H₁‐antihistamines: inverse agonism, anti‐inflammatory actions and cardiac effects

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

1995 • 2,391 citations

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

1995 • 2,263 citations

The membrane actions of anesthetics and tranquilizers.

1972 • 2,194 citations

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

1996 • 1,746 citations

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1995 • 1,686 citations

MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia

1999 • 1,344 citations

Cardiac Electrophysiology: From Cell to Bedside

1995 • 1,173 citations

A structural basis for drug-induced long QT syndrome

2000 • 911 citations

International Union of Pharmacology. XIII. Classification of histamine receptors.

1997 • 869 citations

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1993 • 769 citations

Mutations in the hminK gene cause long QT syndrome and suppress lKs function

1997 • 763 citations

Potassium channels: molecular defects, diseases, and therapeutic opportunities.

2000 • 506 citations

The two-state model of receptor activation

1995 • 492 citations

AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration

2000 • 487 citations

High constitutive activity of native H3 receptors regulates histamine neurons in brain

2000 • 459 citations

A Distinct Potassium Channel Polypeptide Encoded by the Drosophila eag Locus

1991 • 361 citations

G-protein-coupled receptors function as oligomers in vivo

2000 • 313 citations

HERG, a Primary Human Ventricular Target of the Nonsedating Antihistamine Terfenadine

1996 • 294 citations

Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

1995 • 285 citations

HERG K+ channels: friend and foe

2001 • 284 citations

Cloning and characterization of a novel human histamine receptor.

2001 • 277 citations

Human skin mast cells: their dispersion, purification, and secretory characterization.

1987 • 274 citations

Cardiac Actions of Antihistamines

1996 • 261 citations

Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: involvement of S6 sites.

2000 • 241 citations

Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors.

1996 • 235 citations

Myocardial Potassium Channels: Electrophysiological and Molecular Diversity

1996 • 230 citations

Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole

1996 • 227 citations

Structural and functional aspects of G protein-coupled receptor oligomerization

1998 • 213 citations

Inhibitory effect of cetirizine 2HCl on eosinophil migration in vivo

1987 • 199 citations

Cardiotoxic effect with convulsions in terfenadine overdose.

1989 • 168 citations

Constitutive activity of the histamine H1 receptor reveals inverse agonism of histamine H1 receptor antagonists

2000 • 162 citations

Torsade de pointes after astemizole overdose.

1986 • 157 citations

Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin

1988 • 147 citations

The displacement of membrane calcium by a local anesthetic (chlorpromazine)

1969 • 140 citations

Structural and functional aspects of G protein-coupled receptor oligomerization

1998 • 140 citations

Cetirizine reduces inflammatory cell recruitment and ICAM-1 (or CD54) expression on conjunctival epithelium in both early- and late-phase reactions after allergen-specific challenge

1995 • 136 citations

Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists.

2001 • 135 citations

Molecular Basis for the Lack of HERG K⁺Channel Block-Related Cardiotoxicity by the H₁Receptor Blocker Cetirizine Compared with Other Second-Generation Antihistamines

1998 • 133 citations

[Ca2+] Oscillation Frequency Regulates Agonist-stimulated NF-κB Transcriptional Activity

1999 • 122 citations

Involvement of the Amino Terminus of the B2 Receptor in Agonist-induced Receptor Dimerization

1999 • 119 citations

Risk of developing life-threatening ventricular arrhythmia associated with terfenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine

1994 • 116 citations

Gi protein modulation induced by a selective inverse agonist for the peripheral cannabinoid receptor CB2: implication for intracellular signalization cross-regulation.

1999 • 114 citations

Topical azelastine reduces eosinophil activation and intercellular adhesion molecule-1 expression on nasal epithelial cells: An antiallergic activity☆☆☆★★★

1996 • 108 citations

Fexofenadine

1998 • 107 citations

INHIBITION OF HISTAMINE RELEASE FROM HUMAN LUNG in vitro BY ANTIHISTAMINES AND RELATED DRUGS

1980 • 106 citations

Novel actions of inverse agonists on 5-HT2C receptor systems.

1999 • 98 citations

Inhibitory effect of cetirizine on the bronchial eosinophil recruitment induced by allergen inhalation challenge in allergic patients with asthma

1992 • 97 citations

Torsade de Pointes with an antihistamine metabolite: Potassium channel blockade with desmethylastemizole

1996 • 94 citations

New Insights into the Second Generation Antihistamines

2001 • 94 citations

Increased expression of histamine H₁ receptor mRNA in allergic rhinitis

1996 • 92 citations

Expression of Histamine Receptors in Nasal Epithelial Cells and Endothelial Cells – The Effects of Sex Hormones

1998 • 89 citations

Cardiotoxic potential and CNS effects of first-generation antihistamines

2000 • 84 citations

Loratadine blockade of K(+) channels in human heart: comparison with terfenadine under physiological conditions.

2000 • 83 citations

Postnatal expression of H₁‐receptor mRNA in the rat brain: correlation to <scp>l</scp>‐histidine decarboxylase expression and local upregulation in limbic seizures

1998 • 80 citations

Effects of H₁antagonists on the cutaneous vascular response to histamine and bradykinin: a study using scanning laser Doppler imaging

1998 • 76 citations

THE ANTI‐ANAPHYLACTIC AND HISTAMINE‐RELEASING PROPERTIES OF THE ANTIHISTAMINES. THEIR EFFECT ON THE MAST CELLS

1960 • 76 citations

Suppression by Azelastine Hydrochloride of NF-/.KAPPA.B Activation Involved in Generation of Cytokines and Nitric Oxide.

1997 • 71 citations

In vitro effects of H₁‐antihistamines on histamine and PGD₂ release from mast cells of human lung, tonsil, and skin

1994 • 70 citations

Azelastine eye drops reduce and prevent allergic conjunctival reaction and exert anti‐allergic activity

1997 • 69 citations

Effects of capsaicin, bradykinin and prostaglandin E2 in the human skin

1992 • 67 citations

Human skin mast cells: in vitro and in vivo studies

1999 • 65 citations

Leukotriene B₄mediates histamine induction of NF-κB and IL-8 in human bronchial epithelial cells

1998 • 63 citations

Block of potassium currents in guinea pig ventricular myocytes and lengthening of cardiac repolarization in man by the histamine H1 receptor antagonist diphenhydramine.

1999 • 62 citations

Cetirizine counter‐regulates interleukin‐8 release from human epithelial cells (A549)

1999 • 61 citations

Ketotifen inhibits the cutaneous but not the airway responses to platelet-activating factor in man

1988 • 60 citations

Loratadine treatment of rhinitis due to pollen allergy reduces epithelial ICAM‐1 expression

1997 • 57 citations

Histamine and H1-receptor antagonists in allergic disease

1997 • 54 citations

Interactions of the Nonsedating Antihistamine Loratadine with a Kv1.5-Type Potassium Channel Cloned from Human Heart

1997 • 48 citations

Platelet-activating factor induces histamine release from human skin mast cells in vivo, which is reduced by local nerve blockade

1997 • 43 citations

Histamine release by antihistamines.

1953 • 43 citations

Histamine receptors are finally ‘coming out’

2001 • 42 citations

Nedocromil sodium and levocabastine reduce the symptoms of conjunctival allergen challenge by different mechanisms

2001 • 40 citations

Inhibition of HERG1 K⁺ channels by the novel second‐generation antihistamine mizolastine

2000 • 37 citations

Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity

1994 • 36 citations

Effects of anti-allergic drugs on human neutrophil superoxide-generating NADPH oxidase

1992 • 36 citations

Topical ocular levocabastine reduces ICAM‐1 expression on epithelial cells both in vivo and in vitro

1996 • 34 citations

Dual Effect of the Anti-Allergic Astemizole on Ca2 Fluxes in Rat Basophilic Leukemia (RBL-2H3) Cells: Release of Ca2 from Intracellular Stores and Inhibition of Ca2 Release-Activated Ca2 Influx

1998 • 31 citations

Levocabastine versus cromolyn sodium in the treatment of pollen-induced conjunctivitis.

1990 • 28 citations

The effect of cetirizine and loratadine on codeine-induced histamine release in human skin in vivo assessed by cutaneous microdialysis

1996 • 22 citations

Loratadine reduces the expression of ICAM‐1

1998 • 20 citations

Leukotriene B4 induced steady state calcium rise and superoxide anion generation in guinea pig eosinophils are not related events

1992 • 19 citations

Effect of calmodulin inhibitors on histamine secretion from mast cells

1985 • 19 citations

Mechanisms of mediator release from human skin mast cells upon stimulation by the bradykinin analog, [dArg0-Hyp3-dPhe7]bradykinin

1991 • 19 citations

Reduction of soluble ICAM‐1 levels in nasal secretion by H₁‐blockers in seasonal allergic rhinitis

1997 • 19 citations

Effects of H_1-and H_2-antihistamines on platelet-activating factor and bradykinin-induced inflammatory responses in human skin

1996 • 18 citations

Inhibition of chemiluminescence in granulocytes and alveolar macrophages by azelastine

1990 • 18 citations

Effects of the anti-allergics astemizole and norastemizole on FcεRI receptor-mediated signal transduction processes

1997 • 15 citations

Action of azelastine on intracellular Ca2+ in cultured airway smooth muscle

1991 • 15 citations

Hypothetical Mechanisms of Action of an H1–Antihistamine in Asthma

1999 • 14 citations

Effects of selective histamine receptor antagonists on skin responses to intradermal bradykinin in healthy volunteers

1992 • 14 citations

Methacholine induces wheal‐and‐flare reactions in human skin but does not release histamine in vivo as assessed by the skin microdialysis technique

1995 • 13 citations

Studies into the Mechanisms of Dermal Inflammation Using Cutaneous Microdialysis

1997 • 13 citations

Structure–activity relationships of astemizole derivatives for inhibition of store operated Ca2+ channels and exocytosis

1998 • 12 citations

Divalent cation dependence of the inhibition by phenothiazines of mediator release from mast cells

1989 • 10 citations

Short communication. Cetirizine inhibits bradykinin‐induced cutaneous wheal and flare in atopic and healthy subjects

2000 • 10 citations

The stimuli releasing histamine from murine bone marrow-derived mast cells. 1. The presence of P2-purinoceptors.

1989 • 5 citations

[Biochemical study on anti-inflammatory action of anti-allergic drugs--with regard to NADPH oxidase].

1991 • 4 citations