Microtubule-associated protein tau, heparan sulphate and α-synuclein in several neurodegenerative diseases with dementia

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

1998 • 2,898 citations

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

1998 • 1,546 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

1993 • 1,426 citations

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1998 • 1,344 citations

Identification of two distinct synucleins from human brain

1994 • 1,031 citations

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

1989 • 783 citations

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

1994 • 726 citations

Tau protein pathology in neurodegenerative diseases

1998 • 674 citations

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205

1995 • 551 citations

The occult aftermath of boxing.

1990 • 522 citations

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.

1992 • 509 citations

Developmental changes in heparan sulfate expression: in situ detection with mAbs.

1992 • 464 citations

Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies

1998 • 459 citations

Monoclonal antibody PHF‐1 recognizes tau protein phosphorylated at serine residues 396 and 404

1994 • 451 citations

Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders.

1998 • 403 citations

Silver staining of Alzheimer's neurofibrillary changes by means of physical development.

1971 • 402 citations

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

1994 • 349 citations

Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau

1995 • 345 citations

Familial multiple system tauopathy with presenile dementia: A disease with abundant neuronal and glial tau filaments

1997 • 334 citations

Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes

1992 • 334 citations

A COMPARATIVE STUDY OF MODIFIED BIELSCHOWSKY, BODIAN AND THIOFLAVIN S STAINS ON ALZHEIMER'S NEUROFIBRILLARY TANGLES

1986 • 326 citations

NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease

1997 • 322 citations

Straight and paired helical filaments in Alzheimer disease have a common structural unit.

1991 • 310 citations

Sequential phosphorylation of Tau by glycogen synthase kinase‐3β and protein kinase A at Thr212 and Ser214 generates the Alzheimer‐specific epitope of antibody AT100 and requires a paired‐helical‐filament‐like conformation

1998 • 308 citations

Neurodegenerative disorders with extensive tau pathology: A comparative study and review

1996 • 280 citations

Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP.

1996 • 275 citations

CORTICAL AND SUBCORTICAL ARGYROPHILIC GRAINS CHARACTERIZE A DISEASE ASSOCIATED WITH ADULT ONSET DEMENTIA

1989 • 273 citations

Widespread cytoskeletal pathology characterizes corticobasal degeneration.

1995 • 271 citations

Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein containing lesions of Alzheimer's disease and Down's syndrome

1990 • 245 citations

Alz-50, Ubiquitin and Tau Immunoreactivity of Neurofibrillary Tangles, Pick Bodies and Lewy Bodies

1988 • 238 citations

Abnormal Tau proteins in progressive supranuclear palsy

1991 • 235 citations

Down patients: Extracellular preamyloid deposits precede neuritic degeneration and senile plaques

1989 • 233 citations

Vulnerable neuronal subsets in Alzheimer's and Pick's disease are distinguished by their τ isoform distribution and phosphorylation

1998 • 231 citations

Specific Pathological Tau Protein Variants Characterize Pickʼs Disease

1996 • 218 citations

Glial Inclusions in CNS Degenerative Diseases

1996 • 209 citations

Characterization of the Precursor Protein of the Non-Aβ Component of Senile Plaques (NACP) in the Human Central Nervous System

1996 • 202 citations

Neurofibrillary tangles in Niemann—Pick disease type C

1995 • 202 citations

Ultrastructure and biochemical composition of paired helical filaments in corticobasal degeneration.

1994 • 183 citations

Neurofibrillary tangles in Niemann-Pick disease type C

1995 • 179 citations

Pick's disease: hyperphosphorylated tau protein segregates to the somatoaxonal compartment

1996 • 176 citations

Gerstmann‐Sträussler‐Scheinker disease II. Neurofibrillary tangles and plaques with PrP‐amyloid coexist in an affected family

1989 • 173 citations

Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease

1991 • 167 citations

Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques

1997 • 165 citations

Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles

1996 • 157 citations

Unique Alzheimer's Disease Paired Helical Filament Specific Epitopes Involve Double Phosphorylation at Specific Sites

1997 • 151 citations

Specific tau variants in the brains of patients with myotonic dystrophy

1996 • 144 citations

Immunocytochemical and ultrastructural studies of Pick's disease

1990 • 142 citations

Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences

1987 • 125 citations

Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam. Immunochemical characterization of tau proteins.

1995 • 124 citations

Familial presenile dementia with psychosis associated with cortical neurofibrillary tangles and degeneration of the amygdala

1992 • 117 citations

Corticonigral degeneration with neuronal achromasia and basal neurofibrillary tangles

1990 • 117 citations

Neurofibrillary tangle predominant form of senile dementia of Alzheimer type: a rare subtype in very old subjects

1994 • 108 citations

Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons

1997 • 107 citations

Assignment of Human α-Synuclein (SNCA) and β-Synuclein (SNCB) Genes to Chromosomes 4q21 and 5q35

1995 • 103 citations

Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics

1994 • 102 citations

Epitope expression and hyperphosphorylation of tau protein in corticobasal degeneration: differentiation from progressive supranuclear palsy

1995 • 94 citations

Phosphorylation of Tau proteins: a major event during the process of neurofibrillary degeneration. A comparative study between Alzheimer's disease and Down's syndrome

1990 • 83 citations

Argyrophilic grain disease: distribution of grains in patients with and without dementia

1997 • 82 citations

Abundant neurofibrillary tangles without senile plaques in a subset of patients with senile dementia

1992 • 78 citations

Presenile appearance of abundant Alzheimer's neurofibrillary tangles without senile plaques in the brain in myotonic dystrophy

1991 • 76 citations

Neurofibrillary tangle distribution in the cerebral cortex of parkinsonism-dementia cases from Guam: differences with Alzheimer's disease

1991 • 74 citations

The Neurofibrillary Pathology of Alzheimer's Disease

1997 • 73 citations

Cationic dyes reveal proteoglycans structurally integrated within the characteristic lesions of Alzheimer's disease

1989 • 67 citations

Cognitive, neuroimaging, and pathological studies in a patient with Pick's disease

1998 • 54 citations

A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred

1993 • 53 citations

Association of measles virus with neurofibrillary tangles in subacute sclerosing panencephalitis: a combined in situ hybridization and immunocytochemical investigation

1994 • 52 citations

Ultrastructural instability of paired helical filaments from corticobasal degeneration as examined by scanning transmission electron microscopy.

1996 • 49 citations

Numerous glial fibrillary tangles in oligodendroglia in cases of subacute sclerosing panencephalitis with neurofibrillary tangles

1995 • 49 citations

Parenchymal preamyloid and amyloid deposits in the brains of patients with hereditary cerebral hemorrhage with amyloidosis—Dutch type

1990 • 46 citations

The distribution of Alzheimer's neurofibrillary tangles and gliosis in chronic subacute sclerosing panencephalitis

1990 • 29 citations

Relationship of amyloid ?/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia

1995 • 27 citations

Motor neuron disease with neurofibrillary tangles in a non-Guamanian patient

1995 • 17 citations