Inhibition of human telomerase by 2′- O -methyl-RNA

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

A survey of telomerase activity in human cancer

1997 • 2,747 citations

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1997 • 2,256 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

1997 • 2,086 citations

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

1997 • 1,786 citations

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

1989 • 1,509 citations

Telomere elongation in immortal human cells without detectable telomerase activity.

1995 • 1,249 citations

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1997 • 1,244 citations

Telomerase activity in normal and malignant hematopoietic cells.

1995 • 748 citations

Evaluation of 2‘-modified oligonucleotides containing 2‘-deoxy gaps as antisense inhibitors of gene expression

1993 • 734 citations

TLC1 : Template RNA Component of Saccharomyces cerevisiae Telomerase

1994 • 727 citations

Correlating telomerase activity levels with human neuroblastoma outcomes

1995 • 631 citations

2′-O-(2-Methoxy)ethyl-modified Anti-intercellular Adhesion Molecule 1 (ICAM-1) Oligonucleotides Selectively Increase the ICAM-1 mRNA Level and Inhibit Formation of the ICAM-1 Translation Initiation Complex in Human Umbilical Vein Endothelial Cells

1997 • 366 citations

Inhibition of human telomerase activity by peptide nucleic acids

1996 • 342 citations

Runaway telomere elongation caused by telomerase RNA gene mutations

1995 • 338 citations

Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhang.

1996 • 261 citations

A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA.

1996 • 255 citations

Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase.

1996 • 226 citations

Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: In vitro and in vivo studies

1997 • 225 citations

In vivo studies with antisense oligonucleotides

1997 • 193 citations

Stringent sequence requirements for the formation of human telomeres.

1994 • 190 citations

Clinical implications of telomerase in cancer

1997 • 186 citations

Refining the telomere-telomerase hypothesis of aging and cancer

1996 • 170 citations

Nuclease Resistance and Antisense Activity of Modified Oligonucleotides Targeted to Ha-

1996 • 161 citations

Comparison of the telomeric repeat amplification protocol (TRAP) to the new TRAP-eze telomerase detection kit

1996 • 135 citations

Antisense oligonucleotides: Is the glass half full or half empty?

1998 • 113 citations

Peptide nucleic acids: Expanding the scope of nucleic acid recognition

1997 • 110 citations

Synthesis and Characterization of a Peptide Nucleic Acid Conjugated to a <scp>d</scp>-Peptide Analog of Insulin-like Growth Factor 1 for Increased Cellular Uptake

1997 • 106 citations

Synthesis and membrane permeability of PNA-peptide conjugates

1997 • 99 citations

Identification of Determinants for Inhibitor Binding within the RNA Active Site of Human Telomerase Using PNA Scanning

1997 • 89 citations

Enhancement of strand invasion by oligonucleotides through manipulation of backbone charge

1996 • 70 citations

Cancer and the knockout mouse

1997 • 43 citations

Short Communication

1996 • 42 citations

Targeting peptide nucleic acid-protein conjugates to structural features within duplex DNA

1995 • 38 citations

Hybrid oligonucleotides: Synthesis, biophysical properties, stability studies, and biological activity

1996 • 30 citations

Telomerase: anti-cancer target or just a fascinating enzyme?

1996 • 22 citations