Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study

1993 • 1,283 citations

Resistance to Activated Protein C as a Basis for Venous Thrombosis

1994 • 1,148 citations

The mechanism of inactivation of human factor V and human factor Va by activated protein C.

1994 • 413 citations

Inherited resistance to activated protein C iscorrected by anticoagulant cofactor activity found to be a property of factorV.

1994 • 359 citations

Continuous Registration of Thrombin Generation in Plasma, Its Use for the Determination of the Thrombin Potential

1993 • 332 citations

A Reduced Sensitivity for Activated Protein C in the Absence of Factor V Leiden Increases the Risk of Venous Thrombosis

1999 • 309 citations

Factor V and protein S as synergistic cofactors to activated protein C in degradation of factor VIIIa.

1994 • 307 citations

Factor V Cambridge: A New Mutation (Arg306→Thr) Associated With Resistance to Activated Protein C

1998 • 281 citations

Peptide Bond Cleavages and Loss of Functional Activity during Inactivation of Factor Va and Factor VaR506Q by Activated Protein C

1995 • 243 citations

Characterization of the Molecular Defect in Factor VR506A

1995 • 230 citations

A Factor V Genetic Component Differing From Factor V R506Q Contributes to the Activated Protein C Resistance Phenotype

1997 • 213 citations

A Novel Mutation of Arg306 of Factor V Gene in Hong Kong Chinese

1998 • 210 citations

Factor V and Thrombotic Disease

2002 • 207 citations

Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity.

1991 • 189 citations

Regulation of blood coagulation by the protein C system

1992 • 179 citations

Phenotyping the Clotting System

2000 • 160 citations

Detection of new polymorphic markers in the factor V gene: association with factor V levels in plasma.

1996 • 146 citations

A prospective study of venous thromboembolism in relation to factor V Leiden and related factors

2002 • 142 citations

Activated protein C resistance: molecular mechanisms based on studies using purified Gln506-factor V

1995 • 131 citations

Detection of New Polymorphic Markers in the Factor V Gene: Association with Factor V Levels in Plasma

1996 • 121 citations

Functional characterization of recombinant FV Hong Kong and FV Cambridge

2002 • 119 citations

Coinheritance of the HR2 Haplotype in the Factor V Gene Confers an Increased Risk of Venous Thromboembolism to Carriers of Factor V R506Q (Factor V Leiden)

1999 • 118 citations

Factor V Enhances the Cofactor Function of Protein S in the APC-Mediated Inactivation of Factor VIII: Influence of the Factor VR506Q Mutation

1996 • 115 citations

Cleavage of Factor V at Arg 506 by Activated Protein C and the Expression of Anticoagulant Activity of Factor V

1999 • 109 citations

Comparison of activated protein C/protein S-mediated inactivation of human factor VIII and factor V

1996 • 105 citations

The HR2 Haplotype of Factor V: Effects on Factor V Levels, Normalized Activated Protein C Sensitivity Ratios and the Risk of Venous Thrombosis

2000 • 93 citations

Characterization of two forms of human factor Va with different cofactor activities.

1993 • 93 citations

“Pseudo Homozygous” Activated Protein C Resistance due to Double Heterozygous Factor V Defects (Factor V Leiden Mutation and Type I Quantitative Factor V Defect) Associated with Thrombosis: Report of Two Cases Belonging to Two Unrelated Kindreds

1996 • 84 citations

The C-terminal Region of the Factor V B-domain Is Crucial for the Anticoagulant Activity of Factor V

1998 • 77 citations

The discovery of activated protein C resistance

2003 • 67 citations

Molecular mechanisms of activated protein C resistance. Properties of factor V isolated from an individual with homozygosity for the Arg506 to Gln mutation in the factor V gene

1996 • 55 citations

Coinheritance of Factor V (FV) Leiden enhances thrombin formation and is associated with a mild bleeding phenotype in patients homozygous for the FVII 9726+5G>A (FVII Lazio) mutation

2003 • 48 citations

Functional Properties of Factor V and Factor Va Encoded by the R2-gene

2001 • 48 citations

The factor V HR2 haplotype and the risk of venous thrombosis: a meta-analysis.

2003 • 46 citations

Purified Protein S Contains Multimeric Forms with Increased APC-Independent Anticoagulant Activity

2001 • 44 citations

The discovery of factor V: a tricky clotting factor

2003 • 34 citations

A chromogenic assay for activated protein C resistance

1995 • 27 citations

The activated protein C (APC)-resistant phenotype of APC cleavage site mutants of recombinant factor V in a reconstituted plasma model

2002 • 17 citations

An Assay to Quantify the Two Plasma Isoforms of Factor V

2000 • 13 citations

Reduced Factor V Concentration and Altered FV1/FV2 Ratio do not fully Explain R2-associated APC-resistance

2002 • 10 citations

The factor V Leiden mutation results in the in vivo loss of a critical FV anticoagulant function

2003 • 2 citations