Identification of a series of potent telomerase inhibitors using a time-resolved fluorescence-based assay

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

Europium as a label in time-resolved immunofluorometric assays

1984 • 865 citations

Telomerase activity in normal leukocytes and in hematologic malignancies

1995 • 619 citations

Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity

1995 • 490 citations

Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes

1994 • 360 citations

Effects of Reverse Transcriptase Inhibitors on Telomere Length and Telomerase Activity in Two Immortalized Human Cell Lines

1996 • 337 citations

Telomeres, Telomerase and Cancer

1996 • 308 citations

Inhibitors of HIV Nucleocapsid Protein Zinc Fingers as Candidates for the Treatment of AIDS

1995 • 228 citations

Refining the telomere-telomerase hypothesis of aging and cancer

1996 • 170 citations

Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids.

1996 • 156 citations

Chemical reactivity of some isothiazolone biocides

1990 • 132 citations

Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?

1995 • 121 citations

Biophysical Characterization of Zinc Ejection from HIV Nucleocapsid Protein by Anti-HIV 2,2‘-Dithiobis[benzamides] and Benzisothiazolones

1996 • 86 citations

Telomeres and telomerase in human leukemias.

1996 • 79 citations

Do telomerase antagonists represent a novel anti-cancer strategy?

1996 • 63 citations

Telomerase activity and oncogenesis in giant cell tumor of bone

1995 • 63 citations

Detection of telomerase activity by combination of TRAP method and scintillation proximity assay (SPA)

1996 • 59 citations

Covalent modification of the interleukin‐5 receptor by isothiazolones leads to inhibition of the binding of interleukin‐5

1994 • 48 citations

High capacity screening of pooled compounds: Identification of the active compound without re-assay of pool members

1996 • 31 citations

Europium-Labeled Oligonucleotide Hybridization Probes: Preparation and Properties

1994 • 20 citations

Heteroaryl-Fused 2-Phenylisothiazolone Inhibitors of Cartilage Breakdown

1994 • 18 citations

Metabolism resistant isothiazolone inhibitors of cartilage breakdown

1995 • 11 citations

Detection of amplified HTLV-I/-II viral sequences using time-resolved fluorometry

1992 • 11 citations