APP peptides stimulate lymphocyte proliferation in normals, but not in patients with Alzheimer's Disease

“Mini-mental state”

1975 • 82,784 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

1984 • 1,633 citations

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

1990 • 1,361 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Admission criteria for immunogerontological studies in man: The senieur protocol

1984 • 754 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Amyloidosis (AL). Clinical and laboratory features in 229 cases.

1983 • 603 citations

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

1988 • 584 citations

Cell Death Mechanisms and the Immune System

1991 • 459 citations

Isolation of Low‐Molecular‐Weight Proteins from Amyloid Plaque Fibers in Alzheimer's Disease

1986 • 443 citations

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

1992 • 432 citations

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.

1994 • 338 citations

The amyloid precursor protein of Alzheimer's disease is released by human platelets.

1990 • 322 citations

Technical tips

1994 • 192 citations

Retrobulbar T cells from patients with Graves' ophthalmopathy are CD8+ and specifically recognize autologous fibroblasts.

1994 • 143 citations

Emerging Role of Heat Shock Proteins in Biology and Medicine

1992 • 107 citations

Natural Autoantibodies Constitute a Substantial Part of Normal Circulating Immunoglobulins

1986 • 107 citations

Human antibodies reactive with beta-amyloid protein in Alzheimer's disease.

1993 • 83 citations

Complement activation and β-amyloid-mediated neurotoxicity in Alzheimer's disease

1992 • 81 citations

Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21.

1988 • 74 citations

Immunologic dysfunction: simultaneous study of alzheimer's and older down's patients

1986 • 66 citations

Recommended minimum data to be collected in research studies on Alzheimer's disease. The MRC (UK) Alzheimer's Disease Workshop Steering Committee.

1989 • 57 citations

Complement proteins and complement inhibitors in Alzheimer's disease

1992 • 57 citations

Concentrations of amyloid-β protein in cerebrospinal fluid increase with age in patients free from neurodegenerative disease

1994 • 44 citations

Heat shock alters Alzheimer's β amyloid precursor protein expression in human endothelial cells

1994 • 31 citations

Do heat shock proteins play a role in Graves' disease? Heat shock protein-specific T-cells from Graves' disease thyroids do not recognize thyroid epithelial cells.

1993 • 23 citations

Thyroid epithelial cells produce large amounts of the Alzheimer beta-amyloid precursor protein (APP) and generate potentially amyloidogenic APP fragments.

1995 • 17 citations

Do heat shock proteins play a role in Graves' disease? Heat shock protein-specific T-cells from Graves' disease thyroids do not recognize thyroid epithelial cells

1993 • 12 citations

Two signal model of self/not-self immune discrimination: An update

1992 • 8 citations

Autoantibodies and normal antibodies: two sides of the same coin.

1985 • 7 citations

Thyroid epithelial cells produce large amounts of the Alzheimer beta- amyloid precursor protein (APP) and generate potentially amyloidogenic APP fragments

1995 • 6 citations