Regulation of c-jun expression during hypoxic and low-glucose stress.

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

1988 • 1,699 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

1991 • 1,300 citations

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1988 • 1,256 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

Current Protocols in Molecular Biology

1989 • 1,007 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy

1991 • 906 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

Induction of proto-oncogene JUN/AP-1 by serum and TPA

1988 • 689 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers

1989 • 676 citations

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1991 • 626 citations

Parallel Association of Fos and Jun Leucine Zippers Juxtaposes DNA Binding Domains

1989 • 607 citations

Avian sarcoma virus 17 carries the jun oncogene.

1987 • 445 citations

Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity

1992 • 387 citations

Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells.

1988 • 380 citations

jun:Oncogene and Transcription Factor

1990 • 337 citations

Human heme oxygenase cDNA and induction of its mRNA by hemin

1988 • 320 citations

Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors.

1992 • 297 citations

Epidermal growth factor stimulates transcription of the c-jun proto-oncogene in rat fibroblasts

1988 • 289 citations

Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells.

1986 • 251 citations

Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors

1990 • 247 citations

Induction of glucose-regulated proteins during anaerobic exposure and of heat-shock proteins after reoxygenation.

1984 • 229 citations

Distal AP-1 binding sites mediate basal level enhancement and TPA induction of the mouse heme oxygenase-1 gene.

1992 • 194 citations

The identification of heme oxygenase as a major hypoxic stress protein in Chinese hamster ovary cells

1991 • 130 citations

Induction characteristics of oxygen regulated proteins

1986 • 121 citations

Modification of fos proteins: phosphorylation of c-fos, but not v-fos, is stimulated by 12-tetradecanoyl-phorbol-13-acetate and serum.

1987 • 112 citations

Selective Activation of Drugs by Redox Processes

1990 • 111 citations

Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance

1991 • 108 citations

Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation.

1992 • 102 citations

Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos protein.

1988 • 101 citations

Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistance.

1987 • 91 citations

Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism

1990 • 91 citations

Oncoprotein-Mediated Signalling Cascade Stimulates c-Jun Activity by Phosphorylation of Serines 63 and 73

1992 • 83 citations

A ubiquitous nuclear protein stimulates the DNA-binding activity of fos and jun indirectly.

1990 • 76 citations

Transcription factors junB and c-jun are selectively up-regulated and functionally implicated in fibrosarcoma development.

1992 • 67 citations

Normal Fibroblasts Responding to Anoxia Exhibit Features of the Malignant Phenotype

1989 • 58 citations

Anoxia-inducible endonuclease activity as a potential basis of the genomic instability of cancer cells.

1992 • 51 citations

Oxygen regulated 80 kDa protein and glucose regulated 78 kDa protein are identical

1991 • 45 citations

Enhanced epidermal growth factor receptor synthesis in human squamous carcinoma cells exposed to low levels of oxygen

1992 • 43 citations

Jun Is Phosphorylated by Several Protein Kinases at the Same Sites That Are Modified in Serum-Stimulated Fibroblasts

1992 • 39 citations

Activation of the heat shock transcription factor by hypoxia in normal and tumor cell lines in vivo and in vitro

1992 • 35 citations

Induction of c-jun protooncogene expression and transcription factor AP-1 activity by the polyoma virus middle-sized tumor antigen.

1992 • 34 citations

Negative regulation of the Saccharomyces cerevisiae ANB1 gene by heme, as mediated by the ROX1 gene product.

1986 • 31 citations

The Protein Kinase C Family: Heterogeneity And Its Implications

1989 • 28 citations

Retrotransposon-like VL30 elements are efficiently induced in anoxic rat fibroblasts

1989 • 24 citations

Determination of coexisting nuclear transcription rates and cytoplasmic mRNA levels for gonadotropin subunit genes in rat anterior pituitary.

1992 • 22 citations