Parkinson's Disease-associated α-Synuclein Is More Fibrillogenic than β- and γ-Synuclein and Cannot Cross-seed Its Homologs

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Empirical Predictions of Protein Conformation

1978 • 3,167 citations

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

1998 • 2,898 citations

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

1998 • 1,546 citations

Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

2000 • 1,497 citations

Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

1998 • 1,460 citations

Neuropathology of Parkinsonʼs Disease

1996 • 1,457 citations

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

1993 • 1,426 citations

Protein secondary structures in water from second-derivative amide I infrared spectra

1990 • 1,271 citations

Identification of two distinct synucleins from human brain

1994 • 1,031 citations

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons.

2000 • 830 citations

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease

1998 • 756 citations

Synucleins Are Developmentally Expressed, and α-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal Neurons

2000 • 724 citations

Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation

2000 • 714 citations

Both Familial Parkinson's Disease Mutations Accelerate α-Synuclein Aggregation

1999 • 695 citations

α-Synuclein Fibrillogenesis Is Nucleation-dependent

1999 • 686 citations

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein

1998 • 647 citations

Subcellular Localization of Wild-Type and Parkinson's Disease-Associated Mutant α-Synuclein in Human and Transgenic Mouse Brain

2000 • 629 citations

Mutant and Wild Type Human α-Synucleins Assemble into Elongated Filaments with Distinct Morphologies in Vitro

1999 • 510 citations

Infrared Spectroscopic Studies of Lyophilization‐ and Temperature‐Induced Protein Aggregation

1995 • 454 citations

Axon pathology in Parkinson’s disease and Lewy body dementia hippocampus contains α-, β-, and γ-synuclein

1999 • 417 citations

Pathology and Biology of the Lewy Body

1993 • 394 citations

Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinsonʼs Disease and Cortical Lewy Body Disease Contain α-synuclein Immunoreactivity

1998 • 393 citations

Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy

1998 • 350 citations

A selective imaging of tinnitus

1999 • 342 citations

Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing.

1997 • 328 citations

Human recombinant NACP/α-synuclein is aggregated and fibrillated in vitro: Relevance for Lewy body disease

1998 • 264 citations

Effects of the mutations Ala³⁰ to Pro and Ala⁵³ to Thr on the physical and morphological properties of α‐synuclein protein implicated in Parkinson's disease

1998 • 263 citations

NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

1998 • 240 citations

[5] The measurement of cooperative protein self-assembly by turbidity and other techniques

1986 • 82 citations

Argyrophilic glial inclusions in the midbrain of patients with Parkinson's disease and diffuse Lewy body disease are immunopositive for NACP/α-synuclein

1999 • 79 citations

Handbuch der Neurologie

1911 • 50 citations

Genomic Organization and Expression of the Human β-Synuclein Gene (SNCB)

1998 • 38 citations

No pathogenic mutations in the β-synuclein gene in Parkinson's disease

1999 • 26 citations

No pathogenic mutations in the persyn gene in Parkinson's disease

1999 • 18 citations

Immunological aspects of acetycholine receptors

1983 • 8 citations