The Measurement of Free Calcium to Assess Cellular Function and Injury Using Digital Imaging Fluorescence Microscopy

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Calcium regulation of growth and differentiation of mouse epidermal cells in culture

1980 • 1,810 citations

Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices.

1980 • 1,759 citations

Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices.

1980 • 1,043 citations

Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths

1985 • 660 citations

Changes of free calcium levels with stages of the cell division cycle

1985 • 591 citations

Calcium Rises Abruptly and Briefly Throughout the Cell at the Onset of Anaphase

1986 • 541 citations

Chapter 5 Fluorescent Indicators of Ion Concentrations

1989 • 414 citations

Spatially Resolved Calcium Dynamics of Mammalian Purkinje Cells in Cerebellar Slice

1988 • 393 citations

Calcium regulation of cell-cell contact and differentiation of epidermal cells in culture *1An ultrastructural study

1983 • 370 citations

Cellular and Subcellular Heterogeneity of [Ca ²⁺ ] _i in Single Heart Cells Revealed by Fura-2

1987 • 345 citations

Video Microscopy

1986 • 334 citations

A Ca2+-insensitive form of fura-2 associated with polymorphonuclear leukocytes. Assessment and accurate Ca2+ measurement.

1987 • 317 citations

Fluorescence ratio imaging microscopy: temporal and spatial measurements of cytoplasmic pH

1987 • 302 citations

The Role of Croton Oil Applications, Associated with a Single Painting of a Carcinogen, in Tumour Induction of the Mouse's Skin

1947 • 298 citations

Divergent responses in epidermal basal cells exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.

1982 • 237 citations

Regulated expression of differentiation-associated keratins in cultured epidermal cells detected by monospecific antibodies to unique peptides of mouse epidermal keratins

1987 • 187 citations

Chapter 6 Fluorescence Ratio Imaging Microscopy

1989 • 178 citations

Fluorescence Digital Imaging Microscopy in Cell Biology

1985 • 172 citations

Intracellular calcium alterations in response to increased external calcium in normal and neoplastic keratinocytes

1989 • 136 citations

Expression and assembly of functional bacterial luciferase in plants

1987 • 135 citations

New Observations on Cell Architecture and Dynamics by Video-Enhanced Contrast Optical Microscopy

1985 • 134 citations

The relationship between cellular ion deregulation and acute and chronic toxicity

1989 • 114 citations

Effects of ischemia-like conditions on cultured neurons: protection by low Na+, low Ca2+ solutions

1986 • 107 citations

Cytosolic ionized calcium and bleb formation after acute cell injury of cultured rabbit renal tubule cells.

1989 • 85 citations

HgCl2-induced changes in cytosolic Ca2+ of cultured rabbit renal tubular cells

1987 • 84 citations

Metabolic Imaging in Microregions of Tumors and Normal Tissues With Bioluminescence and Photon Counting

1988 • 83 citations

Simultaneous measurement of calcium transients and motion in cultured heart cells

1987 • 64 citations

Differential effects of 12-O-tetradecanoylphorbol-13-acetate on cultured normal and neoplastic human bronchial epithelial cells.

1984 • 58 citations

The sequence of ultrastructural changes in cultured neurons after dendrite transection

1987 • 56 citations

Ion regulation, cell injury and carcinogenesis

1987 • 52 citations

Relationship between calcium loading and impaired energy metabolism during Na+, K+ pump inhibition and metabolic inhibition in cultured neonatal rat cardiac myocytes.

1989 • 47 citations

Effects of platelet‐derived growth factor and fibroblast growth factor on free intracellular calcium and mitogenesis

1989 • 46 citations

A single-photon imaging system for the simultaneous quantitation of luminescent emissions from multiple samples

1988 • 42 citations

Expression of luciferases from Vibrio harveyi and Vibrio fischeri in filamentous cyanobacteria

1986 • 40 citations

Real-time visualization of oxyradical burst from single neutrophil by using ultrasensitive video intensifier microscopy

1987 • 38 citations

Photon counting imaging: applications in biomedical research.

1989 • 34 citations

Illumination and detection systems for quantitative fluorescence microscopy

1987 • 32 citations

Primary cultures of normal rat kidney proximal tubule epithelial cells for studies of renal cell injury

1991 • 32 citations

Studies of cellular injury in isolated flounder tubules. 3. Light microscopic and functional changes due to cyanide.

1968 • 21 citations

Effects of serum, transforming growth factor type beta, or 12-O-tetradecanoyl-phorbol-13-acetate on ionized cytosolic calcium concentration in normal and transformed human bronchial epithelial cells.

1989 • 20 citations

A dual microtiter plate (192 sample) luminometer employing computer-aided single-photon imaging applicable to cellular luminescence and luminescence immunoassay

1989 • 20 citations

Effects of palytoxin or ouabain on growth and squamous differentiation of human bronchial epithelial cells in vitro

1988 • 19 citations

Human tissues in biomedical research

1979 • 18 citations

Cellular Ion Regulation and Disease: A Hypothesis

1985 • 17 citations

Chapter 14 Quantitative Fluorescence Microscopy Using Photomultiplier Tubes and Imaging Detectors

1988 • 15 citations

Role of Ion Regulation in Cell Injury, Cell Death, and Carcinogenesis

1989 • 12 citations

Effects of Cyclosporine on Human Endothelial Cell Cultures

1986 • 8 citations

The application of a photon-counting camera in very sensitive, bioluminescence-enhanced detection systems for protein blotting. Ultrasensitive detection systems for protein blotting and DNA hybridization, II.

1988 • 4 citations

Human Tissues and Cells in Biomedical Research

1983 • 4 citations