Antagonistic A_2a/D₂ receptor interactions in the striatum as a basis for adenosine/dopamine interactions in the central nervous system

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,922 citations

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranes.

1991 • 541 citations

[3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain.

1989 • 537 citations

Striatal Restricted Adenosine A₂ Receptor (RDC8) Is Expressed by Enkephalin but Not by Substance P Neurons: An In Situ Hybridization Histochemistry Study

1991 • 527 citations

Dopamine receptor gene expression by enkephalin neurons in rat forebrain.

1990 • 469 citations

Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines

1983 • 437 citations

Are methylxanthine effects due to antagonism of endogenous adenosine?

1979 • 419 citations

Mechanisms of signal transduction at the dopamine D2 receptor

1989 • 312 citations

RDC8 codes for an adenosine A2 receptor with physiological constitutive activity

1990 • 270 citations

CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity.

1989 • 245 citations

Physiological and regulatory functions of adenosine and adenine nucleotides

1980 • 228 citations

Adenosine A2 receptors: Selective localization in the human basal ganglia and alterations with disease

1991 • 198 citations

D2 dopamine receptor gene expression by cholinergic neurons in the rat striatum

1990 • 191 citations

Effects of the selective adenosine A2 receptor agonist CGS 21680 on in vitro electrophysiology, cAMP formation and dopamine release in rat hippocampus and striatum.

1990 • 167 citations

Receptor‐receptor interactions in the central nervous system. A new integrative mechanism in synapses

1985 • 155 citations

Autoradiographic evidence for G-protein coupled A2-receptors in rat neostriatum using [3H]-CGS 21680 as a ligand

1990 • 154 citations

Postsynaptic dopamine/adenosine interaction: I. Adenosine analogues inhibit dopamine D2-mediated behaviour in short-term reserpinized mice

1991 • 118 citations

Stimulation of adenosine A2 receptors induces catalepsy

1991 • 111 citations

Is experimental catalepsy properly measured?

1990 • 109 citations

On the mechanism by which methylxanthines enhance apomorphine-induced rotation behaviour in the rat

1983 • 106 citations

Dopamine denervation leads to an increase in the intramembrane interaction between adenosine A2 and dopamine D2 receptors in the neostriatum

1992 • 104 citations

Modulation of Striatal Dopaminergic Function by Local Injection of 5′- N -Ethylcarboxamide Adenosine

1982 • 104 citations

Postsynaptic dopamine/adenosine interaction: II. Postsynaptic dopamine agonism and adenosine antagonism of methylxanthines in short-term reserpinized mice

1991 • 103 citations

Caffeine produces contralateral rotation in rats with unilateral dopamine denervation: comparisons with apomorphine-induced responses

1988 • 97 citations

Effect of some phosphodiesterase inhibitors on central dopamine mechanisms

1976 • 95 citations

Autoradiographic characterization of high-affinity adenosine A2 receptors in the rat brain

1989 • 94 citations

Regulation of ligand binding to pituitary D-2 dopaminergic receptors. Effects of divalent cations and functional group modification.

1983 • 78 citations

Sensitization by caffeine of central catecholamine receptors

1973 • 70 citations

Crotaline pit organs analyzed as warm receptors

1981 • 69 citations

Striatal A2 receptor regulates apomorphine-induced turning in rats with unilateral dopamine denervation

1991 • 59 citations

Behavioral effects of intrastriatal caffeine mediated by adenosinergic modulation of dopamine

1991 • 50 citations

Monoamine synthesis and caffeine-induced locomotor activity

1978 • 44 citations

Effects of adult or neonatal treatment with 6-hydroxydopamine or 5,7-dihydroxytryptamine on locomotor activity, monoamine levels, and response to caffeine

1986 • 40 citations

Stimulation of D₁ dopamine receptors reveals direct effects of the preferential dopamine autoreceptor agonist B‐HT 920 on postsynaptic dopamine receptors

1988 • 27 citations

Phosphorylation by Cyclic AMP‐Dependent Protein Kinase Modulates Agonist Binding to the D₂ Dopamine Receptor

1991 • 27 citations