Interaction between a Ca²⁺-Binding Protein Calreticulin and Perforin, a Component of the Cytotoxic T-Cell Granules

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Control of Protein Exit from the Endoplasmic Reticulum

1989 • 794 citations

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.

1991 • 693 citations

Molecular cloning of the high affinity calcium-binding protein (calreticulin) of skeletal muscle sarcoplasmic reticulum

1989 • 417 citations

Calreticulin

1992 • 402 citations

Expression of calreticulin in Escherichia coli and identification of its Ca2+ binding domains.

1991 • 350 citations

Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors.

1984 • 337 citations

Enhanced Catalysis of Ribonuclease B Folding by the Interaction of Calnexin or Calreticulin with ERp57

1998 • 329 citations

Monitoring dynamic changes in free Ca2+ concentration in the endoplasmic reticulum of intact cells.

1995 • 308 citations

Definition of the Lectin-like Properties of the Molecular Chaperone, Calreticulin, and Demonstration of Its Copurification with Endomannosidase from Rat Liver Golgi

1996 • 280 citations

A set of endoplasmic reticulum proteins possessing properties of molecular chaperones includes Ca(2+)-binding proteins and members of the thioredoxin superfamily.

1994 • 279 citations

Perforin-Mediated Target Cell Lysis by Cytolytic T Lymphocytes

1990 • 268 citations

Overexpression of Calreticulin Increases Intracellular Ca2+ Storage and Decreases Store-operated Ca2+ Influx

1996 • 266 citations

Calreticulin Functions as a Molecular Chaperone in the Biosynthesis of Myeloperoxidase

1995 • 260 citations

Calreticulin, and not calsequestrin, is the major calcium binding protein of smooth muscle sarcoplasmic reticulum and liver endoplasmic reticulum.

1991 • 236 citations

Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors.

1984 • 219 citations

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain

1997 • 195 citations

Overexpression of calreticulin increases the Ca2+ capacity of rapidly exchanging Ca2+ stores and reveals aspects of their lumenal microenvironment and function.

1995 • 191 citations

Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor.

1993 • 177 citations

Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography.

1986 • 166 citations

Cell attachment to extracellular matrix substrates is inhibited upon downregulation of expression of calreticulin, an intracellular integrin α-subunit-binding protein

1994 • 148 citations

Calreticulin modulates cell adhesiveness via regulation of vinculin expression.

1996 • 142 citations

Inducible Interaction of Integrin α2β1 with Calreticulin

1995 • 137 citations

The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes.

1993 • 137 citations

Endoplasmic Reticulum Form of Calreticulin Modulates Glucocorticoid-sensitive Gene Expression

1996 • 122 citations

Interaction of Calreticulin with Protein Disulfide Isomerase

1995 • 115 citations

Mechanisms of Lysis by Cytotoxic T Cells

1995 • 79 citations

A serine protease (CCP1) is sequestered in the cytoplasmic granules of cytotoxic T lymphocytes.

1987 • 41 citations

Fractionation of perforin and granzymes by immobilized metal affinity chromatography (IMAC)

1996 • 25 citations

Calreticulin

1996 • 16 citations