Role of Integrin αvβ3 in Vascular Biology

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

RGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS

1996 • 3,074 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Platelet Glycoprotein IIb/IIIa Receptor Blockade and Low-Dose Heparin during Percutaneous Coronary Revascularization

1997 • 1,922 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

1990 • 871 citations

Exposure of platelet fibrinogen receptors by ADP and epinephrine.

1979 • 868 citations

Randomised trial of coronary intervention with antibody against platelet IIb/IIIa iritegrin for reduction of clinical restenosis: results at six months

1994 • 852 citations

The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression

1996 • 739 citations

Regulation of Integrin Function by the Urokinase Receptor

1996 • 734 citations

Human platelets possess an inducible and saturable receptor specific for fibrinogen.

1979 • 713 citations

The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

1996 • 680 citations

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.

1992 • 669 citations

Glanzmann's thrombasthenia: the spectrum of clinical disease

1990 • 623 citations

Disruption of Angiogenesis by PEX, a Noncatalytic Metalloproteinase Fragment with Integrin Binding Activity

1998 • 618 citations

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.

1992 • 605 citations

Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor.

1987 • 571 citations

Ca2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils

1995 • 555 citations

Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins.

1994 • 527 citations

A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin.

1985 • 517 citations

Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex.

1993 • 510 citations

The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro.

1995 • 508 citations

alpha vbeta 3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF

1997 • 493 citations

Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors.

1988 • 481 citations

Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to “integrin”.

1987 • 466 citations

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen.

1994 • 447 citations

A β ₃ Integrin Mutation Abolishes Ligand Binding and Alters Divalent Cation-Dependent Conformation

1990 • 418 citations

Vitronectin and its receptors

1993 • 406 citations

Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms.

1993 • 394 citations

Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in vitro.

1994 • 392 citations

Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts.

1991 • 387 citations

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis.

1996 • 385 citations

Barbourin. A GPIIb-IIIa-specific integrin antagonist from the venom of Sistrurus m. barbouri

1991 • 373 citations

Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells

1989 • 343 citations

Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor–type integrins inhibits retinal neovascularization

1996 • 336 citations

The role of integrins in the maintenance of endothelial monolayer integrity.

1991 • 290 citations

Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets

1991 • 289 citations

Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of the Platelet Integrin Glycoprotein IIb/IIIa Blocker Integrelin in Elective Coronary Intervention

1995 • 282 citations

The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin.

1990 • 282 citations

The Urokinase Receptor Is a Major Vitronectin-Binding Protein on Endothelial Cells

1996 • 252 citations

ArgGlyAsp (RGD) peptides and the anti-vitronectin receptor antibody 23C6 inhibit dentine resorption and cell spreading by osteoclasts*1

1991 • 246 citations

Requirement of Receptor-bound Urokinase-type Plasminogen Activator for Integrin αvβ5-directed Cell Migration

1996 • 244 citations

Ligand occupancy of the alpha-V-beta3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor.

1996 • 243 citations

Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium.

1993 • 242 citations

Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin.

1993 • 240 citations

Complementary Roles for Receptor Clustering and Conformational Change in the Adhesive and Signaling Functions of Integrin αIIbβ3

1998 • 239 citations

The Arg-Gly-Asp binding domain of the vitronectin receptor. Photoaffinity cross-linking implicates amino acid residues 61-203 of the beta subunit.

1988 • 238 citations

Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors.

1994 • 233 citations

cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors.

1986 • 231 citations

Evidence that arginyl-glycyl-aspartate peptides and fibrinogen gamma chain peptides share a common binding site on platelets.

1987 • 222 citations

Ligand and cation binding are dual functions of a discrete segment of the integrin β3 subunit: Cation displacement is involved in ligand binding

1994 • 220 citations

Transendothelial migration of neutrophils involves integrin-associated protein (CD47).

1995 • 217 citations

Thrombospondin modulates alpha v beta 3 function through integrin-associated protein.

1996 • 217 citations

Perspectives series: cell adhesion in vascular biology. Integrin signaling in vascular biology.

1997 • 215 citations

α _v β ₃ Integrin Expression in Normal and Atherosclerotic Artery

1995 • 215 citations

Outside-in Integrin Signal Transduction

1996 • 214 citations

Integrin and Arg-Gly-Asp Dependence of Cell Adhesion to the Native and Unfolded Triple Helix of Collagen Type VI

1993 • 212 citations

Transient functional expression of alphaVbeta 3 on vascular cells during wound repair.

1996 • 203 citations

In vivo behavior of neutrophils from two patients with distinct inherited leukocyte adhesion deficiency syndromes.

1993 • 199 citations

A mechanism for divalent cation regulation of beta 3-integrins.

1994 • 196 citations

Endothelial cell attachment and spreading on human tenascin is mediated by α2β1 and αVβ 3 integrins

1993 • 194 citations

Interaction of Plasminogen Activator Inhibitor (PAI-1) with Vitronectin

1989 • 191 citations

Inhibition of neointimal hyperplasia by blocking αvβ3 integrin with a small peptide antagonist GpenGRGDSPCA*

1994 • 190 citations

Platelet glycoprotein IIb-IIIa-like proteins mediate endothelial cell attachment to adhesive proteins and the extracellular matrix.

1987 • 185 citations

Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor .alpha.-subunits and platelet glycoprotein IIb

1987 • 183 citations

Regulation of Integrin Affinity States through an NP XY Motif in the β Subunit Cytoplasmic Domain

1995 • 181 citations

Modulation of vitronectin receptor binding by membrane lipid composition.

1990 • 180 citations

Platelet vitronectin receptor expression differentiates Iraqi-Jewish from Arab patients with Glanzmann thrombasthenia in Israel

1991 • 173 citations

Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIbbeta 3

1997 • 170 citations

Inhibition of integrin function by a cyclic RGD-containing peptide prevents neointima formation.

1994 • 168 citations

Ligand Binding to Integrin αIIbβ3 Is Dependent on a MIDAS-like Domain in the β3 Subunit

1996 • 168 citations

A 50-kDa integrin-associated protein is required for integrin-regulated calcium entry in endothelial cells.

1993 • 167 citations

Basic FGF and TGF-β differentially modulate integrin expression of human microvascular endothelial cells

1992 • 163 citations

Selective αvβ3 integrin blockade potently limits neointimal hyperplasia and lumen stenosis following deep coronary arterial stent injury1:

1997 • 159 citations

Human microvascular endothelial cells use beta 1 and beta 3 integrin receptor complexes to attach to laminin.

1990 • 155 citations

Vascular Smooth Muscle α _v β ₃ Integrin Mediates Arteriolar Vasodilation in Response to RGD Peptides

1996 • 148 citations

Human endothelial cells express integrin receptors on the luminal aspect of their membrane

1992 • 131 citations

Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites.

1990 • 131 citations

Immunochemical and amino-terminal sequence comparison of two cytoadhesins indicates they contain similar or identical beta subunits and distinct alpha subunits.

1987 • 131 citations

Human and bovine endothelial cells synthesize membrane proteins similar to human platelet glycoproteins IIb and IIIa.

1985 • 131 citations

Plasminogen interacts with human platelets through two distinct mechanisms.

1986 • 129 citations

Site-directed mutagenesis of the arginine-glycine-aspartic acid in vitronectin abolishes cell adhesion

1993 • 125 citations

Chemical cross-linking of arginyl-glycyl-aspartic acid peptides to an adhesion receptor on platelets.

1988 • 119 citations

Ca2+Suppresses Cell Adhesion to Osteopontin by Attenuating Binding Affinity for Integrin αvβ3

1995 • 114 citations

Isolation and Characterization of a Platelet Membrane Protein Related to the Vitronectin Receptor

1989 • 109 citations

Stimulation of migration of human aortic smooth muscle cells by vitronectin: implications for atherosclerosis

1994 • 107 citations

Agonist-activated αvμ3 on Platelets and Lymphocytes Binds to the Matrix Protein Osteopontin

1997 • 106 citations

Granulocyte-macrophage and macrophage colony-stimulating factors differentially regulate alpha v integrin expression on cultured human macrophages.

1993 • 105 citations

Alpha v integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion

1994 • 105 citations

Selective inactivation of the Arg-Gly-Asp-Ser (RGDS) binding site in von Willebrand factor by site-directed mutagenesis.

1992 • 98 citations

Integrin receptor-mediated mobilisation of intranuclear calcium in rat osteoclasts

1993 • 98 citations

Cell adhesion molecules in angiogenesis

1996 • 97 citations

The vitronectin receptor serves as an accessory molecule for the activation of a subset of gamma/delta T cells.

1991 • 93 citations

Requirement of Integrin β3 Tyrosine 747 for β3 Tyrosine Phosphorylation and Regulation of αvβ3 Avidity

1997 • 86 citations

Critical Residues for Ligand Binding in an I Domain-like Structure of the Integrin β1 Subunit

1996 • 85 citations

Distinct biological consequences of integrin alpha v beta 3-mediated melanoma cell adhesion to fibrinogen and its plasmic fragments.

1992 • 83 citations

Differential Regulation of Protein-tyrosine Phosphatases by Integrin αIIbβ3 through Cytoskeletal Reorganization and Tyrosine Phosphorylation in Human Platelets

1995 • 81 citations

The Cytoplasmic Domain of αIIbβ3

1996 • 75 citations

The Amino-terminal One-third of αIIb Defines the Ligand Recognition Specificity of Integrin αIIbβ3

1996 • 73 citations

Leukocytes from four patients with complete or partial Leu-CAM deficiency contain the common beta-subunit precursor and beta-subunit messenger RNA.

1987 • 71 citations

Soluble Ligands of the αvβ4 Integrin Mediate Enhanced Tyrosine Phosphorylation of Multiple Proteins in Adherent Bovine Pulmonary Artery Endothelial Cells

1995 • 71 citations

The alpha v beta 3 integrin associates with a 190-kDa protein that is phosphorylated on tyrosine in response to platelet-derived growth factor

1993 • 70 citations

Expression and Modulation of the Vitronectin Receptor on Human Dermal Microvascular Endothelial Cells

1992 • 70 citations

Inducible Tyrosine Phosphorylation of the β3 Integrin Requires the αv Integrin Cytoplasmic Tail

1996 • 67 citations

Involvement of α6β3 Integrin in Mediating Fibrin Gel Retraction

1995 • 65 citations

The vitronectin receptor (αvβ3) is implicated, in cooperation with P-selectin and platelet-activating factor, in the adhesion of monocytes to activated endothelial cells

1994 • 65 citations

Beta 3 integrin-mediated fibrin clot retraction by nucleated cells: differing behavior of alpha IIb beta 3 and alpha v beta 3

1995 • 65 citations

Non-Receptor Protein Tyrosine Kinases and Phosphatases in Human Platelets

1996 • 64 citations

Clustering of vitronectin and RGD peptides on microspheres leads to engagement of integrins on the luminal aspect of endothelial cell membrane

1994 • 62 citations

Type 1 Plasminogen Activator Inhibitor Induces Multimerization of Plasma Vitronectin

1996 • 58 citations

Labeling of integrin alpha v beta 3 with 58Co(III). Evidence of metal ion coordination sphere involvement in ligand binding

1991 • 58 citations

Evidence That the Integrin β3 and β5 Subunits Contain a Metal Ion-dependent Adhesion Site-like Motif but Lack an I Domain

1997 • 57 citations

Beta 3 integrin-mediated fibrin clot retraction by nucleated cells: differing behavior of alpha IIb beta 3 and alpha v beta 3

1995 • 57 citations

A beta turn in the cytoplasmic tail of the integrin alpha v subunit influences conformation and ligand binding of alpha v beta 3.

1994 • 57 citations

The mouse vitronectin receptor is a T cell activation antigen.

1991 • 52 citations

The role of the integrin vitronectin receptor, ?v?3 in melanoma metastasis

1995 • 51 citations

Murine T cells express a cell surface receptor for multiple extracellular matrix proteins. Identification and characterization with monoclonal antibodies.

1989 • 50 citations

The localization of a platelet GpIIb-IIIa-related protein in endothelial cell adhesion structures

1988 • 49 citations

Regulation of integrin‐mediated adhesion at focal contacts by cyclic AMP

1993 • 46 citations

Blockade of osteoclast‐mediated bone resorption through occupancy of the integrin receptor: A potential approach to the therapy of osteoporosis

1994 • 42 citations

Solid-phase von Willebrand factor contains a conformationally active RGD motif that mediates endothelial cell adhesion through the alpha v beta 3 receptor

1993 • 37 citations

Antigen-independent, integrin-mediated T cell activation.

1995 • 35 citations

Localization of 13-hydroxyoctadecadienoic acid and the vitronectin receptor in human endothelial cells and endothelial cell/platelet interactions in vitro

1993 • 34 citations

Isolation of Leukocyte Response Integrin: A Novel RGD-Binding Protein Involved in Regulation of Phagocytic Function

1993 • 33 citations

Platelet tyrosine kinases and fibrinogen receptor activation.

1994 • 30 citations

Continued platelet interaction with de-endothelialized aortae associated with slower re-endothelialization and more extensive intimal hyperplasia in spontaneously diabetic BB Wistar rats.

1993 • 22 citations

Blood leukocytes bind platelet glycoprotein (lIb-Ilia)' but do not express the vitronectin receptor

1990 • 22 citations

Neointima Formation in Injured Hamster Carotid Artery Is Effectively Prevented by the Combination G4120 and Quinapril

1996 • 15 citations

Modulation of α5β1 and αVβ3 integrins on the cell surface during mitosis

1996 • 15 citations

Characterization of adhesion of non-exogenously stimulated and resting platelets in normal plasma to fibrinogen and its fragments

1994 • 8 citations

713-1 inhibition of Neointimal Hyperplasia After Balloon Injury by Local Delivery of a Cyclic Arginine-Glycine-Aspartic Acid Peptide Targeting Vitronectin Receptor

1995 • 5 citations