Adenosine-dopamine interactions in the brain

The functional anatomy of basal ganglia disorders

1989 • 5,166 citations

Functional architecture of basal ganglia circuits: neural substrates of parallel processing

1990 • 4,029 citations

Primate models of movement disorders of basal ganglia origin

1990 • 3,722 citations

D ₁ and D ₂ Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons

1990 • 2,873 citations

Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,922 citations

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

Cloning and expression of a rat D2 dopamine receptor cDNA

1988 • 1,125 citations

The effect of adenosine and adenine nucleotides on the cyclic adenosine 3', 5'-phosphate content of guinea pig cerebral cortex slices.

1970 • 860 citations

Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.

1986 • 821 citations

Quantitative autoradiographic localization of the D1 and D2 subtypes of dopamine receptors in rat brain

1986 • 742 citations

Adenosine receptors and behavioral actions of methylxanthines.

1981 • 705 citations

Selective Amplification And Cloning Of Four New Members Of The G Protein-coupled Receptor Family

1989 • 647 citations

The Physiological Role of Adenosine In The Central Nervous System

1985 • 628 citations

Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranes.

1991 • 541 citations

[3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain.

1989 • 537 citations

Striatal Restricted Adenosine A₂ Receptor (RDC8) Is Expressed by Enkephalin but Not by Substance P Neurons: An In Situ Hybridization Histochemistry Study

1991 • 527 citations

Modulation of neurotransmission by purine nucleotides and nucleosides

1980 • 526 citations

Phenotypical characterization of the rat striatal neurons expressing the D1 dopamine receptor gene.

1991 • 477 citations

Dopamine receptor gene expression by enkephalin neurons in rat forebrain.

1990 • 469 citations

Adenosine as a Neuromodulator

1985 • 462 citations

Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines

1983 • 437 citations

The striatal cholinergic interneuron: Synaptic target of dopaminergic terminals?

1983 • 422 citations

Are methylxanthine effects due to antagonism of endogenous adenosine?

1979 • 419 citations

Effect of ergot drugs on central catecholamine neurons: Evidence for a stimulation of central dopamine neurons

1973 • 394 citations

Functional Role of the Nigro‐Neostriatal Dopamine Neurons*)

1966 • 394 citations

Purine levels in the intact rat brain. Studies with an implanted perfused hollow fibre

1982 • 390 citations

Direct autoradiographic localization of adenosine A2 receptors in the rat brain using the A2-selective agonist, [3H]CGS 21680

1989 • 344 citations

The distribution of adenosine a1 receptors and 5'-nucleotidase in the brain of some commonly used experimental animals

1987 • 322 citations

Mechanisms of signal transduction at the dopamine D2 receptor

1989 • 312 citations

Brain adenosine concentration during hypoxia in rats

1981 • 299 citations

RDC8 codes for an adenosine A2 receptor with physiological constitutive activity

1990 • 270 citations

Anxiety or Caffeinism: A Diagnostic Dilemma

1974 • 264 citations

CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity.

1989 • 245 citations

Characterization of dopamine receptors mediating inhibition of adenylate cyclase activity in rat striatum.

1985 • 236 citations

Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides

1979 • 222 citations

Effects of adenosine on depolarization-induced release of various radiolabelled neurotransmitters from slices of rat corpus striatum

1979 • 210 citations

Chemical neurotransmission 75 Years

1982 • 199 citations

Adenosine A2 receptors: Selective localization in the human basal ganglia and alterations with disease

1991 • 198 citations

D2 dopamine receptor gene expression by cholinergic neurons in the rat striatum

1990 • 191 citations

Effects of the selective adenosine A2 receptor agonist CGS 21680 on in vitro electrophysiology, cAMP formation and dopamine release in rat hippocampus and striatum.

1990 • 167 citations

Action of caffeine and theophyllamine on supersensitive dopamine receptors: considerable enhancement of receptor response to treatment with DOPA and dopamine receptor agonists.

1974 • 166 citations

Huntington's disease

1984 • 165 citations

Adenosine modulation of synaptosomal dopamine release

1979 • 158 citations

Modulation by cholecystokinins of ³H‐spiroperidol binding in rat striatum: evidence for increased affinity and reduction in the number of binding sites

1981 • 155 citations

Receptor‐receptor interactions in the central nervous system. A new integrative mechanism in synapses

1985 • 155 citations

Autoradiographic evidence for G-protein coupled A2-receptors in rat neostriatum using [3H]-CGS 21680 as a ligand

1990 • 154 citations

BASAL GANGLIA DISEASE

1982 • 150 citations

Adenosine stimulates glycogenolysis in mouse cerebral cortex: a possible coupling mechanism between neuronal activity and energy metabolism

1986 • 129 citations

Adenosine and adenosine triphosphate decrease 45Ca uptake by synaptosomes stimulated by potassium

1979 • 124 citations

The cellular localization of adenosine receptors in rat neostriatum

1989 • 123 citations

Reinforcing effects of caffeine in humans.

1988 • 120 citations

Postsynaptic dopamine/adenosine interaction: I. Adenosine analogues inhibit dopamine D2-mediated behaviour in short-term reserpinized mice

1991 • 118 citations

Interactions of the bovine brain A1-adenosine receptor with recombinant G protein alpha-subunits. Selectivity for rGi alpha-3.

1991 • 116 citations

Stimulation of adenosine A2 receptors induces catalepsy

1991 • 111 citations

Reinforcing properties of caffeine: Studies in humans and laboratory animals

1988 • 110 citations

On the mechanism by which methylxanthines enhance apomorphine-induced rotation behaviour in the rat

1983 • 106 citations

Dopamine denervation leads to an increase in the intramembrane interaction between adenosine A2 and dopamine D2 receptors in the neostriatum

1992 • 104 citations

Modulation of Striatal Dopaminergic Function by Local Injection of 5′- N -Ethylcarboxamide Adenosine

1982 • 104 citations

Postsynaptic dopamine/adenosine interaction: II. Postsynaptic dopamine agonism and adenosine antagonism of methylxanthines in short-term reserpinized mice

1991 • 103 citations

Comparison of the behavioral effects of adenosine agonists and dopamine antagonists in mice

1989 • 101 citations

Stereospecificity in some central and circulatory effects of phenylisopropyl-adenosine (PIA).

1975 • 99 citations

Caffeine produces contralateral rotation in rats with unilateral dopamine denervation: comparisons with apomorphine-induced responses

1988 • 97 citations

Effects of Caffeine and Theophylline on Activity of Rats in Relation to Brain Xanthine Concentrations

1972 • 97 citations

Effect of some phosphodiesterase inhibitors on central dopamine mechanisms

1976 • 95 citations

Autoradiographic characterization of high-affinity adenosine A2 receptors in the rat brain

1989 • 94 citations

Adenosine and adenosine receptors

1991 • 92 citations

Qualitative differences in the discriminative stimulus effects of low and high doses of caffeine in the rat.

1991 • 89 citations

Brain adenosine production in rat during sustained alteration in systemic blood pressure

1980 • 88 citations

Central versus peripheral mediation of responses to adenosine receptor agonists: Evidence against a central mode of action

1987 • 84 citations

Evidence for adenosine A2 receptor involvement in the hypomobility effects of adenosine analogues in mice

1989 • 80 citations

Adenosine-sensitive adenylate cyclase in rat brain homogenates: kinetic characteristics, specificity, topographical, subcellular and cellular distribution.

1979 • 78 citations

Adenosinergic modulation of caffeine-induced c-fos mRNA expression in mouse brain

1989 • 70 citations

Sensitization by caffeine of central catecholamine receptors

1973 • 70 citations

Comparison of the behavioural effects of an adenosine A1/A2-receptor antagonist, CGS 15943A, and an A1-selective antagonist, DPCPX

1991 • 70 citations

Expression of dopamine D2 receptor and choline acetyltransferase mRNA in the dopamine deafferented rat caudate-putamen

1990 • 66 citations

Neurotensin reduces the affinity of D‐2 dopamine receptors in rat striatal membranes

1987 • 65 citations

Evidence that adenosine A2 and dopamine autoreceptors antagonistically regulate tyrosine hydroxylase activity in rat striatal synaptosomes

1988 • 64 citations

Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor

1991 • 64 citations

Inhibition of nigrostriatal release of dopamine in the rat by adenosine receptor agonists: A1 receptor mediation

1989 • 60 citations

Striatal A2 receptor regulates apomorphine-induced turning in rats with unilateral dopamine denervation

1991 • 59 citations

Cholecystokinin peptides in vitro modulate the characteristics of the striatal ³H‐N‐propylnorapomorphine sites

1983 • 59 citations

Neuropharmacological Profile of Cholecystokinin‐like Peptides

1985 • 59 citations

Behavioral effects of nicotine: schedule-controlled responding by squirrel monkeys.

1981 • 55 citations

Presynaptic Adenosine A₂ and N‐Methyl‐D‐Aspartate Receptors Regulate Dopamine Synthesis in Rat Striatal Synaptosomes

1991 • 55 citations

Characterization of the locomotor depression produced by an A₂‐selective adenosine agonist

1990 • 52 citations

Dissociation of the locomotor and hypotensive effects of adenosine analogues in the rat

1984 • 51 citations

Behavioral effects of intrastriatal caffeine mediated by adenosinergic modulation of dopamine

1991 • 50 citations

Decrease in rat straital dopamine synthesis and metabolism in vivo by metabolically stable adenosine receptor agonists

1986 • 45 citations

Relationship between rotational behaviour induced by apomorphine and caffeine in rats with unilateral lesion of the nigrostriatal pathway

1989 • 45 citations

Monoamine synthesis and caffeine-induced locomotor activity

1978 • 44 citations

Activation of adenylate cyclase from rat striatum and tuberculum olfactorium by adenosine.

1977 • 43 citations

Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism

1988 • 42 citations

Effects of adult or neonatal treatment with 6-hydroxydopamine or 5,7-dihydroxytryptamine on locomotor activity, monoamine levels, and response to caffeine

1986 • 40 citations

Adenosine and Adenine Nucleotides

2015 • 37 citations

Methylxanthine effects on caudate dopamine release as measured by electrochemistry

1989 • 36 citations

NECA-induced hypomotility in mice: Evidence for a predominantly central site of action

1989 • 35 citations

Adenosine in Central Nervous System Function

1990 • 33 citations

Subcortical limbic 3H-N-propylnorapomorphine binding sites are markedly modulated by cholecystokinin-8 in vitro

1983 • 31 citations

The effect of caffeine, theophylline and amphetamine on operant responding of the mouse

1980 • 31 citations

l-glutamate reduces the affinity of [3H]N-propylnorapomorphine binding sites in striatal membranes

1984 • 29 citations

Phosphorylation by Cyclic AMP‐Dependent Protein Kinase Modulates Agonist Binding to the D₂ Dopamine Receptor

1991 • 27 citations

Paraxanthine displaces the binding of [3H]SCH 23390 from rat striatal membranes

1990 • 24 citations

Modulation of Dopamine D1 and D2 Transmission Lines in the Central Nervous System

1990 • 22 citations

CNS distribution of D1 receptors: Use of a new specific D1 receptor antagonist, [3H]SCH39166

1992 • 19 citations

Prospective role for adenosine and adenosinergic systems in psychiatric disorders

1990 • 19 citations

Rotational behaviour induced by theophylline in 6-OHDA nigrostriatal denervated rats is dependent on the supersensitivity of striatal dopaminergic receptors

1989 • 17 citations

Effects of selected analogs of adenosine on schedule-controlled behavior in rats

1986 • 16 citations

Behavioural effects of selective A2 adenosine receptor antagonists, CGS 21197 and CGS 22706, in mice

1991 • 16 citations

Adenosine and adenine nucleotides: Physiology and pharmacology

1988 • 15 citations

The Psychobiology of Neurotensin

1988 • 15 citations

Effects of Mu receptor agonists and droperidol on motor coordination in mice

1988 • 14 citations

Formation and Actions of Adenosine in the Rat Hippocampus, with Special Reference to the Interactions with Classical Transmitters

1988 • 8 citations

Analogs of Caffeine and Theophylline: Activity as Antagonists at Adenosine Receptors

1990 • 8 citations

A trypsin inhibitor-like peptide PEC-60 reduces the affinity of dopamine D2 agonist binding sites in rat neostriatal membranes

1991 • 7 citations

Deleted Work

1955 • 0 citations