A Factor V Genetic Component Differing From Factor V R506Q Contributes to the Activated Protein C Resistance Phenotype

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

World distribution of factor V Leiden

1995 • 1,184 citations

Resistance to Activated Protein C as a Basis for Venous Thrombosis

1994 • 1,148 citations

The Roles of Protein C and Thrombomodulin in the Regulation of Blood Coagulation

1989 • 1,059 citations

Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins

1996 • 593 citations

Inherited thrombophilia: pathogenesis, clinical syndromes, and management [see comments]

1996 • 438 citations

Complete cDNA and derived amino acid sequence of human factor V.

1987 • 416 citations

Characterization of the Molecular Defect in Factor VR506A

1995 • 230 citations

Laboratory Diagnosis of APC-Resistance: A Critical Evaluation of the Test and the Development of Diagnostic Criteria

1994 • 199 citations

The Population Genetics of Factor V Leiden (Arg506Gln)

1996 • 154 citations

Detection of new polymorphic markers in the factor V gene: association with factor V levels in plasma.

1996 • 146 citations

Detection of New Polymorphic Markers in the Factor V Gene: Association with Factor V Levels in Plasma

1996 • 121 citations

Resistance to Activated Protein C, the Arg506 to Gin Mutation in the Factor V Gene, and Venous Thrombosis

1995 • 117 citations

Comparison of activated protein C/protein S-mediated inactivation of human factor VIII and factor V

1996 • 105 citations

Post-translational requirements for functional factor V and factor VIII secretion in mammalian cells.

1994 • 101 citations

“Pseudo Homozygous” Activated Protein C Resistance due to Double Heterozygous Factor V Defects (Factor V Leiden Mutation and Type I Quantitative Factor V Defect) Associated with Thrombosis: Report of Two Cases Belonging to Two Unrelated Kindreds

1996 • 84 citations

Proteolysis of factor Va by factor Xa and activated protein C.

1987 • 77 citations

Evidence for a single origin of factor V Leiden

1996 • 60 citations

Molecular mechanisms of activated protein C resistance. Properties of factor V isolated from an individual with homozygosity for the Arg506 to Gln mutation in the factor V gene

1996 • 55 citations

The serine protease cofactor factor V is synthesized by lymphocytes.

1993 • 28 citations

A polymorphism in the human coagulation factor V gene.

1994 • 16 citations