Correlations between Three-dimensional Structure and Function of Immunoglobulins

Stereochemistry of Cooperative Effects in Haemoglobin: Haem–Haem Interaction and the Problem of Allostery

1970 • 2,874 citations

Atlas of Protein Sequence and Structure, 1972.

1973 • 2,408 citations

The hydrolysis of rabbit γ-globulin and antibodies with crystalline papain

1959 • 2,294 citations

Dynamics of folded proteins

1977 • 1,929 citations

SEROLOGICAL REACTIONS IN PNEUMONIA WITH A NON-PROTEIN SOMATIC FRACTION OF PNEUMOCOCCUS

1930 • 1,460 citations

Chemical and biological evolution of a nucleotide-binding protein

1974 • 1,457 citations

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

1970 • 1,308 citations

Separation of univalent fragments from the bivalent rabbit antibody molecule by reduction of disulfide bonds

1960 • 901 citations

THE COVALENT STRUCTURE OF AN ENTIRE γG IMMUNOGLOBULIN MOLECULE

1969 • 869 citations

Protein crystallography

1977 • 713 citations

Three-Dimensional Structure of Immunoglobulins

1979 • 692 citations

Structure and function of haemoglobin

1965 • 603 citations

Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin.

1974 • 561 citations

Variability in the Lambda Light Chain Sequences of Mouse Antibody

1970 • 554 citations

Electron microscopy of an antibody-hapten complex

1967 • 505 citations

The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site

1974 • 465 citations

Segmental flexibility in an antibody molecule

1970 • 465 citations

Antigenicity: Some Molecular Aspects

1969 • 418 citations

Crystallographic structure studies of an IgG molecule and an Fc fragment

1976 • 416 citations

β ₂ -Microglobulin—A Free Immunoglobulin Domain

1972 • 387 citations

Three-Dimensional Structure of the Fab′ Fragment of a Human Immunoglobulin at 2.8-Å Resolution

1973 • 381 citations

Interaction of C-Reactive Protein Complexes with the Complement System

1974 • 357 citations

Structure of a λ-type Bence-Jones protein at 3.5-Å resolution

1973 • 356 citations

Preliminary refinement and structural analysis of the Fab fragment from human immunoglobulin new at 2.0 A resolution.

1978 • 293 citations

THE OCCURRENCE DURING ACUTE INFECTIONS OF A PROTEIN NOT NORMALLY PRESENT IN THE BLOOD

1941 • 283 citations

Complete Amino Acid Sequence of the Mu Heavy Chain of a Human IgM Immunoglobulin

1973 • 270 citations

INTERACTIONS OF C-REACTIVE PROTEIN WITH THE COMPLEMENT SYSTEM

1974 • 258 citations

THE EVOLUTIONARY ORIGINS OF THE IMMUNOGLOBULINS

1966 • 258 citations

The Three-Dimensional Structure at 6 A Resolution of a Human γG1 Immunoglobulin Molecule

1971 • 249 citations

The Antibody Molecule

2014 • 239 citations

Crystal and Molecular Structure of a Dimer Composed of the Variable Portions of the Bence-Jones Protein REI

1974 • 231 citations

The Three Dimensional Structure of a Combining Region-Ligand Complex of Immunoglobulin NEW at 3.5-Å Resolution

1974 • 227 citations

Three-Dimensional Structure of Immunoglobulins

1975 • 218 citations

Rotational allomerism and divergent evolution of domains in immunoglobulin light chains

1975 • 217 citations

A SUBCLASS OF HUMAN γA-GLOBULINS (γA2) WHICH LACKS THE DISULFIDE BONDS LINKING HEAVY AND LIGHT CHAINS

1968 • 217 citations

The Nature of an Antigenic Determinant

1966 • 217 citations

On the Specificity of Antibodies

1975 • 217 citations

The Three-Dimensional Structure of the Fab′ Fragment of a Human Myeloma Immunoglobulin at 2.0-Å Resolution

1974 • 213 citations

Gross Conformation of Rabbit 7 S γ-Immunoglobulin and Its Papain-cleaved Fragments

1965 • 212 citations

ATTEMPTS TO LOCATE COMPLEMENTARITY‐DETERMINING RESIDUES IN THE VARIABLE POSITIONS OF LIGHT AND HEAVY CHAINS *

1971 • 212 citations

Structure and function of the constant regions of immunoglobulins

1976 • 206 citations

Structure and Function of γ Macroglobulins

1970 • 206 citations

Effect of Antigen Binding on the Properties of Antibody

1974 • 182 citations

The immune system: Genes, receptors, signals

1973 • 169 citations

Penicillopepsin from Penicillium janthinellum crystal structure at 2.8 Å and sequence homology with porcine pepsin

1977 • 168 citations

Binding of 2,4-dinitrophenyl compounds and other small molecules to a crystalline .lambda.-type Bence-Jones dimer

1974 • 164 citations

Similarity of three-dimensional structure between the immunoglobulin domain and the copper, zinc superoxide dismutase subunit

1976 • 162 citations

Receptors and Recognition

1977 • 155 citations

The structure and function of immunoglobulin domains. II. The importance of interchain disulfide bonds and the possible role of molecular flexibility in the interaction between immunoglobulin G and complement.

1975 • 154 citations

The antibody binding site. Labelling of a specific antibody against the photo-precursor of an aryl nitrene

1972 • 152 citations

Bence-Jones Proteins and Light Chains of Immunoglobulins

1976 • 152 citations

Structure of the human antibody molecule kol (immunoglobulin G1): An electron density map at 5 Å resolution

1976 • 148 citations

Gene Triplication deduced from the Tertiary Structure of a Muscle Calcium Binding Protein

1972 • 129 citations

Interactions of C-reactive protein with the complement system. II. C-reactive protein-mediated consumption of complement by poly-L-lysine polymers and other polycations.

1975 • 125 citations

Crystallographic Structural Studies of a Human Fc Fragment. II. A Complete Model Based on a Fourier Map at 3.5 Å Resolution

1976 • 123 citations

The disulphide bonds of the heavy chain of rabbit immunoglobulin G

1970 • 122 citations

X-ray Crystallographic Studies of Proteins

1976 • 114 citations

Structure at 4.5 Å; Resolution of a Phosphorylcholine-binding Fab

1973 • 113 citations

Kinetic mapping of the antibody combining site by chemical relaxation spectrometry

1974 • 113 citations

The amino acid sequences of the Fd fragments of two human γ 1 heavy chains

1970 • 104 citations

THE FIXATION OF COMPLEMENT AND THE ACTIVATED FIRST COMPONENT (C1) OF COMPLEMENT BY COMPLEXES FORMED BETWEEN ANTIBODY AND DIVALENT HAPTEN

1970 • 97 citations

Evolutionary relationship between immunoglobulins and transplantation antigens.

1975 • 97 citations

Kinetic evidence for hapten-induced conformational transition in immunoglobin MOPC 460.

1976 • 95 citations

Structure of Fab New at 6 Å Resolution

1972 • 95 citations

The Use of X‐Ray Diffraction in the Study of Protein and Nucleic Acid Structure

1965 • 95 citations

Structure of an antibody combining site by magnetic resonance

1977 • 89 citations

Primary structure of the Mcg _λ chain

1974 • 89 citations

The Structure and Function of Immunoglobulin Domains

1975 • 87 citations

X-Ray Analysis and Protein Structure

1957 • 86 citations

Three-dimensional structure, function and genetic control of immunoglobulins

1975 • 80 citations

Shape and volume of anti-poly-D-alanyl antibodies in the presence and absence of tetra-D-alanine as followed by small-angle x-ray scattering

1973 • 79 citations

Affinity labeling of a mouse myeloma protein which binds nitrophenyl ligands. Sequence and position of a labeled tryptic peptide

1970 • 78 citations

The Principles and Practice of Medicine.

1972 • 77 citations

Structure and Evolution of Kappa and Lambda Light Chains

1967 • 75 citations

X-Ray Diffraction Studies of Immunoglobulins

1975 • 64 citations

Affinity labeling and cross-linking of the heavy and light chains of a myeloma protein with anti-2,4-dinitrophenol activity

1971 • 64 citations

Localization of Two Additional Hypervariable Regions in Immunoglobulin Heavy Chains

1971 • 63 citations

Dynamics of hapten-antibody interaction. Studies on a myeloma protein with anti-2, 4-dinitrophenyl specificity

1972 • 63 citations

Structural Rules for Globular Proteins

1977 • 63 citations

The Interchain Disulfide Bonds of a Human Pathological Immunoglobulin^*

1967 • 62 citations

Size differences among immunoglobulin heavy chains from phosphorylcholine-binding proteins.

1976 • 61 citations

The role of the inter-heavy chain disulfide bond in modulating the flexibility of immunoglobulin G antibody

1977 • 60 citations

Specific interaction between VH and VL regions of human monoclonal immunoglobulins

1976 • 60 citations

The ultrastructure of carp (Cyprinus carpio) immunoglobulin: A tetrameric macroglobulin

1970 • 60 citations

A Structural Feature of Human Immunoglobulin Light Chains

1972 • 58 citations

The structure determination of the variable portion of the Bence-Jones protein Au

1975 • 56 citations

Variability of Interchain Binding of Immunoglobulins: Interchain Bridges of Mouse IgG2a and IgG2b

1970 • 55 citations

Recurrence of the cytochrome fold in a nitrate-respiring bacterium

1973 • 53 citations

Immunoglobulin E (Reagin) and Allergy

1971 • 51 citations

Amino acid sequence of the light chain derived from a rabbit anti-p-azobenzoate antibody of restricted heterogeneity

1973 • 50 citations

Detection of a conformational change in an antihapten-antibody system upon interaction with divalent hapten

1970 • 47 citations

Crystallization of Fragment Fab of human IgG myeloma proteins

1968 • 47 citations

Primary structure of C-1-a₁--- a cyanogen bromide fragment of heavy chain from inbred guinea pig immunoglobulin G(2), which contains a markedly variable segment

1971 • 47 citations

Fluorescence polarization and intensity kinetic studies of antifluorescein antibody obtained at different stages of the immune response

1975 • 46 citations

Electron microscopy of human and mouse myeloma serum IgA

1971 • 46 citations

FIRST ORDER CONSIDERATIONS IN ANALYZING THE GENERATOR OF DIVERSITY

1974 • 45 citations

Amino acid sequence change associated with genetic marker Inv(2) of human immunoglobulin

1974 • 44 citations

Affinity Labeling by m-Nitrobenzenediazonium Fluoroborate of Porcine Anti-Dinitrophenyl Antibodies. Position of Labeled Tyrosine in the lamba-Chains

1971 • 43 citations

Shape and volume of fragments Fab' and (Fab')2 of anti-poly(D-alanyl) antibodies in the presence and absence of tetra-D-alanine as determined by small-angle x-ray scattering

1975 • 43 citations

A new λ-chain gene

1975 • 42 citations

MAPPING OF THE COMBINING SITES OF ANTIBODIES SPECIFIC TO POLYALANINE CHAINS

1971 • 41 citations

The three-dimensional structure of crystalline porcine pancreatic elastase

1970 • 40 citations

Localization of affinity-labeled residues in the primary structure of antidinitrophenyl antibody raised in strain 13 guinea pigs

1972 • 39 citations

Studies on the three-dimensional structure of immunoglobulins

1978 • 38 citations

An Active Derivative of Rabbit Antibody Light Chain Composed of the Constant and the Variable Domains Held Together Only by a Native Disulfide Bond

1972 • 37 citations

HETEROGENEITY AND STRUCTURE OF ANTIBODY‐COMBINING SITES*

1970 • 37 citations

Amino acid sequence of the λ light chain of a human myeloma immunoglobulin (IgG new)

1974 • 37 citations

Hapten stabilization of antibody conformation

1970 • 36 citations

Thermodynamics of the binding of 2,4-dinitrophenyl and 2,4,6-trinitrophenyl haptens to the homologous and heterologous rabbit antibodies

1972 • 36 citations

Specificity of Antibodies: Primary Structural Basis of Hapten Binding

1974 • 36 citations

Human and murine phosphorycholine-binding immunoglobulins: conserved subgroup and first hypervariable region of heavy chains.

1976 • 35 citations

Affinity Labeling of the Heavy and Light Chains of a Myeloma Protein with Anti-2,4-Dinitrophenyl Activity

1970 • 35 citations

DISCUSSION

1970 • 35 citations

Thermodynamics of hapten and antigen binding by rabbit antidinitrophenyl antibody

1975 • 34 citations

Properties of myeloma immunoglobulin E(Yu). Chemical, fluorescence polarisation and spin-labeled studies

1973 • 33 citations

Kinetic studies on antibody-hapten reactions-I

1971 • 33 citations

Electron microscopy of complexes between IgA (MOPC 315) and a bifunctional hapten

1971 • 33 citations

Partial amino-acid sequences of human and rabbit C-reactive proteins: homology with immunoglobulins and histocompatibility antigens.

1977 • 31 citations

Different degrees of interspecies homology in immunoglobulin λ chain constant domain correlated with three-dimensional structure

1975 • 31 citations

Aggregation of chicken γG immunoglobulin in 1.5 M sodium chloride solution

1966 • 31 citations

IgM Waldenstroem with specificity against phosphorylcholine

1975 • 29 citations

Increase of the rotational relaxation time of antibody molecule after complex formation with dansyl‐hapten

1972 • 28 citations

X-ray crystallographic study of the fab fragments from two human myeloma proteins

1969 • 28 citations

Immunoglobulins with multiple binding functions. II. The use of nylon-polyserine whisker discs in screening myeloma immunoglobulins for binding activity.

1974 • 27 citations

On the Structure of Antibody Active Sites

1967 • 27 citations

Determination of Antibody-Hapten Association Kinetics: A Simplified Experimental Approach

1975 • 25 citations

AFFINITY LABELING OF THE ACTIVE SITES OF ANTIBODIES and MYELOMA PROTEINS

1971 • 25 citations

Crystallographic Data for the Fab Fragment of a Human Myeloma Immunoglobulin

1968 • 25 citations

Structural basis for the association of heavy and light chains and the relation of subgroups to the conformation of the active site of immunoglobulins

1975 • 24 citations

THE AMINO ACID SEQUENCE OF HUMAN MACROGLOBULINS *

1971 • 24 citations

CORRELATIONS BETWEEN AMINO ACID SEQUENCE AND CONFORMATION OF IMMUNOGLOBULIN LIGHT CHAINS

1969 • 24 citations

The specificity of chain interactions among immunoglobulins. Combinations of γ chains with κ chains of the same subgroup as in the parent immunoglobulin G

1974 • 23 citations

Cross-Reactions between 2,4-Dinitrophenyl and Menadione (Vitamin K3) and the General Problem of Antibody Specificity

1976 • 22 citations

Structure of heavy chain from strain 13 guinea pig immunoglobulin-G(2). III. Amino acid sequence of the region around the half-cystine joining heavy and light chains

1971 • 22 citations

CORRELATIONS BETWEEN AMINO ACID SEQUENCE AND CONFORMATTON OF IMMUNOGLOBULIN LIGHT CHAINS

1969 • 20 citations

Amino acid sequence of the VH region of a human myeloma immunoglobulin (IgG New)

1977 • 19 citations

Correlations between amino acid sequence and conformation of immunoglobulin light chains. I. Hydrophobicity and fractional charge.

1969 • 19 citations

Three-dimensional Structure and Diversity of Immunoglobulins

1977 • 18 citations

Immunoglobulins with Multiple Binding Functions

1974 • 18 citations

Crystals of Fragment Fab′: Preparation from Pepsin Digests of Human IgG Myeloma Proteins

1969 • 18 citations

Crystallographic Studies of an IgG Immunoglobulin and the Bence-Jones Protein from One Patient

1972 • 18 citations

Primary Structural Differences in Myeloma Proteins That Bind the Same Haptens

1977 • 14 citations

Kinetics of binding of 2,4-dinitrophenyl and 2,4,6-trinitrophenyl haptens to homologous and heterologous rabbit antibodies

1975 • 13 citations

New books - The use of X-ray diffraction in the study of protein and nucleic acid structure

1966 • 12 citations

Phylogenesis of the general structure of immunoglobulins

1975 • 12 citations

Restricted flexibility of carp 15 S immunoglobulin molecules as revealed by fluorescence polarisation

1972 • 11 citations

Structure and specificity of antibody molecules

1975 • 11 citations

Some correlations between specificity and sequence of the first complementarity-determining segments of human kappa light chains.

1976 • 11 citations

X-Ray Crystallographic Studies of Immunoglobulins

1973 • 10 citations

A spontaneously occurring complex of beta2-microglobulin and a fragment of gamma-chain of IgG: isolation from the urine of a patient with plasma cell leukemia and characterization.

1977 • 8 citations

Folding, Association, and Interactions of Domains in the Antibody Molecule

1977 • 7 citations

A Spontaneously Occurring Complex of β2-Microglobulin and a Fragment of γ-Chain of IgG: Isolation from the Urine of a Patient with Plasma Cell Leukemia and Characterization

1977 • 5 citations

Proceedings: A model of the immunoglobulin M (IgM) molecule.

1974 • 1 citations