Hepsin, a Putative Membrane-associated Serine Protease, Activates Human Factor VII and Initiates a Pathway of Blood Coagulation on the Cell Surface Leading to Thrombin Formation

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Preparative and analytical purification of DNA from agarose.

1979 • 1,585 citations

Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation.

1977 • 791 citations

Vectors that facilitate the expression and purification of foreign peptides in Escherichia coli by fusion to maltose-binding protein

1988 • 662 citations

Human Plasma Protein C

1979 • 511 citations

A Brain Extract as a Substitute for Platelet Suspensions in the Thromboplastin Generation Test

1954 • 489 citations

Characterization of a cDNA coding for human factor VII.

1986 • 450 citations

Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells

1988 • 270 citations

Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function

1991 • 228 citations

Isolation and characterization of cancer procoagulant: a cysteine proteinase from malignant tissue

1985 • 213 citations

The contributions of Ca2+, phospholipids and tissue-factor apoprotein to the activation of human blood-coagulation factor X by activated factor VII

1990 • 193 citations

Proteolytic activation of human factors IX and X by recombinant human factor VIIa: effects of calcium, phospholipids, and tissue factor

1990 • 188 citations

A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells

1988 • 174 citations

Measurement of basal levels of factor VIIa in hemophilia A and B patients [see comments]

1992 • 166 citations

Initiation of the extrinsic pathway of blood coagulation: evidence for the tissue factor dependent autoactivation of human coagulation factor VII

1991 • 129 citations

Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization.

1991 • 112 citations

[49] Preparation of polyclonal antibodies

1990 • 106 citations

Fibrin and Cancer

1993 • 100 citations

Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth.

1993 • 99 citations

Purification and characterization of human factor II

1973 • 96 citations

Lipid association, but not the transmembrane domain, is required for tissue factor activity. Substitution of the transmembrane domain with a phosphatidylinositol anchor.

1991 • 89 citations

Factor VIIa-catalyzed activation of factor X independent of tissue factor: its possible significance for control of hemophilic bleeding by infused factor VIIa

1990 • 85 citations

The C-terminus of tissue factor pathway inhibitor (TFPI) is essential to its anticoagulant activity

1991 • 84 citations

Human monocytes support factor X activation by factor VIIa, independent of tissue factor: implications for the therapeutic mechanism of high- dose factor VIIa in hemophilia [see comments]

1994 • 72 citations

Activation of human factor VII by factors IXa and Xa on human bladder carcinoma cells

1989 • 60 citations

Evidence that plasma lipoproteins inhibit the factor VIIa-tissue factor complex by a different mechanism that extrinsic pathway inhibitor

1987 • 55 citations

Synthesis, purification, and characterization of an Arg152 .fwdarw. Glu site-directed mutant of recombinant human blood clotting factor VII

1990 • 50 citations

Fibrinogen-fibrin transformation in situ in renal cell carcinoma.

1990 • 46 citations

Coagulation and cancer

1991 • 42 citations

Human Tumor Procoagulants: Registry of the Subcommittee on Haemostasis and Malignancy of the Scientific and Standardization Committee, International Society on Thrombosis and Haemostasis

1993 • 41 citations

Isolation and characterization of proteolytic fragments of human factor VIIa which inhibit the tissue factor-enhanced amidolytic activity of factor VIIa

1993 • 40 citations

Formation and Dissociation of the Covalent Complexes Between Trypsin and Two Homologous Inhibitors, alpha1-Antitrypsin and Antithrombin III

1980 • 39 citations

Endoproteolytic processing of the human protein C precursor by the yeast Kex2 endopeptidase coexpressed in mammalian cells

1991 • 39 citations

The Role of Phospholipids and the Factor VII Gla-Domain in the Interaction of Factor VII with Tissue Factor

1992 • 38 citations

Isolation and characterization of an intracellular serine proteinase inhibitor from a monkey kidney epithelial cell line.

1993 • 34 citations

Cellular Localization of Activated Factor X by Xa-Specific Probes

1991 • 29 citations

Generation of Gla‐domainless FVIIa by cathepsin G‐mediated cleavage

1992 • 29 citations

Hemorrhagic Disease and Thrombosis.

1967 • 19 citations