Effects of γ-interferon on major histocompatibility complex antigen expression and lymphocytic infiltration in the 9L gliosarcoma brain tumor model: implications for strategies of immunotherapy

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.

1983 • 1,918 citations

A cell-surface molecule involved in organ-specific homing of lymphocytes

1983 • 1,515 citations

Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.

1982 • 754 citations

Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells

1987 • 648 citations

Abrogation of metastatic properties of tumour cells by de novo expression of H–2K antigens following H–2 gene transfection

1985 • 410 citations

Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation

1984 • 359 citations

Transforming growth factor-beta 1 modulates the expression of class II histocompatibility antigens on human cells.

1988 • 298 citations

Striking paucity of HLA-A, B, C and beta 2-microglobulin on human neuroblastoma cell lines.

1983 • 257 citations

Intrathecal application of interferon gamma. Progressive appearance of MHC antigens within the rat nervous system.

1990 • 240 citations

American Association of Pathologists president's address. New roles for the endothelium in inflammation and immunity.

1987 • 232 citations

Role of the Major Histocompatibility Complex Class I Antigens in Tumor Growth and Metastasis

1988 • 201 citations

Morphological studies of rat brain tumors induced by N-nitrosomethylurea

1971 • 175 citations

Molecular bases of the immune response to neural antigens

1987 • 156 citations

Immune‐Mediated Encephalitis: On the Role of Antigen‐Presenting Cells in Brain Tissue

1987 • 155 citations

Norepinephrine inhibits gamma-interferon-induced major histocompatibility class II (Ia) antigen expression on cultured astrocytes via beta-2-adrenergic signal transduction mechanisms.

1988 • 142 citations

Immune modulation within the brain: recruitment of inflammatory cells and increased major histocompatibility antigen expression following intracerebral injection of interferon-γ

1991 • 136 citations

Lymphocyte migration into brain modelled in vitro: Control by lymphocyte activation, cytokines, and antigen

1990 • 126 citations

Adhesion of lymphocytes to cerebral microvascular cells: effects of interferon-gamma, tumour necrosis factor and interleukin-1.

1988 • 119 citations

Antigen presentation in brain: MHC induction on brain endothelium and astrocytes compared.

1987 • 115 citations

Transforming growth factor‐β2 down‐regulates HLA‐DR antigen expression on human malignant glioma cells.

1988 • 110 citations

Rat ependyma and microglia cells express class II MHC antigens after intravenous infusion of recombinant gamma interferon

1988 • 101 citations

Modulation of murine tumor major histocompatibility antigens by cytokines in vivo and in vitro.

1988 • 101 citations

Immunotherapy of a murine tumor with interleukin 2. Increased sensitivity after MHC class I gene transfection.

1987 • 94 citations

Immunohistochemical studies of adult human glial cells

1989 • 89 citations

Expression of major histocompatibility complex class I antigens as a strategy for the potentiation of immune recognition of tumor cells.

1986 • 87 citations

BCNU and X-ray therapy of intracerebral 9L rat tumors

1979 • 74 citations

Response of glioma cells to interferon‐gamma: increase in class II RNA, protein and mixed lymphocyte reaction‐stimulating ability

1985 • 70 citations

Radiation therapy of 9L rat brain tumors

1981 • 52 citations

Specific uptake of the auger electron-emitting thymidine analogue 5-[123I/125I]iodo-2'-deoxyuridine in rat brain tumors: diagnostic and therapeutic implications in humans.

1990 • 45 citations

IFN-treated neuroblastoma cell lines remain resistant to T cell-mediated allo-killing, and susceptible to non-MHC-restricted cytotoxicity.

1988 • 43 citations

Response of a rat brain tumor to fractionated therapy with low doses of BCNU and irradiation

1979 • 40 citations

Kinetics of MHC gene expression and mRNA synthesis in brain endothelium.

1988 • 36 citations

Phenotyping of 60 cultured human gliomas and 34 other neuroectodermal tumors by means of monoclonal antibodies against glioma, melanoma and HLA-DR antigens

1985 • 32 citations

Heterogeneity of the Induction of HLA-DR Expression by Human Immune Interferon on Glioma Cell Lines and Their Clones<xref ref-type="fn" rid="FN2">2</xref>

1986 • 32 citations

Rationale for Recombinant Human Interferon-Gamma Adjuvant Immunotherapy for Cancer

1988 • 25 citations

Interferon-mediated in vivo induction of β2-microglobulin on small-cell lung cancers and mid-gut carcinoids

1986 • 23 citations

Single agent therapy of interferon for brain tumours: Correlation between natural killer activity and clinical course

1984 • 21 citations

The effects of irradiation on major histocampatibility complex expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model

1990 • 15 citations

Effect of in vivo administration of interferon gamma on expression of MHC products and tumour associated antigens in patients with metastatic melanoma

1989 • 14 citations

MHC regulation in neural cells. Distribution of peripheral and internal beta 2-microglobulin and class I molecules in human neuroblastoma cell lines.

1990 • 14 citations

Treatment of an intracerebral rat brain tumor with Corynebacterium parvum and radiation.

1977 • 4 citations