Ex Vivo Models for Studying Thrombosis: Special Emphasis on Shear Rate Dependent Blood-Collagen Interactions

Flow Effects on Prostacyclin Production by Cultured Human Endothelial Cells

1985 • 1,237 citations

Tissue factor and hemostasis [published erratum appears in Blood 1988 Apr;71(4):1178]

1988 • 941 citations

The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein.

1975 • 856 citations

[2] Preparation and characterization of the different types of collagen

1982 • 758 citations

Tissue factor and hemostasis [published erratum appears in Blood 1988 Apr;71(4):1178]

1988 • 670 citations

Human blood platelet adhesion to artery subendothelium is mediated by factor VIII–Von Willebrand factor bound to the subendothelium

1979 • 652 citations

Platelets in Biology and Pathology

1981 • 644 citations

Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation.

1986 • 609 citations

The role of blood flow in platelet adhesion, fibrin deposition, and formation of mural thrombi

1973 • 587 citations

Inhibition of platelet prostaglandin synthetase by oral aspirin.

1978 • 552 citations

The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action

1988 • 482 citations

Properties of the factor Xa binding site on human platelets.

1978 • 443 citations

Heparin induces release of extrinsic: Coagulation pathway inhibitor (EPI)

1988 • 401 citations

A perfusion chamber developed to investigate platelet interaction in flowing blood with human vessel wall cells, their extracellular matrix, and purified components.

1983 • 382 citations

Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. I. Shear rate--dependent decrease of adhesion in von Willebrand's disease and the Bernard-Soulier syndrome.

1978 • 368 citations

Progress in Hemostasis and Thrombosis.

1974 • 349 citations

Blood platelets are concentrated near the wall and red blood cells, in the center in flowing blood.

1988 • 323 citations

Influence of arterial damage and wall shear rate on platelet deposition. Ex vivo study in a swine model.

1986 • 293 citations

Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone.

1988 • 274 citations

Platelet Adhesion, Release and Aggregation in Flowing Blood: Effects of Surface Properties and Platelet Function.

1976 • 264 citations

Evidence that three adhesive proteins interact with a common recognition site on activated platelets.

1984 • 254 citations

The role of platelet membrane glycoproteins Ib and IIb-IIIa in platelet adherence to human artery subendothelium

1986 • 237 citations

Collagen characterisation and cell transformation in human atherosclerosis

1975 • 223 citations

Platelet adhesion and thrombus formation on subendothelium in platelets deficient in glycoproteins IIb-IIIa, Ib, and storage granules

1986 • 215 citations

Heparin inhibition of von Willebrand factor-dependent platelet function in vitro and in vivo.

1991 • 208 citations

Studies of a mechanism inhibiting the initiation of the extrinsic pathway of coagulation

1987 • 200 citations

Platelet adhesion and thrombus formation on subendothelium in platelets deficient in glycoproteins IIb-IIIa, Ib, and storage granules

1986 • 170 citations

Role of shear rate and platelets in promoting fibrin formation on rabbit subendothelium. Studies utilizing patients with quantitative and qualitative platelet defects.

1986 • 169 citations

Effects of monoclonal antibodies against the platelet glycoprotein IIb/IIIa complex on thrombosis and hemostasis in the baboon.

1988 • 167 citations

Collagens in Atherosclerosis

1985 • 165 citations

Platelet interaction with rabbit subendothelium in von Willebrand's disease: altered thrombus formation distinct from defective platelet adhesion.

1984 • 153 citations

Evidence for the presence of tissue factor activity on subendothelium

1989 • 141 citations

Hirudin interruption of heparin-resistant arterial thrombus formation in baboons

1991 • 139 citations

Relative distribution of fibronectin and type I, III, IV, V collagens in normal and atherosclerotic intima of human arteries

1987 • 139 citations

Impaired factor X and prothrombin activation associated with decreased phospholipid exposure in platelets from a patient with a bleeding disorder

1985 • 135 citations

Characterization of the inhibition of tissue factor in serum

1987 • 134 citations

Inhibition of platelet-dependent thrombus formation by human activated protein C in a primate model

1989 • 133 citations

Eine neue Methode zur Erzeugung von Thromben durch gezielte Überdehnung der Gefäßwand

1963 • 130 citations

Platelets in Biology and Pathology

1977 • 126 citations

Progress in Hemostasis and Thrombosis.

1983 • 124 citations

Platelet interactions with Dacron vascular grafts. A model of acute thrombosis in baboons.

1985 • 124 citations

Inhibition of thrombus formation by activated recombinant protein C in a primate model of arterial thrombosis.

1990 • 122 citations

Characterization of a tubular flow chamber for studying platelet interaction with biologic and prosthetic materials: deposition of indium 111-labeled platelets on collagen, subendothelium, and expanded polytetrafluoroethylene.

1987 • 117 citations

An inhibitory monoclonal antibody against human tissue factor

1987 • 107 citations

Collagen type III induced ex vivo thrombogenesis in humans. Role of platelets and leukocytes in deposition of fibrin.

1990 • 104 citations

[5] Measurements of platelet interaction with components of the vessel wall in flowing blood

1989 • 91 citations

Factors Controlling Thrombus Formation on Arterial Lesions

1985 • 89 citations

An inhibitory monoclonal antibody against human tissue factor

1987 • 83 citations

Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. II. Relationships among platelet adhesion, thrombus dimensions, and fibrin formation.

1980 • 81 citations

High‐resolution analysis of the modified quarter‐stagger model of the collagen fibril

1974 • 76 citations

Factor VIII-von Willebrand factor requires calcium for facilitation of platelet adherence

1984 • 75 citations

Discrimination between platelet-mediated and coagulation-mediated mechanisms in a model of complex thrombus formation in vivo.

1989 • 72 citations

Rheological Factors Influencing Platelet Interaction with Vessel Surfaces

1979 • 65 citations

von Willebrand factor-mediated platelet adhesion to collagen involves platelet membrane glycoprotein IIb-IIIa as well as glycoprotein Ib.

1988 • 64 citations

Effects of red blood cell concentration on hemostasis and thrombus formation in a primate model

1990 • 63 citations

Growth and Stability of Thrombi in Flowing Citrated Blood: Assessment of Platelet-Surface Interactions with Computer-Assisted Morphometry

1988 • 62 citations

Automated microdensitometry and protein assays as a measure for platelet adhesion and aggregation on collagen-coated slides under controlled flow conditions.

1980 • 61 citations

Shear rate-dependent impairment of thrombus growth on collagen in nonanticoagulated blood from patients with von Willebrand disease and hemophilia A

1992 • 60 citations

Further Evidence that Glycoprotein IIb-IIIa Mediates Platelet Spreading on Subendothelium

1991 • 58 citations

ADVANCES IN PHARMACOLOGY AND THERAPEUTICS II

1982 • 58 citations

The anticoagulant effect in heparinized blood and plasma resulting from interactions with extrinsic pathway inhibitor

1991 • 58 citations

Axial dependence of platelet-collagen interactions in flowing blood. Upstream thrombus growth impairs downstream platelet adhesion.

1989 • 56 citations

Role of Platelet Membrane Glycoproteins and Von Willebrand Factor in Adhesion of Platelets to Subendothelium and Collagen

1987 • 51 citations

Fibrin formation, fibrinopeptide A release, and platelet thrombus dimensions on subendothelium exposed to flowing native blood: greater in factor XII and XI than in factor VIII and IX deficiency

1984 • 51 citations

Regulation of Thrombin Generation at Cell Surfaces

1988 • 48 citations

RGDV peptide selectively inhibits platelet-dependent thrombus formation in vivo. Studies using a baboon model.

1989 • 47 citations

Effect of aspirin and epinephrine on experimentally induced thrombogenesis in dogs. A parallelism between in vivo and ex vivo thrombosis models.

1991 • 47 citations

Mass transfer in annuli under conditions of laminar flow

1975 • 44 citations

Inhibition of platelet-dependent thrombosis by low molecular weight heparin (CY222): comparison with standard heparin.

1989 • 43 citations

Interaction of thrombasthenic platelets with subendothelium: Normal adhesion, absent aggregation

1975 • 38 citations

Effects of anticoagulation on the interaction of human platelets with subendothelium in flowing blood.

1976 • 38 citations

Effects of Acetylsalicylic Acid, Sulfinpyrazone and Dipyridamole on Platelet Adhesion and Aggregation in Flowing Native and Anticoagulated Blood

1979 • 37 citations

Platelet aggregation in flowing blood at a site of injury to an endothelial cell monolayer: quantitation and real-time imaging with the TAB monoclonal antibody

1990 • 34 citations

Effect of Aspirin and Dipyridamole on the Interaction of Human Platelets with Sub-Endothelium: Studies Using Citrated and Native Blood

1981 • 30 citations

Excessive Deposition of Fibrin, Platelets and Platelet Thrombi on Vascular Subendothelium During Contraceptive Drug Treatment

1987 • 30 citations

Selective inhibition by a synthetic hirudin peptide of fibrin-dependent thrombosis in baboons.

1991 • 29 citations

Upstream Thrombus Growth Impairs Downstream Thrombogenesis in Non-Anticoagulated Blood: Effect of Procoagulant Artery Subendothelium and Non-Procoagulant Collagen

1991 • 25 citations

Regulation of Platelet‐Fibrin Thrombi on Subendotheliuma

1987 • 25 citations

Velocity profiles in annular perfusion chamber measured by laser-Doppler velocimetry

1984 • 20 citations

Procoagulant activity of endotoxin-treated human endothelial cells exposed to native human flowing blood

1989 • 19 citations

Relationship Between Fibrinopeptide A and Fibrinogen/Fibrin Fragment E in Thromboembolism, DIC and Various Non-Thromboembolic Diseases

1987 • 18 citations

Role of von Willebrand Factor in Platelet Vessel‐Wall Interactions

1987 • 17 citations

Procoagulant activity of endotoxin-treated human endothelial cells exposed to native human flowing blood

1989 • 15 citations

Hemostasis and Thrombosis

2008 • 12 citations

Platelet interactions with Dacron vascular grafts: A model of acute thrombosis in baboons

1987 • 11 citations

Effect of Physical Factors on Platelet Adhesion to Subendothelium

1976 • 8 citations