Effects of the anti-allergics astemizole and norastemizole on FcεRI receptor-mediated signal transduction processes

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Capacitative calcium entry

1995 • 1,112 citations

Calcium release‐activated calcium current in rat mast cells.

1993 • 729 citations

The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells

1993 • 445 citations

Signal transduction by Fc receptors: the Fc&RI case

1993 • 373 citations

Differential control of the tyrosine kinases Lyn and Syk by the two signaling chains of the high affinity immunoglobulin E receptor.

1994 • 367 citations

Transmembrane signaling: the joy of aggregation.

1992 • 267 citations

Astemizole

1984 • 258 citations

Differential Interaction with and Regulation of Multiple G-proteins by the Rat A3 Adenosine Receptor

1995 • 136 citations

Inhibition of Ca2+ transport pathways in thymic lymphocytes by econazole, miconazole, and SKF 96365

1993 • 133 citations

Interfacial ionization and partitioning of membrane-bound local anaesthetics

1992 • 99 citations

In vitro and in vivo binding characteristics of a new long-acting histamine H1 antagonist, astemizole.

1982 • 97 citations

Adherence of rat basophilic leukemia (RBL-2H3) cells to fibronectin-coated surfaces enhances secretion.

1992 • 94 citations

Expression and function of fibronectin binding integrins on rat mast cells

1995 • 90 citations

High-affinity IgE receptor-mediated stimulation of rat basophilic leukemia (RBL-2H3) cells induces early and late protein-tyrosine phosphorylations.

1992 • 88 citations

The antiallergic effects of antihistamines (H-receptor antagonists)

1992 • 87 citations

TRP Is Cracked but Is CRAC TRP?

1996 • 82 citations

Activation of protein tyrosine kinase p72syk by Fc epsilon RI aggregation in rat basophilic leukemia cells. p72syk is a minor component but the major protein tyrosine kinase of pp72

1994 • 70 citations

Antigen and thapsigargin promote influx of Ca2+ in rat basophilic RBL-2H3 cells by ostensibly similar mechanisms that allow filling of inositol 1,4,5-trisphosphate-sensitive and mitochondrial Ca2+ stores

1994 • 67 citations

Cell adherence to fibronectin and the aggregation of the high affinity immunoglobulin E receptor synergistically regulate tyrosine phosphorylation of 105-115-kDa proteins.

1993 • 64 citations

Stimulation of mitogen-activated protein kinase activity by different secretory stimuli in rat basophilic leukemia cells.

1994 • 61 citations

Histamine and asthma: an appraisal based on specific H₁‐receptor antagonism

1990 • 50 citations

Pharmacology of the specific histamine H1-antagonist astemizole.

1983 • 46 citations

Phospholipase C-gamma 1 is translocated to the membrane of rat basophilic leukemia cells in response to aggregation of IgE receptors.

1992 • 45 citations

An improved colloidal silver staining method of protein blots on nitrocellulose membranes.

1987 • 43 citations

The High-Affinity Receptor for Immunoglobulin E

2015 • 40 citations

Initial events in FcϵRI signal transduction

1994 • 33 citations

Inhibition of mediator release in RBL-2H3 cells by some H1-antagonist derived anti-allergic drugs: Relation to lipophilicity and membrane effects

1995 • 30 citations

Alteration of Lipid Composition Modulates Fc.epsilon.RI Signaling in RBL-2H3 Cells

1995 • 21 citations

The pharmacological profile of a specific, safe, effective and non-sedative anti-allergic, astemizole

1986 • 20 citations

Effects of antihistamines on isolated rat peritoneal mast cells and on model membrane systems

1990 • 19 citations

Antiallergic effects of major metabolites of astemizole in rats and guinea pigs.

1991 • 16 citations

Mast cells and their microenvironment: the influence of fibronectin and fibroblasts on the functional repertoire of rat basophilic leukemia cells.

1993 • 15 citations

The High-Affinity Receptor for Immunoglobulin E

1994 • 12 citations

Effect of astemizole on antigen‐mediated histamine release from the blood of patients with allergic rhinitis

1992 • 11 citations

Oxatomide and derivatives as inhibitors of mediator release from a mast cell model. Structure-activity relationships.

1996 • 10 citations

Antiallergic effects of astemizole on immediate type hypersensitivity reactions.

1990 • 9 citations

Effects of antihistamines on isolated human lung mast cells, basophil leucocytes and erythrocytes

1989 • 9 citations

Influence of the anti-allergic drug oxatomide on the signal transduction mechanism in a mast cell model

1996 • 8 citations

[16] Phospholipase C activity in Dictyostelium discoideum using endogenous nonradioactive phosphatidylinositol 4,5-bisphosphate as substrate

1994 • 6 citations

Uptake, subcellular distribution and biotransformation of 3H-labelled astemizole in cultured rat hepatocytes

1987 • 4 citations