Forefronts in Nephrology: Summary of the Newer Aspects of Renal Cell Injury

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

Homologous plant and bacterial proteins chaperone oligomeric protein assembly

1988 • 1,316 citations

Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

1990 • 1,293 citations

70K heat shock related proteins stimulate protein translocation into microsomes

1988 • 1,276 citations

A Role for a 70-Kilodalton Heat Shock Protein in Lysosomal Degradation of Intracellular Proteins

1989 • 932 citations

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

1990 • 756 citations

Stress proteins in biology and medicine

1990 • 731 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

Calcium pump of the plasma membrane

1991 • 659 citations

Induced thermal resistance in HeLa cells

1975 • 494 citations

Ankyrin binding to (Na+ + K+)ATPase and implications for the organization of membrane domains in polarized cells

1987 • 470 citations

Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity

1990 • 444 citations

Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast.

1990 • 435 citations

Biochemical characterization of the mammalian stress proteins and identification of two stress proteins as glucose- and Ca2+-ionophore-regulated proteins.

1983 • 431 citations

Inflammation and Oxidative Stress in Carcinogenesis

1993 • 419 citations

Identity of the 19S 'prosome' particle with the large multifunctional protease complex of mammalian cells (the proteasome)

1988 • 404 citations

Epidermal growth factor enhances renal tubule cell regeneration and repair and accelerates the recovery of renal function in postischemic acute renal failure.

1989 • 400 citations

Rapid purification of mammalian 70,000-dalton stress proteins: affinity of the proteins for nucleotides.

1985 • 365 citations

The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins.

1990 • 327 citations

IMPORTANT COMPONENTS OF THE UW SOLUTION

1990 • 302 citations

Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy.

1990 • 294 citations

Cytoprotective effects of glycine and glutathione against hypoxic injury to renal tubules.

1987 • 274 citations

Stress proteins in biology and medicine

1990 • 273 citations

Acute renal failure with selective medullary injury in the rat.

1988 • 262 citations

Mechanism of calcium potentiation of oxygen free radical injury to renal mitochondria. A model for post-ischemic and toxic mitochondrial damage.

1986 • 258 citations

Dynamics of membrane-skeleton (fodrin) organization during development of polarity in Madin-Darby canine kidney epithelial cells.

1986 • 247 citations

The plasma membrane Ca2+ pump contains a site that interacts with its calmodulin-binding domain.

1991 • 206 citations

The role of calcium in cell killing

1990 • 199 citations

Effects of metabolic acidosis on viability of cells exposed to anoxia

1985 • 179 citations

Modulation of fodrin (membrane skeleton) stability by cell-cell contact in Madin-Darby canine kidney epithelial cells.

1987 • 178 citations

Purification of a high-molecular-mass form of phospholipase A2 from rat kidney activated at physiological calcium concentrations

1990 • 174 citations

Activation of the heat shock transcription factor by hypoxia in mammalian cells.

1990 • 173 citations

Oxidative injury and the heat shock response

1990 • 172 citations

Glutathione uptake and protection against oxidative injury in isolated kidney cells

1988 • 152 citations

Characterization of phospholipase A2 (PLA2) activity in gerbil brain: enhanced activities of cytosolic, mitochondrial, and microsomal forms after ischemia and reperfusion

1991 • 151 citations

Dissociation and redistribution of Na+,K(+)-ATPase from its surface membrane actin cytoskeletal complex during cellular ATP depletion.

1991 • 147 citations

Improved function with amino acids in the isolated perfused kidney

1982 • 133 citations

Epidermal growth factor accelerates renal repair in mercuric chloride nephrotoxicity

1990 • 123 citations

CHRONIC CYCLOSPORINE-INDUCED NEPHROPATHY IN THE RAT

1990 • 119 citations

Erythrophagocytosis induces heat shock protein synthesis by human monocytes-macrophages.

1990 • 118 citations

Alterations in the establishment and maintenance of epithelial cell polarity as a basis for disease processes.

1990 • 116 citations

Protein kinase C activity in the rat hippocampus after forebrain ischemia: autoradiographic analysis by [3H]phorbol 12,13-dibutyrate

1989 • 116 citations

Subcellular characteristics of phospholipase A2 activity in the rat kidney. Enhanced cytosolic, mitochondrial, and microsomal phospholipase A2 enzymatic activity after renal ischemia and reperfusion.

1991 • 115 citations

The calmodulin-binding domain mediates the self-association of the plasma membrane Ca2+ pump.

1991 • 113 citations

Induction, prevention and mechanisms of contrast media-induced acute renal failure

1988 • 104 citations

Calcium dependency of prostaglandin E2 production in rat glomerular mesangial cells. Evidence that protein kinase C modulates the Ca2+-dependent activation of phospholipase A2.

1988 • 103 citations

Intracellular glutathione in the protection from anoxic injury in renal proximal tubules.

1990 • 90 citations

Effects of transforming growth factor-beta, transforming growth factor-alpha, and other growth factors on renal proximal tubule cells.

1991 • 88 citations

Role of increased cytosolic free calcium in the pathogenesis of rabbit proximal tubule cell injury and protection by glycine or acidosis.

1991 • 87 citations

Cytosolic ionized calcium and bleb formation after acute cell injury of cultured rabbit renal tubule cells.

1989 • 85 citations

Histochemical and Immunohistochemical Techniques

1991 • 84 citations

Structural requirements for protection by small amino acids against hypoxic injury in kidney proximal tubules ¹

1990 • 81 citations

Gentamicin and gram-negative bacteremia. A synergism for the development of experimental nephrotoxic acute renal failure.

1986 • 79 citations

The two mammalian mitochondrial stress proteins, grp 75 and hsp 58, transiently interact with newly synthesized mitochondrial proteins.

1991 • 75 citations

The Pathophysiological Implications of Medullary Hypoxia

1989 • 72 citations

Fibroblasts of rabbit kidney in culture. II. Paracrine stimulation of papillary fibroblasts by PDGF

1991 • 70 citations

Relationship between cell adenosine triphosphate and glutathione content and protection by glycine against hypoxic proximal tubule cell injury.

1989 • 68 citations

Heat Shock Proteins and Inflammation

1991 • 64 citations

Alterations in renal structure and function in a rat model of cyclosporine nephrotoxicity.

1987 • 63 citations

Protection by glycine of proximal tubules from injury due to inhibitors of mitochondrial ATP production

1990 • 58 citations

Ischemia‐Induced Alterations in Lipid Metabolism of the Gerbil Cerebral Cortex: I. Changes in Free Fatty Acid Liberation

1990 • 56 citations

Mechanisms of perfused kidney cytoprotection by alanine and glycine

1990 • 55 citations

Fibroblasts of rabbit kidney in culture. I. Characterization and identification of cell-specific markers

1991 • 53 citations

Relationships between intracellular amino acid levels and protection against injury to isolated proximal tubules

1991 • 52 citations

Protective action of glycine in cisplatin nephrotoxicity

1991 • 49 citations

Cytosolic Ca2+ deregulation and blebbing after HgCl2 injury to cultured rabbit proximal tubule cells as determined by digital imaging microscopy.

1991 • 48 citations

Glycine prevention of cold ischemic injury in isolated hepatocytes

1991 • 48 citations

Ouabain-induced lethal proximal tubule cell injury is prevented by glycine

1990 • 43 citations

Gentamicin nephrotoxicity in the setting of acute renal hypoperfusion

1988 • 41 citations

Localization of phospholipase A2 in normal and ras-transformed cells.

1988 • 41 citations

Amino acid protection of cultured kidney tubule cells against calcium ionophore-induced lethal cell injury.

1991 • 40 citations

Alanine protects rabbit proximal tubules against anoxic injury in vitro

1990 • 39 citations

Oxidative Injury Induces Influx-Dependent Changes in Intracellular Calcium Homeostasis

1991 • 38 citations

Effect of glycine on medullary thick ascending limb injury in perfused kidneys

1991 • 37 citations

Role of cytosolic Ca in renal tubule damage induced by anoxia

1991 • 34 citations

Cyanide toxicity in hepatocytes under aerobic and anaerobic conditions

1989 • 34 citations

Metabolic aspects of protection by glycine against hypoxic injury to isolated proximal tubules.

1991 • 32 citations

Biochemical and functional discrimination of platelet-derived growth factor alpha and beta receptors in BALB/c-3T3 cells

1991 • 29 citations

Elemental microanalysis of organelles in proximal tubules. II. Effects of oxygen deprivation.

1991 • 29 citations

Integration of New Embryonic Nephrons Into the Kidney

1991 • 25 citations

Identification and primary structure of calmodulin binding domains in the phosphorylase kinase holoenzyme.

1991 • 24 citations

Primary response gene expression in renal hypertrophy and hyperplasia: evidence for different growth initiation processes

1991 • 23 citations

A focus of tissue necrosis increases renal susceptibility to gentamicin administration

1988 • 19 citations

Elemental microanalysis of organelles in proximal tubules. I. Alterations in transport and metabolism.

1991 • 16 citations

Cell activation and signal initiation: Receptor and phospholipase control of inositol phosphate, PAF and eicosanoid production

1988 • 14 citations

Aberrant Cell Growth in the Genesis of and Recovery From Renal Diseases

1991 • 5 citations

Relation Between Toxicity and Carcinogenesis in the Kidney: an Heuristic Hypothesis

1990 • 5 citations

Diversity in expression of heterozygous familial hypercholesterolemia. Characterization of a unique kindred.

1986 • 4 citations

Amino acids and metal ions protect endothelial cells from lethal injury

1991 • 4 citations

The Measurement of Free Calcium to Assess Cellular Function and Injury Using Digital Imaging Fluorescence Microscopy

1991 • 1 citations