New Insights into the Second Generation Antihistamines

Aviat space environ med

1992 • 7,493 citations

Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC

1998 • 3,347 citations

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

1995 • 2,391 citations

Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee.

1998 • 1,813 citations

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.

1990 • 1,467 citations

A family of potassium channel genes related to eag in Drosophila and mammals.

1994 • 960 citations

H1-Receptor Antagonists

1994 • 757 citations

Consensus statement * on the treatment of allergic rhinitis

2000 • 661 citations

Terfenadine-Ketoconazole Interaction

1993 • 654 citations

Mechanism of the Cardiotoxic Actions of Terfenadine

1993 • 627 citations

Advances in Drug Research

1964 • 615 citations

Intranasal corticosteroids versus oral H1 receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials

1998 • 529 citations

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

1988 • 514 citations

Hydrophobicity and Central Nervous System Agents: On the Principle of Minimal Hydrophobicity in Drug Design

1987 • 418 citations

Molecular pharmacological aspects of histamine receptors

1995 • 353 citations

Seasonal allergic rhinitis and antihistamine effects on children's learning

1992 • 330 citations

HERG, a Primary Human Ventricular Target of the Nonsedating Antihistamine Terfenadine

1996 • 294 citations

Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel: Lack of prediction by the erythromycin breath test

1994 • 291 citations

Assessment of quality of life in patients with perennial allergic rhinitis with the French version of the SF-36 Health Status Questionnaire

1994 • 271 citations

herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells?

1998 • 261 citations

Cardiac Actions of Antihistamines

1996 • 261 citations

Second-Generation Antihistamines

1999 • 238 citations

Expression cloning of a cDNA encoding the bovine histamine H1 receptor.

1991 • 230 citations

Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole

1996 • 227 citations

Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with methacholine bronchial hyperresponsiveness.

1987 • 221 citations

Cardiac Electrophysiological Actions of the Histamine H₁-Receptor Antagonists Astemizole and Terfenadine Compared With Chlorpheniramine and Pyrilamine

1995 • 214 citations

Cetirizine

1993 • 214 citations

Allergic factors associated with the development of asthma and the influence of cetirizine in a double‐blind, randomised, placebo‐controlled trial: First results of ETA®

1998 • 212 citations

Effect of cetirizine on mast cell-mediator release and cellular traffic during the cutaneous late-phase reaction

1989 • 209 citations

Inhibitory effect of cetirizine 2HCl on eosinophil migration in vivo

1987 • 199 citations

Cetirizine in patients with seasonal rhinitis and concomitant asthma: prospective, randomized, placebo-controlled trial

1995 • 188 citations

Effects of loratadine and cetirizine on actual driving and psychometric test performance, and EEG during driving

1992 • 178 citations

Efficacy and safety of loratadine plus pseudoephedrine in patients with seasonal allergic rhinitis and mild asthma

1997 • 172 citations

Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis☆☆☆

1999 • 168 citations

Cardiotoxic effect with convulsions in terfenadine overdose.

1989 • 168 citations

Direct evidence of a role for mast cells in the pathogenesis of antigen-induced bronchoconstriction.

1987 • 164 citations

Antihistamine effects on actual driving performance in a standard test: a summary of Dutch experience, 1989‐94

1995 • 161 citations

A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: Suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects

1990 • 160 citations

Pharmacokinetics and pharmacodynamics of terfenadine and chlorpheniramine in the elderly

1990 • 159 citations

A double-blind, placebo-controlled trial of fexofenadine HCl in the treatment of chronic idiopathic urticaria☆☆☆★

1999 • 153 citations

Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin

1988 • 147 citations

Sedative effects of antihistamines

1987 • 147 citations

Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side‐effects

1999 • 146 citations

Pharmacological considerations in the modulation of multidrug resistance

1996 • 139 citations

Effects of terfenadine and its metabolites on a delayed rectifier K+ channel cloned from human heart.

1993 • 136 citations

Cetirizine reduces inflammatory cell recruitment and ICAM-1 (or CD54) expression on conjunctival epithelium in both early- and late-phase reactions after allergen-specific challenge

1995 • 136 citations

Molecular Basis for the Lack of HERG K⁺Channel Block-Related Cardiotoxicity by the H₁Receptor Blocker Cetirizine Compared with Other Second-Generation Antihistamines

1998 • 133 citations

Molecular Properties and Pharmacokinetic Behavior of Cetirizine, a Zwitterionic H₁-Receptor Antagonist

1998 • 129 citations

Chronic urticaria serum induces histamine release, leukotriene production, and basophil CD63 surface expression—Inhibitory effects of anti-inflammatory drugs

2000 • 127 citations

Allergic subjects express intercellular adhesion molecule — 1 (ICAMA or CD54) on epithelial cells of conjunctiva after allergen challenge

1993 • 125 citations

Prospective, long-term safety evaluation of the H1-receptor antagonist cetirizine in very young children with atopic dermatitis☆☆☆★★★

1999 • 120 citations

Sedation and histamine H₁‐receptor antagonism: studies in man with the enantiomers of chlorpheniramine and dimethindene

1991 • 118 citations

Sedation and antihistamines: a review of inter-drug differences using proportional impairment ratios

2000 • 117 citations

Reversal of multidrug resistance by phenothiazines and structurally related compounds

1992 • 114 citations

Improvement of quality of life by treatment with cetirizine in patients with perennial allergic rhinitis as determined by a French version of the SF-36 questionnaire

1996 • 112 citations

Effect of fexofenadine on eosinophil-induced changes in epithelial permeability and cytokine release from nasal epithelial cells of patients with seasonal allergic rhinitis☆☆☆★★★

1998 • 109 citations

Time-dependent outward current in guinea pig ventricular myocytes. Gating kinetics of the delayed rectifier.

1990 • 108 citations

Topical azelastine reduces eosinophil activation and intercellular adhesion molecule-1 expression on nasal epithelial cells: An antiallergic activity☆☆☆★★★

1996 • 108 citations

Epidemiological evidence of the occurrence of rhinitis and sinusitis in asthmatics

1999 • 108 citations

A double‐blind, single‐dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine‐induced wheal and flare response for 24 h in healthy male subjects

1999 • 108 citations

Fexofenadine

1998 • 107 citations

Antiallergic activity of H-receptor antagonists assessed by nasal challenge

1988 • 106 citations

The relative antihistaminic and psychomotor effects of hydroxyzine and cetirizine

1987 • 104 citations

Lipophilicity and hydrogen-bonding capacity of H1-antihistaminic agents in relation to their central sedative side-effects

1994 • 103 citations

Urticaria: Clinical efficacy of cetirizine in comparison with hydroxyzine and placebo

1990 • 100 citations

The metabolism and pharmacokinetics of 14C-cetirizine in humans.

1987 • 100 citations

Suppression of TNF-alpha secretion by azelastine in a rat mast (RBL-2H3) cell line: evidence for differential regulation of TNF-alpha release, transcription, and degranulation.

1997 • 98 citations

A double‐blind, placebo‐controlled investigation of the effects of fexofenadine, loratadine and promethazine on cognitive and psychomotor function

1999 • 97 citations

Inhibitory effect of cetirizine on the bronchial eosinophil recruitment induced by allergen inhalation challenge in allergic patients with asthma

1992 • 97 citations

Terfenadine, an H₁Antihistamine, Inhibits Histamine ReleaseIn Vivoin the Human

1990 • 96 citations

Comparison of the Effect of the Macrolide Antibiotics Erythromycin, Clarithromycin and Azithromycin on Terfenadine Steady-State Pharmacokinetics and Electrocardiographic Parameters

1994 • 93 citations

H1-receptor antagonists: safety issues

1999 • 92 citations

In vivo occupation of cerebral histamine H1-receptors evaluated with 3H-mepyramine may predict sedative properties of psychotropic drugs

1979 • 92 citations

Effects of allergy season on mood and cognitive function.

1993 • 92 citations

Double-blind comparison of cetirizine and placebo in the treatment of seasonal rhinitis.

1991 • 91 citations

Histaminergic systems and sleep

1985 • 89 citations

Non‐H₁‐receptor effects of antihistamines

1999 • 87 citations

Onset of Action, Efficacy, and Safety of a Single Dose of Fexofenadine Hydrochloride for Ragweed Allergy Using an Environmental Exposure Unit

1997 • 87 citations

Comparison of the bronchodilatory effects of cetirizine, albuterol, and both together versus placebo in patients with mild-to-moderate asthma

1995 • 86 citations

Cetirizine Reduces ICAM-I on Epithelial Cells during Nasal Minimal Persistent Inflammation in Asymptomatic Children with Mite-Allergic Asthma

1996 • 85 citations

Antihistamines in asthma

1989 • 85 citations

The pharmacology and mechanisms of action of histamine H₁‐antagonists

1990 • 85 citations

Histamine receptors: subclasses and specific ligands

1990 • 84 citations

Advances in the Immunobiology of Eosinophils and Their Role in Disease

1999 • 84 citations

Inhibition of Eosinophil Chemotaxis by a New Antiallergic Compound (Cetirizine)

1988 • 82 citations

Loratadine: a non‐sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation

1999 • 82 citations

Cetirizine: A pharmacokinetic and pharmacodynamic evaluation in children with seasonal allergic rhinitis

1989 • 81 citations

Effect of H1 receptor blockade on the early and late response to cutaneous allergen challenge.

1992 • 79 citations

Sedation in allergic rhinitis is caused by the condition and not by antihistamine treatment

1996 • 75 citations

Comparative analysis of the cardiotoxicity proclivities of second generation antihistamines in an experimental model predictive of adverse clinical ECG effects.

1996 • 75 citations

Sleepiness and performance during three-day administration of cetirizine or diphenhydramine

1994 • 75 citations

Treatment of bronchial asthma with terfenadine; a randomized controlled trial.

1987 • 75 citations

Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamine

1986 • 74 citations

The clinical safety of H₁‐receptor antagonists: An EAACI position paper*

1996 • 74 citations

The metabolism of antihistamines and drug interactions: the role of cytochrome P450 enzymes

1999 • 72 citations

The electrocardiographic effects of cetirizine in normal subjects

1994 • 71 citations

Consensus statement on the treatment of allergic rhinitis (European Academy of Allergology and Clinical Immunology)

2001 • 71 citations

Suppression by Azelastine Hydrochloride of NF-/.KAPPA.B Activation Involved in Generation of Cytokines and Nitric Oxide.

1997 • 71 citations

Continuous Versus On Demand Treatment with Cetirizine for Allergic Rhinitis

1997 • 71 citations

Quantitative effects of cetirizine and diphenhydramine on mental performance measured using an automobile driving simulator.

1990 • 71 citations

Antihistamines: Impaired performance and the tendency to sleep

1986 • 71 citations

Loratadine administered concomitantly with erythromycin: Pharmacokinetic and electrocardiographic evaluations*

1995 • 71 citations

Mechanisms of human eosinophil survival and apoptosis

1997 • 70 citations

In vitro effects of H₁‐antihistamines on histamine and PGD₂ release from mast cells of human lung, tonsil, and skin

1994 • 70 citations

Inhibition of Human Eosinophil Chemotaxis and of the IgE-Dependent Stimulation of Human Blood Platelets by Cetirizine

1989 • 69 citations

Allergen-induced increase in nonspecific nasal reactivity is blocked by antihistamines without a clear-cut relationship to eosinophil influx

1990 • 69 citations

Azelastine eye drops reduce and prevent allergic conjunctival reaction and exert anti‐allergic activity

1997 • 69 citations

Terfenadine and Fexofenadine Reduce in Vitro ICAM-1 Expression on Human Continuous Cell Lines

1998 • 68 citations

Comparative safety of H1 antihistamines.

1991 • 67 citations

Are antihistamines sedative via a blockade of brain H1 receptors?

1979 • 66 citations

Cetirizine effects on objective measures of daytime sleepiness and performance.

1987 • 66 citations

Terfenadine, a potent histamine H1‐receptor antagonist in the treatment of grass pollen sensitive asthma.

1990 • 66 citations

Evaluation of Cetirizine in Patients with Allergic Rhinitis and Perennial Asthma

1996 • 65 citations

In vivo effects of cetirizine on cutaneous reactivity and eosinophil migration induced by platelet-activating factor (PAF-acether) in man

1990 • 65 citations

Efficacy and safety of cetirizine therapy in perennial allergic rhinitis.

1992 • 64 citations

Does cetirizine belong to the new generation of antihistamines? An investigation into its acute and subchronic effects on highway driving, psychometric test performance and daytime sleepiness

1992 • 64 citations

The comparative actions and adverse effect profile of single doses of H-receptor antihistamines in the airways and skin of subjects with asthma

1993 • 64 citations

Inhibitory activity of loratadine and descarboxyethoxyloratadine on histamine‐induced activation of endothelial cells

1997 • 63 citations

Antihistamines, drowsiness, and psychomotor impairment: central nervous system effect of cetirizine.

1987 • 62 citations

Cetirizine counter‐regulates interleukin‐8 release from human epithelial cells (A549)

1999 • 61 citations

Terfenadine exerts antiallergic activity reducing ICAM‐1 expression on nasal epithelial cells in patients with pollen allergy

1995 • 60 citations

Block of human cardiac Kv1.5 channels by loratadine: voltage-, time- and use-dependent block at concentrations above therapeutic levels

1997 • 60 citations

Comparison of the central nervous system effects produce by six H₁‐receptor antagonists

1996 • 60 citations

The systemic safety of fexofenadine HCl

1999 • 59 citations

The inhibitory effects of boldine, glaucine, and probucol on TPA-induced down regulation of gap junction function

1995 • 57 citations

A placebo‐controlled trial of cetirizine in seasonal allergic rhino‐conjunctivitis in children aged 6 to 12 years

1993 • 57 citations

Loratadine treatment of rhinitis due to pollen allergy reduces epithelial ICAM‐1 expression

1997 • 57 citations

Peripheral H1-Blockade Effect of Fexofenadine

1997 • 56 citations

Comparative Tolerability of Second Generation Antihistamines

1999 • 55 citations

Variations among non-sedating antihistamines: are there real differences?

1999 • 54 citations

Prophylactic treatment of grass pollen‐induced asthma with cetirizine

1990 • 54 citations

Terfenadine (seldane®): A new drug for restoring sensitivity to multidrug resistant cancer cells

1993 • 53 citations

Spontaneous histamine release and histamine content in normal subjects and subjects with asthma

1989 • 53 citations

Effects of cetirizine on the delayed K⁺ currents in cardiac cells: comparison with terfenadine

1998 • 52 citations

Cetirizine inhibits the in vitro and ex vivo chemotactic response of T lymphocytes and monocytes

1995 • 52 citations

Cetirizine treatment of rhinitis in children with pollen allergy: evidence of its antiallergic activity

1997 • 52 citations

Effect of loratadine on nitrogen dioxide–induced changes in electrical resistance and release of inflammatory mediators from cultured human bronchial epithelial cells☆☆☆★

1999 • 52 citations

Protective effect of cetirizine in patients suffering from pollen asthma.

1990 • 51 citations

The comparative pharmacokinetics of H1-receptor antagonists.

1987 • 50 citations

Protective Effect of Loratadine on Late Phase Reaction Induced by Conjunctival Provocation Test

1993 • 50 citations

Comparative Study of Cetirizine and Terfenadine Versus Placebo in the Symptomatic Management of Seasonal Allergic Rhinitis

1996 • 49 citations

Lack of interaction between two antihistamines, mizolastine and cetirizine, and ethanol in psychomotor and driving performance in healthy subjects

1995 • 48 citations

Loratadine, and antihistamine, blocks antigen- and ionophore- induced leukotriene release from human lung in vitro

1988 • 48 citations

Inhibition of Leukotriene (SRS‐A)‐Mediated Acute Lung Anaphylaxis by Azelastine in Guinea Pigs

1986 • 47 citations

Model for outcomes assessment of antihistamine use for seasonal allergic rhinitis

1996 • 47 citations

Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes.

1996 • 46 citations

Evaluation of the Potential Cardiotoxicity of the Antihistamines Terfenadine, Astemizole, Loratadine, and Cetirizine in Atopic Children

1998 • 46 citations

Antihistamines and aircrew: usefulness of fexofenadine.

2000 • 45 citations

Corticosteroid-sparing effect of azelastine in the management of bronchial asthma.

1996 • 45 citations

Effects of Some Anti-Asthma Drugs on Human Eosinophil Superoxide Anions Release and Degranulation

1998 • 44 citations

Is there a difference in the affinity of histamine H1 receptor antagonists for CNS and peripheral receptors? An in vitro study

1993 • 44 citations

Double-blind multicenter study of cetirizine in grass-pollen-induced asthma.

1990 • 43 citations

Inhibition of IgE- and non-IgE-mediated histamine release from human basophil leukocytes in vitro by a histamine H1-antagonist, desethoxycarbonyl-loratadine

1994 • 43 citations

The effects of terfenadine with and without alcohol on an aspect of car driving performance

1989 • 43 citations

Effects of various drugs on superoxide generation, arachidonic acid release and phospholipase A2 in polymorphonuclear leukocytes.

1988 • 43 citations

Peripheral antihistamine and central sedative effects of single and continuous oral doses of cetirizine and hydroxyzine

1991 • 42 citations

Inhibition of mediator and cytokine release from dispersed nasal polyp cells by mizolastine

2002 • 42 citations

Psychometric aspects of antihistamines

1995 • 41 citations

Pharmacokinetic-Pharmacodynamic Relationships of H1-Antihistamines

1995 • 41 citations

Antihistamines in the treatment of asthma

1997 • 41 citations

Overview of Allergic Mechanisms

1996 • 40 citations

Effect of loratadine on human eosinophil function in vitro.

1993 • 40 citations

Effect of cetirizine, a new H antihistamine, on the early and late allergic reactions in a bronchial provocation test with allergen

1993 • 40 citations

Inhibition of Leukotriene Synthesis by Azelastine

1996 • 40 citations

Central effects of the H1-antihistamine, cetirizine.

1998 • 39 citations

Suppresive effect of loratadine on allergen‐induced histamine release in the nose

1991 • 39 citations

Effects of Cetirizine on Human Eosinophil and Neutrophil Activation in vitro

1991 • 39 citations

Effect of cetirizine and prednisolone on cellular infiltration and cytokine mRNA expression during allergen‐induced late cutaneous responses

1996 • 38 citations

The effect of a single oral dose of prednisolone or cetirizine on inflammatory cells infiltrating allergen‐induced cutaneous late‐phase reactions in atopic subjects

1992 • 38 citations

Anti-inflammatory properties of mizolastine after oral administration on arachidonic acid-induced cutaneous reaction in the rat.

1998 • 38 citations

Cetirizine treatment of allergic cough in children with pollen allergy

1997 • 38 citations

Cellular inflammatory responses during immediate, developing, and established late-phase allergic cutaneous reactions: Effects of cetirizine

1997 • 37 citations

Histamine and H1-receptor antagonists in allergic disease

1996 • 37 citations

Direct measurement of daytime sleepiness after administration of cetirizine and hydroxyzine with a standardized electroencephalographic assessment

1990 • 37 citations

Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity

1994 • 36 citations

Effects of anti-allergic drugs on human neutrophil superoxide-generating NADPH oxidase

1992 • 36 citations

Protective effect of different doses of terfenadine on the conjunctival provocation test

1992 • 35 citations

The anti‐inflammatory effects of cetirizine

1994 • 35 citations

Modulation of human eosinophil chemotaxis and adhesion by anti‐allergic drugs in vitro

1993 • 35 citations

A comparison of the effects of oral cetirizine and inhaled beclomethasone on early and late asthmatic responses to allergen and the associated increase in airways hyperresponsiveness

1996 • 34 citations

Loratadine reduces allergen-induced mucosal output of α-macroglobulin and tryptase in allergic rhinitis

1995 • 34 citations

A controlled study on the effectiveness of loratadine in combination with flunisolide in the treatment of nonallergic rhinitis with eosinophilia (NARES)

1999 • 33 citations

Effects of Anti-Allergic Drugs on Substance P (SP) and Vasoactive Intestinal Peptide (VIP) in Nasal Secretions

1997 • 33 citations

Effect of Cetirizine on Human Eosinophil Superoxide Generation, Eosinophil Chemotaxis and Eosinophil Peroxidase in vitro

1994 • 33 citations

Specific review of the psychometric effects of cetirizine

1995 • 32 citations

Lack of potentiation by cetirizine of alcohol ? Induced psychomotor disturbances

1988 • 32 citations

A comparison of the efficacy of Cetirizine and terfenadine

1993 • 32 citations

Cetirizine vs Astemizole in the Treatment of Chronic Idiopathic Urticaria

1990 • 32 citations

Effect of a non‐sedative antihistaminic (loratadine) in moderate asthma

1989 • 32 citations

Clinical assessment of antihistamines in rhinitis

1999 • 31 citations

Leukotriene B₄ production by blood neutrophils in allergic rhinitis—effects of cetirizine

1995 • 31 citations

H1-receptor antagonist treatment of seasonal allergic rhinitis

1990 • 31 citations

Allergic factors associated with the development of asthma and the influence of cetirizine in a double-blind, randomised, placebo-controlled trial: first results of ETAC. Early Treatment of the Atopic Child.

1998 • 31 citations

Consistency of the Efficacy of Cetirizine and Ebastine on Skin Reactivity

1998 • 30 citations

Evaluation of loratadine as an inducer of liver microsomal cytochrome P450 in rats and mice

1992 • 30 citations

Perennial allergic rhinitis: Clinical efficacy of a new antihistamine

1990 • 30 citations

Histamine and tryptase in nasal lavage fluid after allergen challenge: Effect of 1 week of pretreatment with intranasal azelastine or systemic cetirizine

1999 • 30 citations

Pharmacological Modulation by Cetirizine and Loratadine of Antigen and Histamine-Induced Skin Weals and Flares, and Late Accumulation of Eosinophils

1990 • 29 citations

Characterization of a primate model of asthma using anti-allergy/ anti-asthma agents

1996 • 29 citations

Comparison of cetirizine and terfenadine in the treatment of chronic idiopathic urticaria.

1990 • 28 citations

Effect of mizolastine on visceral sensory afferent sensitivity and inflammation during experimental colitis.

1998 • 27 citations

Effects of loratadine on anti‐IgE‐induced inflammation, histamine release, and leukocyte recruitment in skin of atopics

1995 • 27 citations

QT interval monitoring during clinical studies with mizolastine, a new H₁ antihistamine

1999 • 25 citations

Dose-response relationship of the H1-histamine antagonist, ebastine, against histamine and methacholine-induced bronchoconstriction in patients with asthma

1990 • 25 citations

Loratedine and ventricular tachycardia

1994 • 24 citations

Platelet aggregation and histamine release by immunological stimuli

1994 • 24 citations

The effects of cetirizine on the function of inflammatory cells involved in the allergic response

1997 • 24 citations

Effects of azelastine on the level of serum interleukin-4 and soluble CD23 antigen in the treatment of nasal allergy.

1998 • 23 citations

Azelastine and flezelastine as reversing agents of multidrug resistance: Pharmacological and molecular studies

1995 • 23 citations

Cetirizine vs placebo in chronic idiopathic urticaria--a double blind randomised cross-over study.

1991 • 23 citations

Effects of antihistamines on cutaneous reactions and influx of eosinophils after local injection of PAF, kallikrein, compound 48/80 and histamine in patients with chronic urticaria and healthy subjects.

1992 • 23 citations

Effect of terfenadine on human eosinophil and neutrophil chemotactic response and generation of superoxide.

1994 • 23 citations

Oxatomide reduces inflammatory events induced by allergen-specific conjunctival challenge.

1995 • 23 citations

Effects of antihistamines on inflammatory mediators.

1993 • 23 citations

Inhibition of histamine‐induced nasal obstruction by cetirizine in allergic rhinitis.

1992 • 23 citations

Cellular inflammatory responses and mediator release during early developing late-phase allergic cutaneous inflammatory responses: Effects of cetirizine

1997 • 23 citations

Inhibition of mediator and cytokine release from dispersed nasal polyp cells by terfenadine

1996 • 22 citations

The effect of cetirizine and loratadine on codeine-induced histamine release in human skin in vivo assessed by cutaneous microdialysis

1996 • 22 citations

Cetirizine Exerts Anti-Inflammatory Effects on Human Neutrophils

1996 • 22 citations

Lack of effect of loratadine on moderate to severe asthma.

1995 • 21 citations

Efficacy of cetirizine in the treatment of seasonal allergic rhinoconjunctivitis.

1990 • 21 citations

Investigation of the anti‐allergic activity of azelastine on the immediate and late‐phase reactions to allergens and histamine using telethermography

2000 • 21 citations

Multicenter, crossover study of the efficacy and tolerability of terfenadine, 120 mg, versus cetirizine, 10 mg, in perennial allergic rhinitis.

1991 • 21 citations

Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.

1998 • 21 citations

PHARMACOLOGIC MODULATION BY CETIRIZINE OF SOME ADHESION MOLECULES EXPRESSION IN PSORIATIC SKIN LESIONS

1995 • 20 citations

Loratadine reduces the expression of ICAM‐1

1998 • 20 citations

Effect of cetirizine on cutaneous reactions to PAF, kallikrein and serum in patients with chronic urticaria.

1990 • 20 citations

Is there a place for antihistamines in the treatment of perennial asthma?

1993 • 20 citations

Survey of recognition and utilization of guidelines for the diagnosis and management of bronchial asthma in Japan

2000 • 19 citations

The effect of cetirizine on sulfidoleukotriene production by blood leukocytes in children with allergic rhinitis

1995 • 19 citations

Reduction of soluble ICAM‐1 levels in nasal secretion by H₁‐blockers in seasonal allergic rhinitis

1997 • 19 citations

The impact of allergic rhinitis on quality of life and other airway diseases

1998 • 19 citations

Hypertension during reduction of long-term steroid therapy in young subjects with asthma

1992 • 19 citations

Dose-ranging comparative evaluation of cetirizine in patients with seasonal allergic rhinitis.

1995 • 18 citations

In vitro effect of cetirizine on PGE2 release by rat peritoneal macrophages and human monocytes

1994 • 18 citations

Quantitative flow cytometric analysis of the effects of cetirizine on the expression of ICAM‐1/CD54 on primary cultured nasal cells

2000 • 18 citations

Comparison of efficacy, safety, and skin test inhibition of cetirizine and astemizole

1996 • 17 citations

Differential IL-10 receptor gene expression in acute versus chronic atopic eczema. Modulation by immunosuppressive drugs and cytokines in normal cultured keratinocytes

1999 • 17 citations

CanineIn VivoTracheal Chemotaxis of Eosinophils to Antigen in Sensitized Dogs: Inhibition by a Steroid, a Systemic Lazaroid U-78517F, and Several Topical H₁Antihistamines

1992 • 17 citations

Inhibitory Effect of Epinastine on Superoxide Generation by Rat Neutrophils

1995 • 17 citations

Cetirizine inhibits bradykinin‐induced cutaneous wheal and flare in atopic and healthy subjects

2000 • 16 citations

Pharmacologic modulation by cetirizine 2 HCl and loratadine of the histamine‐induced skin reaction in mice and in humans

1989 • 16 citations

Loratadine Produces Antihistamine Activity without Adverse CNS, ECG or Cardiovascular Effects in Guinea Pigs

1995 • 16 citations

Antiallergic effects of major metabolites of astemizole in rats and guinea pigs.

1991 • 16 citations

Effect of ebastine on mosquito bites.

1997 • 16 citations

Effect of azelastine on platelet-activating factor-induced microvascular leakage in rat airways

1999 • 16 citations

A Comparison of Cetirizine, Ebastine, Epinastine, Fexofenadine, Terfenadine, and Loratadine versus Placebo in Suppressing the Cutaneous Response to Histamine

1999 • 15 citations

Influence of the anti-allergic agent, azelastine, on tumor necrosis factor-alpha (TNF-alpha) secretion from cultured mouse mast cells.

1998 • 15 citations

31 Evaluation of cetirizine in the treatment of patients with seasonal allergic rhinitis

1988 • 15 citations

Cutaneous IgE‐mediated inflammatory lesion size is inhibited by an H₁ antagonist (terfenadine) while mediator release is unaffected in vivo and in vitro

1993 • 15 citations

Prophylactic treatment of seasonal allergic rhinitis.

1991 • 15 citations

Inhibitory effects of azelastine on superoxide anion generation from activated inflammatory cells measured by a simple chemiluminescence method.

1990 • 13 citations

An evaluation of the efficacy and safety of azelastine in patients with chronic asthma

1996 • 13 citations

The effects of a new generation of H1 antihistamines (cetirizine and loratadine) on histamine release and the bronchial response to histamine in atopic patients.

1995 • 13 citations

A Clinical Comparison of Cetirizine Versus Astemizole in Perennial Allergic Rhinitis

1993 • 13 citations

Effects of Azelastine on Neutrophil Chemotaxis, Phagocytosis and Oxygen Radical Generation.

1991 • 13 citations

A study of the Interaction Between Cetirizine and Plasma Membrane ofEosinophils, Neutrophils, Platelets and Lymphocytes using A fluorescence Technique

1994 • 13 citations

Evaluation of the effect of oral cetirizine on antigen-induced immediate asthmatic response.

1990 • 13 citations

In vivo binding properties of non‐sedating antihistamines to CNS histamine receptors

1990 • 13 citations

Additional Properties of Cetirizine, a New H₁ Antagonist

1991 • 12 citations

[Allergic bronchial asthma treated with Loratadine].

1993 • 12 citations

Effect of cetirizine, a potent H₁ antagonist, on platelet activating factor induced bronchoconstriction in asthma

1993 • 12 citations

Assessment of the Wheal Size and Skin Blood Flow of the Erythema Induced by Histamine and Its Modification with Cetirizine and Ebastine: A Crossover, Double-Blind Study

1994 • 12 citations

Suppression by cetirizine of pleurisy triggered by antigen in actively sensitized rats

1992 • 12 citations

Humoral and cellular responses to histamine and pollen allergen in a skin chamber model: effect of mizolastine

2000 • 10 citations

191 Inhibitory effect of rupatadine on TNF-alpha release from human monocytes and mast cell lime HMC-1

2000 • 10 citations

Effect of oral and inhaled cetirizine in allergen induced bronchoconstriction

1993 • 10 citations

Drug Transfer Across the Blood-Brain Barrier: Comparison of in Vitro and in Vivo Models

1993 • 10 citations

49 Anti-inflammatory properties of desloratadine (DCL): Effect on eosinophil chemotaxis, adhesion and release of superoxide anions

2000 • 9 citations

The Effect of Azelastine on the Infiltration of Inflammatory Cells into the Bronchial Mucosa and Clinical Changes in Patients with Bronchial Asthma

1997 • 9 citations

G Proteins as Biological Targets for Anti-Allergic Drugs?

1997 • 8 citations

Drug transport into the central nervous system.

1980 • 8 citations

To use or not to use antihistamines in patients with asthma.

1990 • 8 citations

Pleural fluid eosinophils suppress local IgE-mediated protein exudation in rats

1995 • 8 citations

Azelastine hydrochloride inhibits platelet activating factor-like activity in human eosinophils

1996 • 7 citations

The effect of loratadine on activated cells of the nasal mucosa in patients with allergic rhinitis.

1993 • 7 citations

Effects of Mizolastine in vitro on Human Immunocompetent and Airway Cells: Evidence for Safety and Additional Property

2000 • 7 citations

Azelastine eye drops reduce conjunctival hyperresponsiveness to hyperosmolar glucose challenge in children with asymptomatic mite conjunctivitis.

1999 • 7 citations

The clinical expression of allergy in the lungs

1999 • 6 citations

Allergic bronchial eosinophilia: a therapeutic approach for the selection of potential bronchial anti‐inflammatory drugs

1993 • 6 citations

Effect of azelastine hydrochloride on release and production of platelet activating factor in human neutrophils

1997 • 6 citations

The Joints and Muscles

1995 • 5 citations

The effect of H₁ receptor antagonists on peripheral blood mononuclear cells, adenoid cells and primary cell lines

1995 • 5 citations

The effect of a 1-week administration of cetirizine on the chemotaxis and superoxide anion production of neutrophils from healthy volunteers.

1996 • 5 citations

1116 Antiallergic activity of fexofenadine in vitro

2000 • 5 citations

Duration of Action of a Single Dose of Azelastine in Patients with Chronic Asthma

1995 • 5 citations

Effect of azelastie on PGE2 production in fibroblasts in normal skin. the possibility of inhibition of inducible cyclooxygenase by azelastine

1997 • 4 citations

Inhibitory effect of azelastine hydrochloride on synthesis and release of platelet activating factor from human alveolar macrophages

1997 • 4 citations

[The inhibitory effect of oxatomide on oxygen radical products from human eosinophils and an eosinophilic cell line].

1991 • 3 citations

Are the anti-allergic properties of H1-antihistamines of any clinical relevance?

2000 • 2 citations

Modulation of Eosinophilic Chemotaxis with Azelastine and Budesonide in Allergic Patients

1998 • 2 citations

602 Evaluation of cytokines in nasal secretions after nasal antigen challenge

2000 • 2 citations

Bradykinin-lnduced Immediate Skin Reactions and H<sub>1</sub>-Blockade

1995 • 1 citations

Deleted Work

1955 • 0 citations