A set of inducible genes expressed by activated human monocytic and endothelial cells contain kappa B-like sites that specifically bind c-Rel-p65 heterodimers.

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

Establishment and characterization of a human acute monocytic leukemia cell line (THP‐1)

1980 • 2,158 citations

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.

1990 • 826 citations

Regulation of the NF-ηB/rel transcription factor and IηB inhibitor system

1993 • 541 citations

Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion.

1993 • 525 citations

NF-κB Subunit-Specific Regulation of the Interleukin-8 Promoter

1993 • 504 citations

Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation

1992 • 501 citations

Nuclear factor kappa B, a mediator of lipopolysaccharide effects

1993 • 476 citations

Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1).

1992 • 476 citations

Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells.

1984 • 455 citations

Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines.

1990 • 384 citations

Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites.

1991 • 373 citations

NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit.

1991 • 287 citations

12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter.

1994 • 266 citations

An NFxB-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription

1991 • 245 citations

Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells

1993 • 239 citations

NF-kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene.

1990 • 205 citations

A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene.

1992 • 171 citations

International Review of Cytology

1961 • 156 citations

Cell-free pool of CD14 mediates activation of transcription factor NF-kappa B by lipopolysaccharide in human endothelial cells.

1993 • 135 citations

Regulatory elements responsible for inducible expression of the granulocyte colony-stimulating factor gene in macrophages.

1990 • 122 citations

Lipopolysaccharide Induction of Tissue Factor Gene Expression in Monocytic Cells Is Mediated by Binding of c-Rel/p65 Heterodimers to a κB-Like Site

1994 • 118 citations

HTLV-1 tax activation of the GM-CSF and G-CSF promoters requires the interaction of NF-kB with other transcription factor families.

1993 • 87 citations

A novel tumor necrosis factor-responsive transcription factor which recognizes a regulatory element in hemopoietic growth factor genes.

1990 • 67 citations

Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription.

1994 • 58 citations

Involvement of a nuclear factor-kappa B-like protein in induction of the macrophage colony-stimulating factor gene by tumor necrosis factor

1991 • 38 citations