Structures and Functions of Lysosomal Thiol Proteinases and Their Endogenous Inhibitor

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells: Part 2

1976 • 1,060 citations

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

1982 • 1,024 citations

Proteinases in mammalian cells and tissues

1978 • 701 citations

Proteinases in Mammalian Cells and Tissues

1977 • 537 citations

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

1979 • 466 citations

Cathepsin B1. A lysosomal enzyme that degrades native collagen

1974 • 405 citations

Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates

1980 • 404 citations

Cathepsin L

1977 • 341 citations

Inhibition by Insulin of Valine Turnover in Liver

1970 • 338 citations

Isolation and characterization of E-64, a new thiol protease inhibitor.

1978 • 319 citations

Degradation of myofibrillar proteins by cathepsins B and D

1977 • 285 citations

Effects of food deprivation on protein synthesis and degradation in rat skeletal muscles

1976 • 284 citations

Canine cardiac calcium‐dependent proteases: Resolution of two forms with different requirements for calcium

1980 • 267 citations

Leupeptin, a Protease Inhibitor, Decreases Protein Degradation in Normal and Diseased Muscles

1978 • 267 citations

The Structure of Papain

1971 • 242 citations

Selective control of the degradation of normal and aberrant proteins in Reuber H35 hepatoma cells

1976 • 234 citations

Early events in the biosynthesis of the lysosomal enzyme cathepsin D.

1979 • 233 citations

The force of contraction of the human ciliary muscle during accommodation

1977 • 228 citations

Inhibition of protein degradation in isolated rat hepatocytes

1977 • 214 citations

Origins and metabolism of the intracellular amino acid pools in rat liver and muscle

1967 • 204 citations

Human cathepsin H

1980 • 193 citations

Biosynthesis of a lysosomal enzyme. Partial structure of two transient and functionally distinct NH2-terminal sequences in cathepsin D.

1981 • 188 citations

The Complete Amino Acid Sequence of Papain

1970 • 183 citations

On the substrate specificity of cathepsins B1 and B2 including a new fluorogenic substrate for cathepsin B1

1975 • 172 citations

The specificity of cathepsin B. Hydrolysis of glucagon at the C-terminus by a peptidyldipeptidase mechanism

1978 • 159 citations

ON THE PROTEOLYTIC ENZYMES OF ANIMAL TISSUES

1952 • 153 citations

Thyroid hormones control lysosomal enzyme activities in liver and skeletal muscle

1978 • 150 citations

Protein Turnover in Skeletal Muscle. II. The Effect of Starvation and a Protein-Free Diet on the Synthesis and Catabolism of Skeletal Muscle Proteins in Comparison to Liver

1970 • 147 citations

General characteristics of protein degradation in diabetes and starvation.

1978 • 125 citations

Purification and Properties of a New Cathepsin from Rat Liver1

1978 • 122 citations

PURIFICATION AND PROPERTIES OF BEEF SPLEEN CATHEPSIN B

1957 • 119 citations

Mode of degradation of myofibrillar proteins by an endogenous protease, cathepsin L

1981 • 117 citations

Differential effects of proteinase inhibitors and amines on the lysosomal and non-lysosomal pathways of protein degradation in isolated rat hepatocytes

1980 • 114 citations

NOTICES OF RECENT PUBLICATIONS

1978 • 113 citations

Effects of Glucagon on General Protein Degradation and Synthesis in Perfused Rat Liver

1974 • 111 citations

Effect of microtubular or translational inhibitors on general cell protein degradation. Evidence for a dual catabolic pathway

1977 • 110 citations

The degradation of proparathormone and parathormone by parathyroid and liver cathepsin B.

1979 • 108 citations

Calcium-dependent Golgi-vesicle fusion and cathepsin B in the conversion of proalbumin into albumin in rat liver

1978 • 100 citations

Inhibitions by E-64 Derivatives of Rat Liver Cathepsin B and Cathepsin L In Vitro and In Vivo 1

1980 • 99 citations

Crystallization and Properties of Cathepsin B from Rat Liver

1979 • 98 citations

Bovine spleen cathepsin B1 and collagenolytic cathepsin. A comparative study of the properties of the two enzymes in the degradation of native collagen

1976 • 97 citations

Papain Inhibitions by Optically Active E-64 Analogs

1981 • 96 citations

Thermostable Endogenous Inhibitors of Cathepsins B and H

1979 • 96 citations

Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B

1980 • 95 citations

Rapid inactivation of cathepsin L by Z-Phe-PheCHN2 and Z-Phe-AlaCHN2

1981 • 95 citations

Human cathepsin B. Application of the substrate N-benzyloxycarbonyl-<scp>l</scp>-arginyl-<scp>l</scp>-arginine 2-naphthylamide to a study of the inhibition by leupeptin

1980 • 91 citations

Glucagon: a Protein Catabolic Hormone in the Isolated Perfused Rat Liver

1960 • 89 citations

Osmotic alterations of the lysosomal system during rat liver perfusion: Reversible suppression by insulin and amino acids

1974 • 85 citations

Protein degradation in hepatocyte monolayers. Effects of glucagon, adenosine 3':5'-cyclic monophosphate and insulin

1980 • 81 citations

Purification and Properties of Two Protease Inhibitors from Rat Skin Inhibiting Papain and Other SH-Proteases.

1976 • 76 citations

Separation of a new alpha-N-benzoylarginine-beta-naphthylamide hydrolase from cathepsin B1. Purification, characterization, and properties of both enzymes from rabbit lung.

1978 • 73 citations

Macrophage protein turnover. Evidence for lysosomal participation in basal proteolysis

1979 • 73 citations

Characterization of a thiol proteinase secreted by malignant human breast tumours

1980 • 72 citations

Isolation and characterization of porcine parathyroid cathepsin B.

1979 • 67 citations

Characterisation of Cathepsin B and Collagenolytic Cathepsin from Human Placenta

1978 • 66 citations

Susceptibilities of Various Myofibrillar Proteins to Cathepsin B and Morphological Alteration of Isolated Myofibrils by This Enzyme1

1981 • 63 citations

Inhibition of basal and deprivation-induced proteolysis by leupeptin and pepstatin in perfused rat liver and heart

1979 • 61 citations

Cathepsin B-like enzymes. Subcellular distribution and properties in neoplastic and control cells from human ectocervix.

1981 • 61 citations

Haptoglobin acting as a Natural Inhibitor of Cathepsin B Activity

1967 • 61 citations

Über ein neues Kathepsin. Reinigung aus Rindermilz, Eigenschaften, sowie Vergleich mit Kathepsin B

1967 • 61 citations

Action of cathepsin L on the oxidized B‐chain of bovine insulin

1980 • 60 citations

New proteolytic enzymes in yeast

1981 • 59 citations

Lysosomal Cathepsin B1: Partial Characterization in Rat Preputial Gland and Recompartmentation in Response to Estradiol‐17β

1976 • 58 citations

Isolation and partial characterisation of a thiol proteinase inhibitor from human plasma

1979 • 57 citations

Further purification of a protease inhibitor from rabbit skin with healing inflammation

1965 • 57 citations

Multimolecular Forms of Thiol Proteinase Inhibitor in Human Plasma

1981 • 55 citations

Specific spectrophotometric assays for cathepsin B1

1975 • 54 citations

Pathogenesis of Human Muscular Dystrophies

1978 • 53 citations

Purification and some characteristics of two human serum proteins inhibiting papain and other thiol proteinases

1979 • 53 citations

Purification and Properties of Brain Cathepsin B

1979 • 53 citations

Elevated serum cathepsin B1-like activity in women with neoplastic disease

1979 • 52 citations

Immunochemical Difference between Cathepsin D and Cathepsin E-Like Enzyme from Rat Spleen

1980 • 48 citations

Zur Kenntnis des Kathepsins B′: Spezifität und Eigenschaften

1969 • 46 citations

Effects of chymostatin and other proteinase inhibitors on protein breakdown and proteolytic activities in muscle

1980 • 45 citations

Inhibitions of Cathepsin B and Cathepsin L by E-64 In Vivo. II. Incorporation of [3H]E-64 into Rat Liver Lysosomes In Vivo1

1982 • 44 citations

A new thiol proteinase from rat liver.

1981 • 43 citations

Elevated serum cathepsin B1 and vaginal pathology after prenatal DES exposure.

1978 • 42 citations

alpha-N-benzoylarginine-beta-naphthylamide hydrolase, an aminoendopeptidase from rabbit lung.

1980 • 40 citations

Inhibitions of degradation of rat liver aldolase and lactic dehydrogenase by N-[N-(L-3-trans-carboxyoxirane-2-carbonyl)-L-leucyl]agmatine or leupeptin in vivo

1980 • 40 citations

Purification and properties of thiol protease inhibitor from rat liver cytosol

1981 • 39 citations

BIOCHEMICAL STUDY OF CELLULAR ANTIGEN-ANTIBODY REACTION IN TISSUE CULTURE

1960 • 37 citations

Primary structure study of rat liver cathepsin B -----A striking resemblance to papain

1980 • 37 citations

Separation of a new protease from cathepsin B1 of rat liver lysosomes

1976 • 36 citations

Inactivation of cathepsin B1 by diazomethyl ketones

1977 • 34 citations

Endogenous thiol protease inhibitor from rat liver

1981 • 34 citations

The limited proteolysis of rabbit muscle aldolase by cathepsin B1

1978 • 34 citations

Effects of leupeptin and pepstatin on protein turnover in adult rat hepatocytes in primary culture

1981 • 34 citations

Purification and characterization of a factor catalyzing the conversion of the multiple forms of tyrosine aminotransferase from rat liver.

1980 • 34 citations

Modification of fructose bisphosphatase by a proteolytic enzyme from rat liver lysosomes

1978 • 33 citations

Characterization of three rabbit liver lysosomal proteinases with fructose 1,6-bisphosphatase converting enzyme activity

1981 • 31 citations

Effects of microbial proteinase inhibitors on the degradation of endogenous and internalized proteins by rat yolk sacs

1981 • 30 citations

Pepstatin-insensitive proteolytic activity of rat liver lysosomes. Isolation and purification of a new pepstatin-insensitive proteolytic enzyme from rat liver lysosomes.

1977 • 29 citations

Fractionation of the rat liver enzymes that hydrolyze benzoyl-arginine-2-naphthylamide

1975 • 29 citations

Regulation of Rabbit Liver Fructose-1, 6-diphosphatase

1974 • 26 citations

Fructose 1,6-Bisphosphatase: The Role of Lysosomal Enzymes in the Modification of Catalytic and Structural Properties

1973 • 25 citations

Limited proteolysis of liver and muscle aldolases: Effects of subtilisin, cathepsin B, and Staphylococcus aureus protease

1982 • 25 citations

Transformation of neutral to alkaline fructose 1,6-bisphosphatase

1974 • 24 citations

Purification and characterization of phosphodiesterase activator from kidney. A lysosomal protease.

1979 • 24 citations

alpha-N-Benzoylarginine-2-naphthylamide Hydrolase (Cathepsin B1?) from Rat Skin. I. Preliminary Experiments with Skin Extract.

1975 • 23 citations

Partial purification and characterization of a pyruvate dehydrogenase-complex-inactivating enzyme from rat liver

1978 • 22 citations

Changes in Activity and Molecular Properties of Fructose 1,6-Bisphosphatase During Fasting and Refeeding

1974 • 22 citations

Immunological Studies on Cathepsins B and H from Rat Liver1

1982 • 22 citations

Purification of Bovine Spleen Collagenolytic Cathepsin (Cathepsin N)

1978 • 20 citations

Proteolytic modification of rat liver fructose-1,6-bisphosphate aldolase by administration of leupeptin in vivo

1981 • 17 citations

Changes in activity of fructose-1,6-bisphosphate aldolase in livers of fasted rabbits and accumulation of crossreacting immune material.

1979 • 16 citations

Induction of hemoglobin-hydrolase activity by the thiol-protease inhibitors leupeptin and antipain in adult rat liver cells in primary culture

1979 • 15 citations

Properties of fructose-1,6-bisphosphate aldolase inactivating enzymes in rat liver lysosomes

1981 • 8 citations

alpha-N-Benzoylarginine-2-naphthylamide Hydrolase (Cathepsin B1?) from Rat Skin. III. Substrate Specificity, Modifier Characteristics, and Transfomation of the Enzyme at Acidic pH.

1976 • 7 citations

Changes during fasting in the activity of a specific lysosomal proteinase, fructose-1,6-bisphosphatase converting enzyme.

1981 • 5 citations

Modification of rat liver fructose biphosphate aldolase by lysosomal proteinases

1982 • 4 citations