adhesion

1995 • 57 citations

The mouse vitronectin receptor is a T cell activation antigen.

1991 • 52 citations

Phorbol 12-myristate 13-acetate-stimulated phosphorylation of erythrocyte membrane skeletal proteins is blocked by calpain inhibitors: possible role of protein kinase M

1993 • 50 citations

Regulation of integrin‐mediated adhesion at focal contacts by cyclic AMP

1993 • 46 citations

Tissue factor regulation in vascular smooth muscle: A summary of studies performed using in vivo and in vitro models

1993 • 45 citations

Identification of an Active Sequence within the First Immunoglobulin Domain of Intercellular Cell Adhesion Molecule-1 (ICAM-1) That Interacts with Fibrinogen

1996 • 40 citations

Differential regulation of chemoattractant-stimulated beta 2, beta 3, and beta 7 integrin activity.

1998 • 37 citations

Differential Regulation of Chemoattractant-Stimulated β2, β3, and β7 Integrin Activity

1998 • 33 citations

Thrombin adhesive properties: induction by plasmin and heparan sulfate.

1993 • 28 citations

Tissue Prothrombin

1997 • 26 citations

Stimulation of platelet glycoprotein IIb‐IIIa (α_IIbβ₃‐integrin) functional activity by a monoclonal antibody to the N‐terminal region of glycoprotein IIIa

1996 • 25 citations

Regulation of αIIbβ3 Function in Human B Lymphocytes

1998 • 21 citations

Catabolism of rabbit prothrombin in rabbits: uptake of prothrombin by the aorta wall before and after a de-endothelializing injury in vivo.

1995 • 16 citations

Procoagulant Properties of Atherosclerotic Aortas^a

1994 • 9 citations

Optimal Reaction Conditions for the Enzymatic Synthesis of Optically Active <scp>d</scp>‐p‐Hydroxyphenylglycine from 5‐substituted Hydantoin Using <scp>d</scp>‐Hydantoinase and N‐Carbamoylase

1995 • 4 citations