Regulation of intracellular pH in the hepatocyte

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

Intracellular pH.

1981 • 2,440 citations

The Kidney: Physiology and Pathophysiology

1992 • 1,714 citations

Acid pH in tumors and its potential for therapeutic exploitation.

1989 • 1,633 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Molecular cloning, primary structure, and expression of the human growth factor-activatable antiporter

1989 • 774 citations

Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation

1989 • 749 citations

Mechanisms of regulation of the Na+/H+ exchanger

1986 • 685 citations

Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesicles

1982 • 681 citations

Metabolic regulation via intracellular pH

1984 • 674 citations

Kinetic Properties of the Plasma Membrane Na+ -H+ Exchanger

1985 • 670 citations

Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins.

1992 • 585 citations

Are cancer cells acidic?

1991 • 576 citations

Primary structure and transmembrane orientation of the murine anion exchange protein

1985 • 552 citations

Growth Factors Induce Phosphorylation of the Na ⁺ /H ⁺ Antiporter, a Glycoprotein of 110 kD

1990 • 452 citations

Rhodopsin, photoreceptor of the rod cell. An emerging pattern for structure and function.

1992 • 439 citations

pH regulation in single glomerular mesangial cells. I. Acid extrusion in absence and presence of HCO3-

1988 • 408 citations

Mechanisms and regulation of bile secretion

1991 • 402 citations

Increased sodium ion influx is necessary to initiate rat hepatocyte proliferation

1979 • 376 citations

Blockade of the Na+/H+ antiport abolishes growth factor-induced DNA synthesis in fibroblasts. Structure-activity relationships in the amiloride series.

1984 • 305 citations

Transport of H+ and of ionic weak acids and bases

1983 • 271 citations

Extracellular acidosis delays onset of cell death in ATP-depleted hepatocytes

1988 • 265 citations

Intracellular pH regulation in the renal proximal tubule of the salamander. Na-H exchange.

1983 • 258 citations

Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death.

1989 • 252 citations

Cytoplasmic pH, a key determinant of growth factor‐induced DNA synthesis in quiescent fibroblasts

1985 • 247 citations

Cell volume in the regulation of hepatic function: a mechanism for metabolic control

1991 • 225 citations

Intracellular Acid-Base Regulation. I. The Response of Muscle Cells to Changes in CO2 Tension or Extracellular Bicarbonate Concentration *

1965 • 201 citations

Increased pH and tumorigenicity of fibroblasts expressing a yeast proton pump

1988 • 193 citations

Effect of anoxia on intracellular ATP, Na+i, Ca2+i, Mg2+i, and cytotoxicity in rat hepatocytes.

1992 • 193 citations

Cloning and characterization of a murine band 3-related cDNA from kidney and from a lymphoid cell line.

1988 • 186 citations

Micro‐electrode measurement of the intracellular pH and buffering power of mouse soleus muscle fibres.

1977 • 184 citations

Mechanisms and Consequences of pH-Mediated Cell Regulation

1986 • 172 citations

Requirement of the Na+/H+ exchanger for tumor growth.

1989 • 166 citations

Immunohistochemical detection of chloride/bicarbonate anion exchangers in human liver

1994 • 165 citations

pH regulation in single glomerular mesangial cells. II. Na+-dependent and -independent Cl(-)-HCO3- exchangers

1988 • 160 citations

Cloning and structural characterization of a human non-erythroid band 3-like protein.

1986 • 155 citations

Hepatic Transport Systems Regulating pHi, Cell Volume, and Bile Secretion

1992 • 149 citations

Abnormal expression of anion exchanger genes in primary biliary cirrhosis

1993 • 137 citations

Na+-H+ exchange at the apical membrane of Necturus gallbladder. Extracellular and intracellular pH studies.

1982 • 136 citations

Hepatic Transport and Bile Secretion : Physiology and Pathophysiology

1992 • 136 citations

Protection by acidotic pH and fructose against lethal injury to rat hepatocytes from mitochondrial inhibitors, ionophores and oxidant chemicals

1990 • 128 citations

Direct measurement of intracellular pH and buffering power in smooth muscle cells of guinea‐pig vas deferens.

1984 • 119 citations

Effect of diabetes on Na(+)-H+ exchange by single isolated hepatocytes

1991 • 117 citations

Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles.

1985 • 115 citations

Cyclic AMP inhibits Na+/H+ exchange at the apical membrane of Necturus gallbladder epithelium.

1985 • 114 citations

Intracellular pH regulation in isolated rat bile duct epithelial cells.

1991 • 110 citations

Bicarbonate-dependent and -independent intracellular pH regulatory mechanisms in rat hepatocytes. Evidence for Na+-HCO3- cotransport.

1989 • 108 citations

Involvement of microtubules in the swelling-induced stimulation of transcellular taurocholate transport in perfused rat liver

1993 • 101 citations

Regulation of activity and apical targeting of the Cl-/HCO3- exchanger in rat hepatocytes.

1994 • 99 citations

Chloride-bicarbonate exchange and related transport processes

1982 • 92 citations

Hepatic role in pH regulation: role of the intercellular glutamine cycle

1984 • 90 citations

Metabolic aspects of the regulation of systemic pH

1987 • 90 citations

Importance of bicarbonate in bile salt independent fraction of bile flow.

1978 • 88 citations

Transport Polarity of Hepatocytes

1988 • 88 citations

Long-term expression of c-H-ras stimulates Na-H and Na(+)-dependent Cl-HCO3 exchange in NIH-3T3 fibroblasts.

1994 • 85 citations

Cell membrane and transepithelial voltages and resistances in isolated rat hepatocyte couplets

1987 • 84 citations

Cell Volume Regulation in Liver

1988 • 83 citations

Rat hepatocytes exhibit basolateral Na+/HCO3- cotransport.

1989 • 72 citations

The sinusoidal domain of the plasma membrane of rat hepatocytes contains an amiloride-sensitive Na+/H+ antiport.

1984 • 72 citations

Effects of osmotic stresses on isolated rat hepatocytes. I. Ionic mechanisms of cell volume regulation

1990 • 71 citations

Intracellular pH of isolated rat diaphragm muscle with metabolic and respiratory changes of extracellular pH

1975 • 67 citations

Na-H exchange regulates intracellular pH in isolated rat hepatocyte couplets

1987 • 66 citations

Profiles of expression of carbohydrate chain structures during human intrahepatic bile duct development and maturation: A lectin-histochemical and immunohistochemical study

1994 • 66 citations

Canalicular bile salt-independent bile formation: concepts and clues from electrolyte transport in rat liver

1983 • 66 citations

Na+-H+ exchange and Na+ entry across the apical membrane of Necturus gallbladder.

1984 • 65 citations

Mechanisms of Hepatic Electrolyte Transport

1983 • 63 citations

Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver

1989 • 63 citations

Hepatic Transport of Organic Substances

1989 • 60 citations

Separate regulatory control of apical and basolateral Na+/H+ exchange in renal epithelial cells

1989 • 56 citations

Na-H exchange in rat liver basolateral but not canalicular plasma membrane vesicles

1986 • 56 citations

Cloning, sequencing, and expression of Na(+)-H+ antiporter cDNAs from human tissues

1992 • 56 citations

Regulatory volume decrease stimulates bile flow, bile acid excretion, and exocytosis in isolated perfused rat liver

1992 • 52 citations

Na+-H+ exchange activity in rat hepatocytes: role in regulation of intracellular pH

1989 • 51 citations

Electrophysiological evidence for Na+-coupled bicarbonate transport in cultured rat hepatocytes

1989 • 51 citations

Cl(-)-HCO3- exchanger in isolated rat hepatocytes: role in regulation of intracellular pH

1991 • 50 citations

The effect of urea synthesis on extracellular pH in isolated perfused rat liver

1986 • 49 citations

Inhibition of Na+/H+ exchange in the rat is associated with decreased ursodeoxycholate hypercholeresis, decreased secretion of unconjugated ursodeoxycholate, and increased ursodeoxycholate glucuronidation

1988 • 47 citations

Intracellular pH dependence of buffer capacity and anion exchange in the parietal cell

1989 • 45 citations

Effects of osmotic stresses on isolated rat hepatocytes. II. Modulation of intracellular pH

1990 • 44 citations

Intracellular pH regulation in rabbit S3 proximal tubule: basolateral Cl-HCO3 exchange and Na-HCO3 cotransport

1990 • 41 citations

Effect of UDCA on intracellular and biliary pH in isolated rat hepatocyte couplets and perfused livers

1991 • 38 citations

Ionic requirements for intracellular pH regulation in rainbow trout hepatocytes

1986 • 38 citations

Electroneutral secretion of bicarbonate by guinea pig gallbladder epithelium

1986 • 34 citations

Acid-base transport systems in gastrointestinal epithelia.

1992 • 30 citations

mechanism of glucagon choleresis in guinea pigs

1990 • 29 citations

Cyclic AMP inhibits Cl-/HCO3- exchange at the apical membrane of Necturus gallbladder epithelium.

1987 • 28 citations

Insulin-Dependent Diabetes Mellitus and Hypertension

1991 • 28 citations

Hepatocellular Na+/H+ exchange is activated at transcriptional and posttranscriptional levels in rat biliary cirrhosis

1994 • 26 citations

Intracellular chloride activity in intact rat liver: relationship to membrane potential and bile flow

1987 • 25 citations

Intracellular pH regulation in hep G2 cells: Effects of epidermal growth factor, transforming growth factor-α, and insulinlike growth factor-II on Na+/H+ exchange activity

1995 • 24 citations

Characterization of H+ efflux pathways in rat hepatocytes

1988 • 24 citations

Effects of Na+ replacement and amiloride on ursodeoxycholic acid-stimulated choleresis and biliary bicarbonate secretion

1987 • 24 citations

Na+/H+ exchange: What, where and why?

1988 • 23 citations

Intracellular calcium-mediated activation of hepatic Na+/H+ exchange by arginine vasopressin and phenylephrine

1992 • 22 citations

Sodium-proton exchanger in isolated hepatocytes exhibits a set point

1988 • 21 citations

Effect of intracellular pH on potassium conductance in liver

1988 • 21 citations

Different modulation of hepatocellular Na+/H+ exchange activity by insulin and EGF

1994 • 19 citations

Characterization of signaling pathways to na+/H+ exchanger activation with epidermal growth factor in hepatocytes

1994 • 19 citations

Chloride transport by intact rat liver and cultured rat hepatocytes

1982 • 17 citations

Species differences between rat and rabbit renal Na+/H+ exchangers

1987 • 16 citations

Regulation of hepatic Na(+)-HCO3- cotransport and pH by membrane potential difference

1993 • 16 citations

HCO 3 − -coupled Na+ influx is a major determinant of Na+ turnover and Na+/K+ pump activity in rat hepatocytes

1991 • 16 citations

pH regulation in perfused rat liver: respective role of Na(+)-H+ exchanger and Na(+)-HCO3- cotransport

1993 • 15 citations

Molecular biology of renal Na(+)-H+ exchangers.

1991 • 14 citations

Regulation of intracellular pH in isolated periportal and perivenular rat hepatocytes

1993 • 14 citations

Plasma membrane H(+)-HCO3- transport in rat hepatocytes: a principal role for Na(+)-coupled HCO3- transport

1991 • 13 citations

Mechanisms and functional role of intracellular pH regulation in hepatocytes.

1993 • 12 citations

Effects of high and low pH on Ca2+i and on cell injury evoked by anoxia in perfused rat hepatocytes

1994 • 11 citations

Role of bicarbonate in biliary excretion of diisothiocyanostilbene disulfonate

1988 • 11 citations

Transport Processes in Mammalian Gallbladder and Bile Duct

1989 • 3 citations

Microtubule dependent targeting of transporters to the apical membrane determines the canalicular excretion of bile acids in hepatocyte couplets . Dept Medicine and Liver Center, Yale University School of Medicine, New Haven, CT

1993 • 3 citations

Abnormal expression of anion exchanger ae genes in primary biliary cirrhosis pbc

1992 • 1 citations