Induction and Suppression of Polyclonal Antibody Responses by Anti‐Ig Reagents and Antigen‐Nonspecific Helper Factors:

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

Properties of Monoclonal Antibodies to Mouse Ig Allotypes, H-2, and Ia Antigens

1979 • 993 citations

Replacement of T-Cell Function by a T-Cell Product

1972 • 537 citations

Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharides

1972 • 431 citations

STUDIES ON RABBIT LYMPHOCYTES IN VITRO

1965 • 418 citations

Membrane and Cytoplasmic Changes in B Lymphocytes Induced by Ligand-Surface Immunoglobulin Interaction

1976 • 383 citations

T-T-cell interactions during the vitro cytotoxic allograft responses. I. Soluble products from activated Lyl+ T cells trigger autonomously antigen-primed Ly23+ T cells to cell proliferation and cytolytic activity.

1978 • 330 citations

Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.

1978 • 316 citations

Thymus-Independent B-Cell Induction and Paralysis

1975 • 304 citations

Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines.

1979 • 301 citations

Idiotype‐specific T helper cells are required to induce idiotype‐positive B memory cells to secrete antibody

1978 • 268 citations

Revised Nomenclature for Antigen-Nonspecific T Cell Proliferation and Helper Factors

1979 • 223 citations

The role of mitogenic lectins in T-cell triggering

1979 • 211 citations

Activation of mouse lymphocytes by anti-immunoglobulin. I. Parameters of the proliferative response.

1978 • 180 citations

STUDIES ON RABBIT LYMPHOCYTES IN VITRO

1965 • 156 citations

Stimulation of mouse lymphocytes by insoluble anti-mouse immunoglobulin

1975 • 154 citations

Proliferation of Murine Thymic Lymphocytes in Vitro Is Mediated by the Concanavalin A-Induced Release of a Lymphokine (Costimulator)

1976 • 151 citations

Studies on T lymphocyte activation II. The target cells for concanavalin A‐induced growth factors

1979 • 141 citations

Requirement for Cross-Linkage in the Stimulation of Transformation of Rabbit Peripheral Lymphocytes by Antiglobulin Reagents

1970 • 131 citations

B Lymphocyte: Activation by Insoluble Anti-Immunoglobulin: Induction of Immunoglobulin Secretion by a T Cell-Dependent Soluble Factor

1979 • 128 citations

Control of B-lymphocyte function. I. Inactivation of mitogenesis by interactions with surface immunoglobulin and Fc-receptor molecules.

1976 • 123 citations

Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies.

1975 • 119 citations

IgD and IgM on the membrane of lymphoid cells in macroglobulinemia. Evidence for identity of membrane IgD and IgM antibody activity in a case with anti‐IgG receptors

1974 • 110 citations

Absolute frequencies of lipopolysaccharide-reactive B cells producing A5A idiotype in unprimed, streptococcal A carbohydrate-primed, anti-A5A idiotype-sensitized and anti-A5A idiotype-suppressed A/J mice.

1977 • 104 citations

Summary: Waiting for the End

1967 • 102 citations

Activation of mouse lymphocytes by anti-immunoglobulin. II. A thymus-independent response by a mature subset of B lymphocytes.

1978 • 100 citations

A Third Signal in B Cell Activation Given by TRF

1975 • 95 citations

Physical Chemical Aspects of Cell Surface Events in Cellular Regulation

1980 • 94 citations

Role of IgD in the immune response and tolerance. I. Anti-delta pretreatment facilitates tolerance induction in adult B cells in vitro.

1977 • 93 citations

Antigen-specific and nonspecific mediators of T cell/B cell cooperation. III. Characterization of the nonspecific mediator(s) from different sources.

1976 • 85 citations

STUDIES ON RABBIT LYMPHOCYTES IN VITRO

1965 • 79 citations

Cellular cooperation during in vivo anti-hapten antibody responses. I. The effect of cell number on the response.

1975 • 77 citations

Activation of murine B lymphocytes by anti-immunoglobulin is an inductive signal leading to immunoglobulin secretion.

1980 • 77 citations

Multiple Pathways of B Lymphocyte Tolerance

1979 • 76 citations

STUDIES ON RABBIT LYMPHOCYTES IN VITRO

1965 • 76 citations

F(ab′)2 Reagents Are not Required If Goat, Rather Than Rabbit, Antibodies Are Used to Detect Human Surface Immunoglobulin

1977 • 75 citations

Anti-immunoglobulin stimulation of murine lymphocytes. I. Age dependency of the proliferative response.

1976 • 75 citations

Separate Signals for the Initiation of Proliferation and Differentiation in the B Cell Response to Antigen

1975 • 74 citations

Regulation of antibody response in vitro. IX. Induction of secondary anti-hapten IgG antibody response by anti-immunoglobulin and enhancing soluble factor.

1975 • 67 citations

Immunological B Memory in Thymus Deprived Mice

1972 • 67 citations

Direct blockade of antigen-reactive B lymphocytes by immune complexes. An 'off' signal for precursors of IgM-producing cells provided by the linkage of antigen-and Fc-receptors.

1978 • 66 citations

The role of surface IgD in the response to thymic-independent antigens.

1977 • 66 citations

Control of proliferation and differentiation in B lymphocytes by anti-Ig antibodies and a serum-derived cofactor.

1978 • 65 citations

Functional analysis of T cells expressing Ia antigens. I. Demonstration of helper T-cell heterogeneity.

1979 • 60 citations

Role of a nonimmunoglobulin cell surface determinant in the activation of B lymphocytes by thymus-independent antigens.

1979 • 59 citations

Regulation of the immune response. VI. Inability of F(ab') 2 antibody to terminate established immune responses and its ability to interfere with IgG antibody-mediated immunosuppression.

1973 • 58 citations

The Role of T Cells in IgG Production; Thymus-Dependent Antigens Induce B Cell Memory in the Absence of T Cells

1975 • 58 citations

The differentiation function of T cell‐replacing factor in nu/nu spleen cell cultures

1974 • 54 citations

Anti-Immunoglobulin Stimulation of Murine Lymphocytes

1976 • 53 citations

Requirements for Mitogenic Stimulation of Murine B Cells by Soluble Anti-IgM Antibodies

1979 • 53 citations

Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD.

1978 • 52 citations

Anti-immunoglobulin stimulation of murine lymphocytes. V. Age-related decline in Fc receptor-mediated immunoregulation.

1978 • 52 citations

Cellular Cooperation During in Vivo Anti-Hapten Antibody Responses

1975 • 51 citations

Anti-immunoglobulin stimulation of murine lymphocytes. II. Identification of cell surface target molecules and requirements for cross-linkage.

1976 • 50 citations

Experimental Malaria in the CBA/N Mouse

1979 • 49 citations

The Role of Receptor IgM and IgD in Determining Triggering and Induction of Tolerance in Murine B Cells¹

1979 • 48 citations

AUTORADIOGRAPHIC STUDIES ON THE PROLIFERATION OF ANTIBODY-PRODUCING CELLS IN VITRO

1974 • 48 citations

Antigen-Specific and Nonspecific Mediators of T Cell/B Cell Cooperation

1976 • 47 citations

Two stages of B-cell memory development with different T-cell requirements.

1976 • 46 citations

Anti-Immunoglobulin Stimulation of Murine Lymphocytes

1978 • 40 citations

Partial characterization and purification of murine T cell-replacing factor, TRF—II

1978 • 40 citations

Studies on the generation and expression of H‐2‐controlled T helper function in chimeric mice: Evidence for two levels of H‐2 restriction

1979 • 40 citations

Accessory cell requirement for anti-IgM-induced proliferation of B lymphocytes

1978 • 29 citations

Nonspecific “Lymphocyte Activating” Factors Produced by Macrophages

1979 • 28 citations

Isolation and characterization of lectin binding proteins from murine lymphoid cells

1978 • 25 citations

Antigenic marker on a functional subpopulation of B cells, controlled by the I-A subregion of the H-2 complex.

1979 • 25 citations

POLYCLONAL MITOGENS AND THE NATURE OF B LYMPHOCYTE ACTIVATION MECHANISMS

1974 • 19 citations

Proliferative Response to Anti-IgM Antibodies of Various B Lymphocyte Subpopulations Isolated by Cell Sorting

1978 • 18 citations

Antigen-Receptor Interactions in the Induction of B-Lymphocyte Unresponsiveness

1977 • 14 citations

Anti-immunoglobulin stimulation of murine lymphocytes. IV. Re-expression and fate of cell surface receptors during stimulation.

1978 • 13 citations

Anti-Immunoglobulin Stimulation of Murine Lymphocytes

1978 • 9 citations

The response of murine splenic lymphocytes to concanavalin A and to co-stimulator.

1980 • 8 citations