Telomerase: A Target for Anticancer Therapy

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

A survey of telomerase activity in human cancer

1997 • 2,747 citations

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1997 • 2,256 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

1997 • 1,786 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

Origin of Concatemeric T7DNA

1972 • 1,591 citations

Telomerase activity in human germline and embryonic tissues and cells

1996 • 1,345 citations

Telomere loss: mitotic clock or genetic time bomb?

1991 • 1,144 citations

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

1997 • 946 citations

Structure and variability of human chromosome ends.

1990 • 833 citations

Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound

1997 • 768 citations

Telomerase activity in normal and malignant hematopoietic cells.

1995 • 748 citations

A role for both RB and p53 in the regulation of human cellular senescence*1

1991 • 737 citations

Telomerase activity in normal leukocytes and in hematologic malignancies

1995 • 619 citations

Isolation of a Candidate Human Telomerase Catalytic Subunit Gene, Which Reveals Complex Splicing Patterns in Different Cell Types

1997 • 586 citations

[Principle of marginotomy in template synthesis of polynucleotides].

1971 • 566 citations

Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

1995 • 552 citations

Sugar and Disease

1972 • 532 citations

Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts.

1989 • 481 citations

Cationic Porphyrins as Telomerase Inhibitors: the Interaction of Tetra-(N-methyl-4-pyridyl)porphine with Quadruplex DNA

1998 • 422 citations

Controlling Gene Expression in Living Cells Through Small Molecule-RNA Interactions

1998 • 415 citations

NMR-Based Model of a Telomerase-Inhibiting Compound Bound to G-Quadruplex DNA

1998 • 359 citations

Inhibition of human telomerase activity by peptide nucleic acids

1996 • 342 citations

Effects of Reverse Transcriptase Inhibitors on Telomere Length and Telomerase Activity in Two Immortalized Human Cell Lines

1996 • 337 citations

Detection of Telomerase Activity in Malignant and Nonmalignant Skin Conditions

1996 • 274 citations

Differentiation of immortal cells inhibits telomerase activity.

1995 • 269 citations

Telomerase Inhibition, Telomere Shortening, and Senescence of Cancer Cells by Tea Catechins

1998 • 246 citations

Cell cycle-dependent modulation of telomerase activity in tumor cells.

1996 • 226 citations

Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands

1998 • 218 citations

Telomerase activity in human intestine

1996 • 207 citations

Protein Phosphatase 2A Inhibits Nuclear Telomerase Activity in Human Breast Cancer Cells

1997 • 197 citations

Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA

1998 • 188 citations

Antisense telomerase treatment: induction of two distinct pathways, apoptosis and differentiation

1998 • 171 citations

Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition

1997 • 160 citations

Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids.

1996 • 156 citations

1,4- and 2,6-Disubstituted Amidoanthracene-9,10-dione Derivatives as Inhibitors of Human Telomerase

1998 • 155 citations

Inhibition of human telomerase by 2′- O -methyl-RNA

1998 • 139 citations

Inhibition of Telomerase Activity by PKC Inhibitors in Human Nasopharyngeal Cancer Cells in Culture

1997 • 138 citations

Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines.

1996 • 127 citations

Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3

1995 • 125 citations

Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by 3'-azido-3'-deoxythymidine.

1998 • 111 citations

Hammerhead Ribozyme-Mediated Inhibition of Telomerase Activity in Extracts of Human Hepatocellular Carcinoma Cells

1996 • 95 citations

Down-regulation of Telomerase Activity Is an Early Event in the Differentiation of HL60 Cells

1996 • 81 citations

A Hexameric Phosphorothioate Oligonucleotide Telomerase Inhibitor Arrests Growth of Burkitt's Lymphoma Cellsin Vitroandin Vivo

1997 • 76 citations

Supression of telomerase activity in HL60 cells after treatment with differentiating agents.

1996 • 72 citations

Reverse transcriptase inhibitors suppress telomerase function and induce senescence‐like processes in cultured mouse fibroblasts

1996 • 72 citations

Human Telomerase Inhibition by 7-Deaza-2‘-deoxypurine Nucleoside Triphosphates

1996 • 63 citations

Preclinical and clinical strategies for development of telomerase and telomere inhibitors

1997 • 61 citations

Synthetic 2′-O-Mrthyl-Modified Hammerhead Ribozymes Targeted to the RNA Component of Telomerase as Sequence-Specific Inhibitors of Telomerase Activity

1998 • 41 citations

Rare mutations in a domain crucial for V3-loopstructure prevail in replicating HIV from long-term non-progressors

1998 • 39 citations

Growth arrest of immortalized human keratinocytes and suppression of telomerase activity byp21WAF1 gene expression

1998 • 36 citations

Identification of a series of potent telomerase inhibitors using a time-resolved fluorescence-based assay

1998 • 14 citations

Effect of prostaglandin A1 on proliferation and telomerase activity of human melanoma cells in vitro

1998 • 12 citations