A Novel H+ Conductance in Eosinophils

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

2014 • 5,592 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

Oxygen Metabolism and the Toxic Properties of Phagocytes

1980 • 886 citations

[41] Modification of histidyl residues in proteins by diethylpyrocarbonate

1977 • 813 citations

The biochemical basis of the NADPH oxidase of phagocytes

1993 • 631 citations

The respiratory burst oxidase.

1994 • 608 citations

Enzymic mechanisms of superoxide production

1991 • 475 citations

The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH

1981 • 429 citations

The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel

1987 • 335 citations

Hydrogen ion currents and intracellular pH in depolarized voltage-clamped snail neurones

1982 • 316 citations

Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue

1995 • 272 citations

Mechanisms of phagocytosis

1996 • 265 citations

The Human Neutrophil Respiratory Burst Oxidase

1990 • 225 citations

Voltage-Dependent Proton Transport by the Voltage Sensor of the Shaker K+ Channel

1997 • 224 citations

NADPH oxidase of neutrophils

1996 • 208 citations

Electron currents generated by the human phagocyte NADPH oxidase

1998 • 206 citations

Gp91 ^phox is the heme binding subunit of the superoxide-generating NADPH oxidase

1998 • 198 citations

The voltage-activated hydrogen ion conductance in rat alveolar epithelial cells is determined by the pH gradient.

1995 • 182 citations

Rapidly activating hydrogen ion currents in perfused neurones of the snail, Lymnaea stagnalis.

1984 • 173 citations

Potential, pH, and arachidonate gate hydrogen ion currents in human neutrophils

1993 • 170 citations

Intracellular pH modulates the generation of superoxide radicals by human neutrophils.

1985 • 156 citations

Hydrogen ion currents in rat alveolar epithelial cells

1991 • 137 citations

Proton conductance of the plasma membrane: properties, regulation, and functional role

1993 • 136 citations

Proton secretion by stimulated neutrophils. Significance of hexose monophosphate shunt activity as source of electrons and protons for the respiratory burst.

1984 • 135 citations

Voltage-activated hydrogen ion currents

1994 • 132 citations

Superoxide generation by the electrogenic NADPH oxidase of human neutrophils is limited by the movement of a compensating charge.

1988 • 132 citations

A pH-sensitive and voltage-dependent proton conductance in the plasma membrane of macrophages.

1993 • 132 citations

Determinants of the phagosomal pH in macrophages. In situ assessment of vacuolar H(+)-ATPase activity, counterion conductance, and H+ “leak”.

1991 • 131 citations

Intracellular pH regulation during spreading of human neutrophils.

1996 • 128 citations

Cytoplasmic pH regulation in phorbol ester-activated human neutrophils

1986 • 126 citations

Proton currents in human granulocytes: regulation by membrane potential and intracellular pH.

1993 • 124 citations

A voltage‐gated hydrogen ion current in the oocyte membrane of the axolotl, Ambystoma.

1984 • 116 citations

The Arachidonate-activable, NADPH Oxidase-associated H+ Channel

1995 • 104 citations

The NADPH Oxidase of Phagocytic Leukocytes^a

1997 • 93 citations

Protein kinase C activates an H+ (equivalent) conductance in the plasma membrane of human neutrophils.

1991 • 92 citations

Characterization of the amiloride-sensitive Na+-H+ antiport of human neutrophils

1986 • 89 citations

Extracellular proton release by stimulated neutrophils.

1981 • 86 citations

SITE-DIRECTED MUTAGENESIS AND ION-GRADIENT DRIVEN ACTIVE TRANSPORT: On the Path of the Proton

1988 • 83 citations

Voltage‐activated proton current in eosinophils from human blood.

1996 • 81 citations

The arachidonate-activatable, NADPH oxidase-associated H+ channel is contained within the multi-membrane-spanning N-terminal region of gp91-phox

1997 • 79 citations

Phorbol 12-myristate 13-acetate activates an electrogenic H+-conducting pathway in the membrane of neutrophils

1992 • 72 citations

Effect of diethylpyrocarbonate on lactose/proton symport in Escherichia coli membrane vesicles.

1979 • 66 citations

A voltage‐dependent proton current in cultured human skeletal muscle myotubes.

1993 • 62 citations

Proton currents in human eosinophils

1996 • 59 citations

The mammalian Na+/H+ antiporters NHE-1, NHE-2, and NHE-3 are electroneutral and voltage independent, but can couple to an H+ conductance.

1995 • 59 citations

Mutational analysis of transmembrane histidines in the amiloride-sensitive Na+/H+ exchanger

1995 • 57 citations

Role of Histidines Identified by Mutagenesis in the NADPH Oxidase-associated H+ Channel

1998 • 56 citations

Abnormal activation of H+ conductance in NADPH oxidase-defective neutrophils.

1993 • 49 citations

Assessment of the contribution of the cytochrome b moiety of the NADPH oxidase to the transmembrane H+ conductance of leukocytes.

1994 • 47 citations

Studies on the electron-transfer mechanism of the human neutrophil NADPH oxidase

1989 • 42 citations

Killing of pathogens associated with chronic granulomatous disease by the non-oxidative microbicidal mechanisms of human neutrophils

1991 • 39 citations

Proton channels, plasma membrane potential, and respiratory burst in human neutrophils

1993 • 35 citations

Activation of H+ conductance in neutrophils requires assembly of components of the respiratory burst oxidase but not its redox function.

1994 • 35 citations

Electrogenic H+ pathway contributes to stimulus-induced changes of internal pH and membrane potential in intact neutrophils: role of cytoplasmic phospholipase A2

1997 • 34 citations

Four varieties of voltage-gated proton channels

1998 • 32 citations

Impairment of Na⁺/H⁺ exchange underlies inhibitory effects of Na⁺‐free media on leukocyte function

1986 • 29 citations

Leukocyte Disorders: Quantitative and Qualitative Disorders of the Neutrophil, Part 1

1996 • 27 citations

Development of a H(+)-selective conductance during granulocytic differentiation of HL-60 cells

1994 • 26 citations

Inwardly rectifying whole cell potassium current in human blood eosinophils

1998 • 26 citations

Depolarization blunts the oxidative burst of human neutrophils. Parallel effects of monoclonal antibodies, depolarizing buffers, and glycolytic inhibitors.

1988 • 25 citations

The antimicrobial role of the neutrophil leukocyte

1981 • 16 citations

The NADPH Oxidase: Lessons from Chronic Granulomatous Disease Neutrophils

1997 • 13 citations

Lymphocytes possess an electrogenic H+-transporting pathway in their plasma membrane

1994 • 12 citations

Ligands of purinergic receptors stimulate electrogenic H⁺‐transport of neutrophils

1995 • 9 citations

Genetic variation in chronic granulomatous disease.

1990 • 5 citations

Leukocyte Disorders: Quantitative and Qualitative Disorders of the Neutrophil, Part 1

1996 • 2 citations