Genetics, Cellular Expression and Function of IgD and IgM Receptors

Gene Action in the X-chromosome of the Mouse (Mus musculus L.)

1961 • 3,881 citations

‘Actively Acquired Tolerance’ of Foreign Cells

1953 • 3,103 citations

Rapid Isolation of Antigens from Cells with A Staphylococcal Protein A-Antibody Adsorbent: Parameters of the Interaction of Antibody-Antigen Complexes with Protein A

1975 • 3,054 citations

Immunogenetic Consequences of Vascular Anastomoses Between Bovine Twins

1945 • 1,352 citations

Conjugation of antibodies with fluorochromes: Modifications to the standard methods

1976 • 757 citations

Fusion between immunoglobulin‐secreting and nonsecreting myeloma cell lines

1976 • 729 citations

Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.

1976 • 726 citations

Genes and Antibodies

1959 • 675 citations

Cell Membrane Antigen Isolation with the Staphylococcal Protein A-Antibody Adsorbent

1976 • 508 citations

THE ORGANIZATION, EXPRESSION, AND EVOLUTION OF ANTIBODY GENES AND OTHER MULTIGENE FAMILIES

1975 • 446 citations

CELLULAR LOCALIZATION OF IMMUNOGLOBULINS WITH DIFFERENT ALLOTYPIC SPECIFICITIES IN RABBIT LYMPHOID TISSUES

1965 • 444 citations

Early production of intracellular IgM by B-lymphocyte precursors in mouse

1976 • 435 citations

IgG on Lymphocyte Surfaces; Technical Problems and the Significance of a Third Cell Population

1975 • 418 citations

Membrane Immunoglobulins and Antigen Receptors on B and T Lymphocytes

1974 • 382 citations

An Improved Method for Isolation of H-2 and Ia Alloantigens with Immunoprecipitation Induced by Protein A-Bearing Staphylococci

1976 • 351 citations

Recognition by pregnancy serums of non-HL-A alloantigens selectively expressed on B lymphocytes.

1975 • 332 citations

Differentiation of lymphocytes in mouse bone marrow

1974 • 305 citations

Immunoglobulin-Receptors Revisited

1975 • 302 citations

Evidence for the clonal abortion theory of B-lymphocyte tolerance.

1975 • 293 citations

In vitro tolerance induction of neonatal murine B cells.

1976 • 281 citations

Transposable genetic elements as agents of gene instability and chromosomal rearrangements

1977 • 271 citations

THE GENETIC CONTROL OF IMMUNOGLOBULIN SYNTHESIS

1972 • 249 citations

Differences in susceptibility of mature and immature mouse B lymphocytes to anti-immunoglobulin-induced immunoglobulin suppression in vitro. Possible implications for B-cell tolerance to self.

1975 • 228 citations

RABBIT LYMPHOID CELLS DIFFERENTIATED WITH RESPECT TO α-, γ-, AND µ- HEAVY POLYPEPTIDE CHAINS AND TO ALLOTYPIC MARKERS A<scp>A</scp>1 AND A<scp>A</scp>2

1966 • 212 citations

B-lymphocyte heterogeneity: development and characterization of an alloantiserum which distinguishes B-lymphocyte differentiation alloantigens.

1977 • 212 citations

Receptor-mediated inactivation of early B lymphocytes

1975 • 187 citations

Preparation and use of Ly antisera

1975 • 182 citations

Similar Idiotypic Specificity for the Membrane IgD and IgM of Human B Lymphocytes

1975 • 179 citations

Identification of a B-cell surface structure involved in antigen-dependent triggering: absence of this structure on B cells from CBA/N mutant mice.

1977 • 178 citations

Growth of B-lymphocyte colonies in vitro.

1975 • 173 citations

PRODUCTION OF ANTIBODIES

1950 • 171 citations

Candidate for immunoglobulin D present on murine B lymphocytes

1974 • 170 citations

Inherited Immunoglobulin Idiotypes of the Mouse

1977 • 168 citations

Studies on the Generation of B Lymphocytes in Fetal Liver and Bone Marrow

1977 • 150 citations

Differentiation of lymphocytes in mouse bone marrow

1974 • 141 citations

Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell.

1975 • 139 citations

H-2-LINKED IMMUNE RESPONSE (Ir) GENES

1972 • 132 citations

GENETIC CORRELATION OF A MOUSE LIGHT CHAIN VARIABLE REGION MARKER WITH A THYMOCYTE SURFACE ANTIGEN

1974 • 130 citations

Same Idiotypc of B‐Lymphocyte Membrane IgD and IgM. Formal Evidence for Monoclonality of Chronic Lymphocytic Leukemia Cells

1974 • 127 citations

New genetic model for allelism at histocompatibility and other complex loci: polymorphism for control of gene expression.

1973 • 126 citations

Sequence analysis of immunoglobulin light chain messenger RNA

1974 • 123 citations

Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance.

1976 • 123 citations

Reiteration frequency of immunoglobulin light chain genes: further evidence for somatic generation of antibody diversity.

1976 • 119 citations

Genetic control of antibody specificity in the mouse

1975 • 116 citations

X-linked B-lymphocyte defect in CBA/N mice. III. Abnormal development of B-lymphocyte populations defined by their density of surface immunoglobulin.

1976 • 115 citations

Studies on the differentiation of B lymphocytes in the mouse.

1973 • 113 citations

Independent Movement of IgD and IgM Molecules on the Surface of Individual Lymphocytes

1973 • 112 citations

Antigen-induced co-capping of IgM and IgD-like receptors on murine B cells.

1976 • 108 citations

Demonstration that IgG memory is carried by IgG‐bearing cells

1976 • 108 citations

Surface immunoglobulins of lipopolysaccharide‐stimulated spleen cells The behaviour of IgM, IgD and IgG

1977 • 92 citations

Defective colony formation by B lymphocytes from CBA/N and C3H/HeJ mice.

1977 • 89 citations

Single cell studies on the antibody-forming potential of fractionated, hapten-specific B lymphocytes.

1976 • 87 citations

B-cell tolerance. III. Effect of papain-mediated cleavage of cell surface IgD on tolerance susceptibility of murine B cells.

1977 • 84 citations

Adenovirus amazes at Cold Spring Harbor

1977 • 83 citations

B-lymphocyte heterogeneity: ontogenetic development and organ distribution of B-lymphocyte populations defined by their density of surface immunoglobulin.

1976 • 83 citations

Preparation and characterisation of an antiserum to the mouse candidate for immunoglobulin D

1976 • 71 citations

B-cell tolerance. II. Trinitrophenyl human gamma globulin-induced tolerance in adult and neonatal murine B cells responsive to thymus- dependent and independent forms of the same hapten

1977 • 70 citations

Immunoglobulin Allotypes

1973 • 69 citations

The relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes II. Surface immunoglobulin isotopes on unprimed B cells in the spleen.

1977 • 69 citations

Biochemical and Biological Characteristics of Lymphocyte Surface Immunoglobulin

1973 • 66 citations

The relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes. I. Surface immunoglobulin isotypes on primed B cells in the spleen.

1977 • 66 citations

THE APPLICATIONS OF GENETIC MOSAICISM TO DEVELOPMENTAL PROBLEMS

1971 • 64 citations

Thoracic duct lymphocytes from nude mice: Migratory properties and life‐span

1972 • 64 citations

Genetic polymorphism of IgD-like cell surface immunoglobulin in the mouse.

1976 • 62 citations

Loss of surface IgD by human B lymphocytes during polyclonal activation^*

1977 • 61 citations

The Biological Origin of Antibody Diversity

1976 • 59 citations

Genetics of the idotype of BALB/c myeloma S117: multiple chromosomal loci for Vh genes encoding specificity for group A streptococcal carbohydrate.

1976 • 59 citations

Immunoglobulin allotypes of rabbit kappa chains: polymorphism of a control mechanism regulating closely linked duplicated genes?

1976 • 54 citations

Immunoglobulin determinants on the lymphocytes of normal rabbits. 3. As4 and As6 determinants on individual lymphocytes and the concept of allelic exclusion.

1971 • 52 citations

[Immunological aspects of neoplasia].

1975 • 52 citations

Preliminary Amino Acid Sequences of Transplantation Antigens: Genetic and Evolutionary Implications

1976 • 52 citations

Mouse immunoglobulin receptors on lymphocytes: identification of IgM and IgD molecules by tryptic cleavage and a postulated role for cell surface IgD

1977 • 51 citations

Anti-immunoglobulin stimulation of murine lymphocytes. II. Identification of cell surface target molecules and requirements for cross-linkage.

1976 • 50 citations

Structure and regulation of immunoglobulins: kappa allotypes in the rat have multiple amino-acid differences in the constant region.

1975 • 49 citations

The class of surface immunoglobulin on cells carrying IgG memory in rat thoracic duct lymph: the size of the subpopulation mediating IgG memory.

1976 • 49 citations

Cell Membrane IgD: Demonstration of IgD on Human Lymphocytes by Enzyme-Catalyzed Iodination and Comparison with Cell Surface Ig of Mouse, Guinea Pig, and Rabbit

1976 • 47 citations

Antibody differentiation: apparent sequence identity between variable regions shared by IgA and IgG immunoglobulins.

1976 • 43 citations

Ontogeny of mouse B lymphocytes and inactivation by antigen of early B lymphocytes.

1976 • 41 citations

Tolerance induction in maturing B cells.

1977 • 40 citations

The Generation of Antibody Diversity: A New Look

1977 • 39 citations

Measurement and comparison of the proliferative and antibody responses of neonatal, immature and adult murine spleen cells to T-dependent and T-independent antigens

1976 • 39 citations

Genetics of the immunoglobulin variable region

1974 • 39 citations

Partial characterisation of Ia antigens on murine thymocytes

1975 • 34 citations

Antifluorescein affinity columns. Isolation and immunocompetence of lymphocytes that bind fluoresceinated antigens in vivo or in vitro.

1976 • 33 citations

Cell Surface Immunoglobulin. XIII. Distribution of IgM and IgD-Like Molecules on Small and Large Cells of Mouse Spleen

1975 • 32 citations

Sites of “Spontaneous” Degradation of IgD

1977 • 31 citations

Differentiation of lymphocytes in the mouse bone marrow. III. The adoptive response of bone marrow cells to a thymus cell-independent antigen.

1974 • 31 citations

Immunoglobulins M and D as antigen‐binding receptors on the same cell, with shared specificity

1976 • 30 citations

Allotypes of IgM and IgD Receptors in the Mouse: A Probe for Lymphocyte Differentiation

1978 • 29 citations

Cell surface immunoglobulin. XIX. Susceptibility of IgD and IgM on murine splenocytes to cleavage by papain.

1976 • 29 citations

Membrane Ig on human lymphocytes: rate of turnover of IgD and IgM on the surface of human tonsil cells

1976 • 29 citations

Antibody Diversity: Is it All Coded for by the Germ Line 206

1973 • 27 citations

Tolerance in differentiating B lymphocytes

1977 • 26 citations

Use and abuse of sepharose-conjugated antibodies for the isolation of lymphocyte-surface immunoglobulins

1976 • 26 citations

Cell surface immunoglobulin. XV. The presence of IgM and an IgD-like molecule on the same cell in murine lymphoid tissue

1976 • 25 citations

Surface immunoglobulin on rabbit lymphoid cells

1976 • 24 citations

Allotypes of mouse IgM immunoglobulin

1977 • 23 citations

Estimation of hapten-specific antibody-forming cell precursors in microcultures.

1976 • 22 citations

IgM-IgG switch-over among antibody-forming cells in the mouse

1977 • 19 citations

Allotypic suppression of adult mouse spleen cells: Cell differentiation, class restriction and allotypic exclusion

1972 • 18 citations

The expression of immunoglobulin determinants on the surface of antigen‐binding lymphoid cells in mice. II. Allotypes of the lg‐1 locus

1971 • 18 citations

Genetic regulation of the antibody response to H-2Db alloantigens in mice. III. Inhibition of the IgG Response to noncongenic cells by preimmunization with congenic cells.

1976 • 17 citations

Hapten-specific B Lymphocytes: Enrichment, Cloning, Receptor Analysis, and Tolerance Induction

1977 • 15 citations

Demonstration of double allelic expression (allelic inclusion) of rabbit κ light chain allotypes on heterozygous lymphocytes by double allotype sequential stimulation

1977 • 14 citations

Spontaneous AKR lymphoma with T and B-cell characteristics

1975 • 13 citations

Functional maturation of B cells in vitro.

1977 • 9 citations

Pathways to immunological tolerance: an approach through the study of maturing B lymphocytes.

1976 • 8 citations

Protective Effect of orally administered S,β-Aminoethylisothiuronium.Br.HBr against X-radiation Death in Mice

1961 • 5 citations

HEAVY CHAINS OF MURINE SPLENOCYTE MEMBRANE IMMUNOGLOBULINS: A COMPARISON WITH THE HEAVY CHAINS OF HUMAN AND TOAD SERUM IMMUNOGLOBULINS

1976 • 4 citations