Inherited resistance to activated protein C iscorrected by anticoagulant cofactor activity found to be a property of factorV.

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

The coagulation cascade: initiation, maintenance, and regulation

1991 • 1,810 citations

The molecular basis of blood coagulation

1988 • 1,240 citations

The Roles of Protein C and Thrombomodulin in the Regulation of Blood Coagulation

1989 • 1,059 citations

COFACTOR PROTEINS IN THE ASSEMBLY AND EXPRESSION OF BLOOD CLOTTING ENZYME COMPLEXES

1988 • 535 citations

Regulation of activated protein C by a new protein. A possible function for bovine protein S.

1980 • 460 citations

Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders

1988 • 405 citations

Protein S and C4b-Binding Protein: Components Involved in the Regulation of the Protein C Anticoagulant System

1991 • 357 citations

Thrombin-catalyzed activation of human coagulation factor V.

1982 • 274 citations

Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C.

1993 • 220 citations

Direct detection of activated protein C in blood from human subjects

1992 • 179 citations

Human coagluation factor V purification and thrombin-catalyzed activation.

1980 • 145 citations

Characterization of functionally important domains in human vitamin K-dependent protein S using monoclonal antibodies.

1990 • 112 citations

The binding of activated protein C to factors V and Va.

1986 • 91 citations

The effect of phospholipids, calcium ions and protein S on rate constants of human factor Va inactivation by activated human protein C

1992 • 83 citations

Factor V inhibitor in thrombosis

1993 • 46 citations

Ultrastructural localization of coagulation factor V in human platelets

1986 • 29 citations

Bovine coagulation factor V visualized with electron microscopy. Ultrastructure of the isolated activated forms and of the activation fragments.

1986 • 24 citations