The NADPH Oxidase: Lessons from Chronic Granulomatous Disease Neutrophils

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

1983 • 1,808 citations

Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal location

1986 • 839 citations

Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000.

1987 • 459 citations

Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease

1996 • 424 citations

Two Cytosolic Neutrophil Oxidase Components Absent in Autosomal Chronic Granulomatous Disease

1988 • 401 citations

Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 ^c-src

1990 • 393 citations

Cytochrome b ₅₅₈ : the Flavin-Binding Component of the Phagocyte NADPH Oxidase

1992 • 384 citations

Activation of NADPH-dependent superoxide production in a cell-free system by sodium dodecyl sulfate.

1985 • 356 citations

Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes

1992 • 351 citations

Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease

1989 • 341 citations

Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.

1990 • 337 citations

Novel cytochrome b system in phagocytic vacuoles of human granulocytes

1978 • 335 citations

Two Forms of Autosomal Chronic Granulomatous Disease Lack Distinct Neutrophil Cytosol Factors

1988 • 327 citations

Absence of both cytochrome b−245 subunits from neutrophils in X-linked chronic granulomatous disease

1987 • 324 citations

Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.

1989 • 310 citations

Molecular basis of chronic granulomatous disease [see comments]

1991 • 290 citations

A fast and easy method to determine the production of reactive oxygen intermediates by human and murine phagocytes using dihydrorhodamine 123

1990 • 289 citations

Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.

1994 • 286 citations

Activation of a NADPH Oxidase From Horse Polymorphonuclear Leukocytes in a Cell- Free System

1984 • 221 citations

Molecular basis of chronic granulomatous disease [see comments]

1991 • 210 citations

Oxygen consumption of phagocytizing cells in human leukocyte and granulocyte preparations: a comparative study.

1974 • 204 citations

Characterization of two monoclonal antibodies against cytochrome b558 of human neutrophils

1989 • 170 citations

A semi-automated micro-assay for H2O2 release by human blood monocytes and mouse peritoneal macrophages

1985 • 152 citations

Evidence for a functional cytoplasmic domain of phagocyte oxidase cytochrome b558.

1990 • 134 citations

Genotype-dependent variability in flow cytometric evaluation of reduced nicotinamide adenine dinucleotide phosphate oxidase function in patients with chronic granulomatous disease

1996 • 125 citations

A structural model for the nucleotide binding domains of the flavocytochrome b_–245 β‐chain

1993 • 124 citations

Phorbol myristate acetate-induced NADPH oxidase activity in human neutrophils: only half the story has been told

1996 • 123 citations

Cytochrome b558, a component of the phagocyte NADPH oxidase, is a flavoprotein

1992 • 118 citations

Cytochrome b−245 of the Neutrophil Superoxide-generating System Contains Two Nonidentical Hemes

1995 • 114 citations

A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox.

1994 • 109 citations

156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox.

1994 • 107 citations

The Cytosolic Activating Factors p47phox and p67phox Have Distinct Roles in the Regulation of Electron Flow in NADPH Oxidase

1995 • 104 citations

Generation of Superoxide by purified and relipidated cytochrome b₅₅₉ in the absence of cytosolic activators

1993 • 99 citations

Human neutrophil cytochrome b contains multiple hemes. Evidence for heme associated with both subunits.

1992 • 95 citations

Disturbed interaction of p21-rac with mutated p67-phox causes chronic granulomatous disease.

1996 • 87 citations

The superoxide-generating system of human neutrophils possesses a novel diaphorase activity. Evidence for distinct regulation of electron flow within NADPH oxidase by p67-phox and p47-phox.

1994 • 86 citations

Limitations on the use of dihydrorhodamine 123 for flow cytometric analysis of the neutrophil respiratory burst

1996 • 85 citations

Affinity Labeling of the Cytosolic and Membrane Components of the Respiratory Burst Oxidase by the 2′,3′-Dialdehyde Derivative of NADPH

1989 • 72 citations

p22-phox-deficient chronic granulomatous disease: reconstitution by retrovirus-mediated expression and identification of a biosynthetic intermediate of gp91-phox

1994 • 67 citations

A Variant X-linked Chronic Granulomatous Disease Patient (X91+) with Partially Functional Cytochrome b

1995 • 66 citations

Superoxide production by cytochrome b₅₅₉

1994 • 66 citations

p67-phox enhances the binding of p47-phox to the human neutrophil respiratory burst oxidase complex.

1994 • 58 citations

Heterogeneity in Chronic Granulomatous Disease Detected With an Improved Nitroblue Tetrazolium Slide Test

1986 • 49 citations

Characterization of a phagocyte cytochrome b558 91-kilodalton subunit functional domain: identification of peptide sequence and amino acids essential for activity

1992 • 47 citations

Immunocytochemical discovery of the 22- to 23-Kd subunit of cytochrome b558 at the surface of human peripheral phagocytes

1988 • 44 citations

Current concepts about neutrophil granule physiology

1996 • 40 citations

Detection of gp91-phox precursor protein in B-cell lines from patients with X-linked chronic granulomatous disease as an indicator for mutations impairing cytochrome b558 biosynthesis

1996 • 31 citations

A new mutation in exon 12 of the gp91-phox gene leading to cytochrome b- positive X-linked chronic granulomatous disease

1995 • 24 citations