Tumor hypoxia and heterogeneity: Challenges and opportunities for the future

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

1992 • 2,420 citations

Purification and Characterization of Hypoxia-inducible Factor 1

1995 • 2,010 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

1992 • 1,799 citations

Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model

1988 • 1,755 citations

Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma.

1993 • 1,646 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Carbon Monoxide: a Putative Neural Messenger

1993 • 1,519 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Barriers to Drug Delivery in Solid Tumors

1994 • 1,064 citations

Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein

1988 • 1,042 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

MAPKs: new JNK expands the group

1994 • 949 citations

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

1993 • 857 citations

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.

1989 • 698 citations

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1994 • 620 citations

Hypoxic fractions of solid tumors: Experimental techniques, methods of analysis, and a survey of existing data

1984 • 610 citations

Overexpression of Metallothionein Confers Resistance to Anticancer Drugs

1988 • 600 citations

Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis.

1995 • 598 citations

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

1994 • 517 citations

The current and potential role of hyperthermia in radiotherapy

1989 • 505 citations

Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues.

1994 • 449 citations

Does carbon monoxide have a physiological function?

1991 • 425 citations

Definitive evidence for hypoxic cells influencing cure in cancer therapy.

1978 • 422 citations

SR 4233 (Tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours

1993 • 354 citations

Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy.

1994 • 315 citations

Oxygen in Human Tumors: Correlations between Methods of Measurement and Response to Therapy: Summary of a Workshop Held November 19-20, 1992, at the National Cancer Institute, Bethesda, Maryland

1993 • 298 citations

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

1994 • 290 citations

Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Spl

1991 • 252 citations

Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia.

1994 • 241 citations

Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes

1993 • 206 citations

In situ hybridization and immunohistochemical localization of heme oxygenase-2 mRNA and protein in normal rat brain: Differential distribution of isozyme 1 and 2

1992 • 191 citations

Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.

1994 • 189 citations

Tumor Oxygenation: A New Predictive Parameter in Locally Advanced Cancer of the Uterine Cervix

1993 • 184 citations

Activation of the heat shock transcription factor by hypoxia in mammalian cells.

1990 • 173 citations

Drug Resistance in Oncology

1994 • 173 citations

Drug Resistance in Oncology

1997 • 160 citations

Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2).

1994 • 151 citations

Intracapillary oxyhemoglobin saturation of malignant tumors in humans

1981 • 131 citations

The identification of heme oxygenase as a major hypoxic stress protein in Chinese hamster ovary cells

1991 • 130 citations

Mechanisms and meaning of cellular oxygen sensing in the organism

1994 • 128 citations

Induction characteristics of oxygen regulated proteins

1986 • 121 citations

Regulation of c-jun Expression during Hypoxic and Low-Glucose Stress

1994 • 104 citations

Determination of local oxygen consumption rates in tumors.

1994 • 100 citations

Nimorazole as a hypoxic radiosensitizer in the treatment of supraglottic larynx and pharynx carcinoma. First report from the Danish Head and Neck Cancer Study (DAHANCA) protocol 5-85

1991 • 94 citations

Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism

1990 • 91 citations

Therapeutic Advantage of Hypoxic Cells in Tumors: A Theoretical Study

1991 • 91 citations

Potassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells.

1993 • 88 citations

Regulation of c-jun expression during hypoxic and low-glucose stress.

1994 • 79 citations

Molecular Machines that Control Genes

1995 • 68 citations

Role of Zinc-Coordination and of the Glutathione Redox Couple in the Redox Susceptibility of Human Transcription Factor Sp1

1994 • 63 citations

Metallothionein IIA is up-regulated by hypoxia in human A431 squamous carcinoma cells.

1994 • 63 citations

New trends in photobiology

1991 • 40 citations

Hypoxic stress induces reversible hypophosphorylation of pRB and reduction in cyclin A abundance independent of cell cycle progression.

1993 • 38 citations

Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908)

1992 • 25 citations

Enhancement of heme oxygenase expression and activity in A431 squamous carcinoma multicellular tumor spheroids.

1993 • 24 citations

Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549

1993 • 23 citations

Activators of protein kinase C selectively mediate cellular cytotoxicity to hypoxic cells and not aerobic cells

1994 • 13 citations

THE DANISH HEAD AND NECK CANCER STUDY GROUP (DAHANCA) RANDOMIZED TRIALS WITH HYPOXIC RADIOSENSITIZERS IN CARCINOMA OF THE LARYNX AND PHARYNX

1992 • 10 citations