Fractionation of perforin and granzymes by immobilized metal affinity chromatography (IMAC)

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Tissue sulfhydryl groups

1959 • 25,130 citations

Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue

1986 • 3,282 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.

1983 • 938 citations

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.

1991 • 693 citations

Protein Purification

2011 • 476 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules.

1985 • 398 citations

Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors.

1984 • 337 citations

Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity

1986 • 316 citations

Natural killer (NK) cell activity in the rat. I. Isolation and characterization of the effector cells.

1981 • 284 citations

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1991 • 255 citations

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.

1994 • 224 citations

Thiobenzyl benzyloxycarbonyl-l-lysinate, substrate for a sensitive colorimetric assay for trypsin-like enzymes

1979 • 176 citations

Interaction of chondroitin sulfate with perforin and granzymes of cytolytic T-cells is dependent on pH

1990 • 101 citations

Subcellular localization of perforin and serine esterase in lymphokine-activated killer cells and cytotoxic T cells by immunogold labeling.

1991 • 50 citations

Molecular cloning of rat cytolysin.

1989 • 39 citations

Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods

1993 • 29 citations

Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules

1986 • 29 citations

Fractionation of granule proteins of granulocytes by copper chelate chromatography

1979 • 28 citations

Lysis by RNK-16 cytotoxic lymphocyte granules

1988 • 15 citations

Cytotoxic cells: recognition, effector function, generation and methods

1994 • 11 citations

Measurement of Cytolysin Hemolytic Activity

1993 • 2 citations