Extrathymic T-cell selection

The Staphylococcal Enterotoxins and Their Relatives

1990 • 1,914 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

1991 • 675 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation.

1991 • 599 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

1988 • 476 citations

Effect of neonatal thymectomy on the immunological responsiveness of the mouse

1962 • 375 citations

Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo

1989 • 351 citations

The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation.

1991 • 345 citations

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1988 • 343 citations

Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway.

1991 • 298 citations

Induction of tolerance in peripheral T cells with monoclonal antibodies

1990 • 285 citations

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

1987 • 269 citations

Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells

1988 • 266 citations

Peripheral Clonal Elimination of Functional T Cells

1990 • 213 citations

The induction of skin graft tolerance in major histocompatibility complex‐mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti‐CD4 and anti‐CD8 antibodies

1990 • 157 citations

An unusual lineage of alpha/beta T cells that contains autoreactive cells.

1991 • 152 citations

The appearance of T cells bearing self-reactive T cell receptor in the livers of mice injected with bacteria.

1991 • 145 citations

Non‐Deletional Mechanisms of Peripheral and Central Tolerance: Studies with Transgenic Mice with Tissue‐Specific Expression of a Foreign MHC Class I Antigen

1991 • 107 citations

Expression in transgenic mice of class I histocompatibility antigens controlled by the metallothionein promoter.

1989 • 104 citations

Peripheral tolerance to allogeneic class II histocompatibility antigens expressed in transgenic mice: evidence against a clonal-deletion mechanism.

1989 • 91 citations

T cell antigen receptor expression in athymic (nu/nu) mice. Evidence for an oligoclonal beta chain repertoire.

1987 • 81 citations

The expression of influenza virus hemagglutinin in the pancreatic β cells of transgenic mice results in autoimmune diabetes

1990 • 79 citations

Peripheral Tolerance in Transgenic Mice: Tolerance to Class II MHC and non‐MHC Transgene Antigens

1991 • 38 citations

Experimental thymology has come of age.

1979 • 30 citations

THE INFLUENCE OF INTERLEUKIN 2 ON THE PERSISTENCE OF TOLERANCE

1988 • 4 citations