The Role of Cytokines in Functional Regulation and Differentiation of Dendritic Cells

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Purification and Characterization of Mouse Hematopoietic Stem Cells

1988 • 2,856 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Interleukin-10

1993 • 1,820 citations

GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

1992 • 1,608 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE

1974 • 1,041 citations

Epidermal Langerhans cells are derived from cells originating in bone marrow

1979 • 879 citations

Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology.

1994 • 866 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

Mast cells as a source of multifunctional cytokines

1990 • 708 citations

Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset

1995 • 687 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.

1990 • 670 citations

Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature.

1994 • 626 citations

Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide

1993 • 615 citations

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

1994 • 607 citations

Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies.

1987 • 592 citations

Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain.

1981 • 589 citations

Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance.

1993 • 526 citations

Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells.

1991 • 512 citations

Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo.

1993 • 487 citations

Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody.

1986 • 478 citations

Phagocytosis of antigens by Langerhans cells in vitro.

1993 • 474 citations

Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1.

1995 • 472 citations

Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow.

1992 • 452 citations

Identification of proliferating dendritic cell precursors in mouse blood.

1992 • 445 citations

Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow.

1993 • 428 citations

The distinct surface of human blood dendritic cells, as observed after an improved isolation method.

1990 • 402 citations

Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium.

1993 • 395 citations

Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets

1994 • 391 citations

Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.

1994 • 379 citations

Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura.

1986 • 370 citations

Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets.

1993 • 347 citations

Interleukin‐4 and interleukin‐10 synergize to inhibit cell‐mediated immunity in vivo

1993 • 341 citations

The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus

1989 • 318 citations

Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines.

1995 • 318 citations

The endocytic activity of dendritic cells.

1995 • 308 citations

Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs

1995 • 308 citations

Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo

1994 • 300 citations

Identification of dendritic cell colony-forming units among normal human CD34+ bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha.

1995 • 296 citations

Successful T cell priming in B cell-deficient mice.

1995 • 284 citations

Interleukin‐10 differentially regulates B7‐1 (CD80) and B7‐2 (CD86) expression on human peripheral blood dendritic cells

1995 • 282 citations

Propagation of dendritic cell progenitors from normal mouse liver using granulocyte/macrophage colony-stimulating factor and their maturational development in the presence of type-1 collagen.

1994 • 247 citations

Isolation and characterization of human peripheral blood dendritic cells.

1993 • 240 citations

Lymphokine enhances the expression and synthesis of Ia antigens on cultured mouse peritoneal macrophages.

1980 • 238 citations

Induction of hapten-specific tolerance by interleukin 10 in vivo.

1994 • 232 citations

Tumor necrosis factor alpha maintains the viability of murine epidermal Langerhans cells in culture, but in contrast to granulocyte/macrophage colony-stimulating factor, without inducing their functional maturation.

1990 • 227 citations

Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer.

1992 • 224 citations

Spontaneous apoptosis of dendritic cells is efficiently inhibited by TRAP (CD40‐ligand) and TNF‐α, but strongly enhanced by interleukin‐10

1995 • 215 citations

Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain.

1990 • 214 citations

Tumor antigen presentation by murine epidermal cells.

1991 • 211 citations

Interleukin 10 inhibits T cell alloreaction induced by human dendritic cells

1994 • 205 citations

Mouse epidermal Ia molecules have a bone marrow origin

1979 • 203 citations

Studies of human cord blood dendritic cells: evidence for functional immaturity

1994 • 196 citations

IL-10 inhibits tumor antigen presentation by epidermal antigen-presenting cells.

1995 • 194 citations

Development of the airway intraepithelial dendritic cell network in the rat from class II major histocompatibility (Ia)-negative precursors: differential regulation of Ia expression at different levels of the respiratory tract.

1994 • 190 citations

Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells.

1991 • 187 citations

Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor.

1995 • 185 citations

Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells.

1995 • 185 citations

Dendritic cells from mouse bone marrow: In vitro differentiation using low doses of recombinant granulocyte-macrophage colony-stimulating factor

1992 • 179 citations

Isolation and characterization of dendritic cells from mouse heart and kidney.

1994 • 179 citations

Epidermal Langerhans Cells

2024 • 172 citations

Tumor necrosis factor-alpha strongly potentiates interleukin-3 and granulocyte-macrophage colony-stimulating factor-induced proliferation of human CD34+ hematopoietic progenitor cells

1990 • 171 citations

Expression and function of B7 on human epidermal Langerhans cells.

1993 • 166 citations

The antigen-presenting activities of Ia+ dendritic cells shift dynamically from lung to lymph node after an airway challenge with soluble antigen.

1995 • 166 citations

Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.

1993 • 164 citations

The injured cell: the role of the dendritic cell system as a sentinel receptor pathway

1995 • 154 citations

Cytokine gene expression in murine epidermal cell suspensions: interleukin 1 beta and macrophage inflammatory protein 1 alpha are selectively expressed in Langerhans cells but are differentially regulated in culture.

1992 • 152 citations

Interleukin‐10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells

1994 • 151 citations

Interleukin‐4 and interleukin‐10 synergize to inhibit cell‐mediated immunity in vivo

1993 • 142 citations

The immunologic properties of epidermal Langerhans cells as a part of the dendritic cell system

1992 • 140 citations

Cytokine pattern of Langerhans cells isolated from murine epidermal cell cultures.

1992 • 131 citations

Identification of immunostimulatory dendritic cells in the synovial effusions of patients with rheumatoid arthritis.

1985 • 128 citations

Modulation of epidermal Langerhans' cell frequency by tumour necrosis factor-alpha.

1994 • 126 citations

Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo.

1995 • 121 citations

Dendritic cells, the major antigen-presenting cells of the human colonic lamina propria.

1993 • 115 citations

Different cytokines regulate antigen uptake and presentation of a precursor dendritic cell line

1996 • 114 citations

Comparative analysis of B7‐1 and B7‐2 expression in Langerhans cells: differential regulation by T helper type 1 and T helper type 2 cytokines

1995 • 111 citations

The normal Langerhans cell and the LCH cell.

1994 • 111 citations

Establishment of a cell line with features of early dendritic cell precursors from fetal mouse skin

1995 • 109 citations

Immortalized dendritic cell line fully competent in antigen presentation initiates primary T cell responses in vivo.

1993 • 108 citations

Functional expression of CD40 antigen on human epidermal Langerhans cells.

1995 • 108 citations

Dendritic Cells in Fundamental and Clinical Immunology

1995 • 108 citations

Differentiation of Rat Bone Marrow Cells Into Macrophages Under the Influence of Mouse L929 Cell Supernatant

1987 • 107 citations

Expression and factor-dependent modulation of the interleukin-3 receptor subunits on human hematopoietic cells

1993 • 107 citations

Langerhans Cells Are the Major Source of mRNA for IL-1β and MIP-1α Among Unstimulated Mouse Epidermal Cells

1992 • 105 citations

Low‐dose UVB radiation perturbs the functional expression of B7.1 and B7.2 co‐stimulatory molecules on human Langerhans cells

1995 • 104 citations

Characterization of the gamma-interferon-mediated induction of antigen-presenting ability in P388D1 cells.

1983 • 101 citations

Uptake of microparticle‐adsorbed protein antigen by bone marrow‐derived dendritic cells results in up‐regulation of interleukin‐1α and interleukin‐12 p40/p35 and triggers prolonged, efficient antigen presentation

1995 • 98 citations

Dendritic cells: a major story unfolds

1995 • 97 citations

Mechanisms of tumor necrosis factor-granulocyte-macrophage colony- stimulating factor-induced dendritic cell development

1993 • 92 citations

Membrane and soluble Fc gamma RII/III modulate the antigen-presenting capacity of murine dendritic epidermal Langerhans cells for IgG-complexed antigens.

1995 • 82 citations

Expression of E‐cadherin by murine dendritic cells: E‐cadherin as a dendritic cell differentiation antigen characteristic of epidermal Langerhans cells and related cells

1994 • 82 citations

Understanding the dendritic cell lineage through a study of cytokine receptors.

1994 • 81 citations

Differentiation of dendritic cells in cultures of rat bone marrow cells.

1986 • 79 citations

Cytokine-dependent regulation of growth and maturation in murine epidermal dendritic cell lines

1995 • 75 citations

Isolation and Function of Human Dendritic Cells

1994 • 71 citations

B7/BB-1 is a leucocyte differentiation antigen on human dendritic cells induced by activation.

1993 • 70 citations

Up-Regulation of α4 Integrin on Activated Langerhans Cells: Analysis of Adhesion Molecules on Langerhans Cells Relating to Their Migration from Skin to Draining Lymph Nodes

1993 • 68 citations

Differentiation of Human Monocytes into CD14 Negative Accessory Cells: Do Dendritic Cells Derive from the Monocytic Lineage?

1991 • 67 citations

Selective regulation of ICAM‐1 and major histocompatibility complex class I and II molecule expression on epidermal Langerhans cells by some of the cytokines released by keratinocytes and T cells

1994 • 67 citations

Expression of the mucosal T cell integrin αM290β7 by a major subpopulation of dendritic cells in mice

1993 • 63 citations

Development of a Langerhans cell phenotype from peripheral blood monocytes

1992 • 63 citations

Fetal skin-derived MHC class I+, MHC class II- dendritic cells stimulate MHC class I-restricted responses of unprimed CD8+ T cells.

1994 • 55 citations

Retroviral immortalization of phagocytic and dendritic cell clones as a tool to investigate functional heterogeneity

1994 • 54 citations

Autoimmune diabetes results from genetic defects manifest by antigen presenting cells

1993 • 48 citations

Interleukin‐1β converting enzyme in murine Langerhans cells and epidermal‐derived dendritic cell lines

1995 • 47 citations

Modulation of cytokine expression in mouse dendritic cell clones

1994 • 47 citations

Costimulator deficient antigen presentation by an endothelial cell line induces a nonproliferative T cell activation response without anergy.

1993 • 45 citations

Bacteria and bacterial cell wall constituents induce the production of regulatory cytokines in dendritic cell clones.

1996 • 43 citations

Regulation of Expression of B7 by Murine Langerhans Cells: A Direct Relationship Between B7 mRNA Levels and the Level of Surface Expression of B7 by Langerhans Cells

1993 • 42 citations

Distribution of HLA class II molecules in epidermal Langerhans cells in situ

1995 • 42 citations

Human dendritic cells stimulate allogeneic T cells in the absence of IL-1.

1989 • 38 citations

Uptake of antigen by afferent lymph dendritic cells mediated by antibody

1990 • 35 citations

T cell-dependent secretion of IL-1 beta by a dendritic cell line (XS52) derived from murine epidermis.

1995 • 34 citations

Langerhans' cell expression of the selectin ligand, sialyl Lewis x.

1994 • 32 citations

Interferon-γ inhibits tumor antigen presentation by epidermal antigen-presenting cells

1994 • 27 citations

Purified human oral mucosal Langerhans cells function as accessory cells in vitro

1993 • 26 citations

Molecular cloning of a recombinant retrovirus carrying a mutated envAKR-mycMH2 fusion gene immortalizing cells of the monocytic-macrophage lineage.

1994 • 24 citations

Ontogeny of rat thymic dendritic cells.

1994 • 22 citations

Class II antigens on dendritic cells from the synovial fluids of patients with inflammatory arthritis.

1989 • 18 citations

Regulatory role of IL4 and other cytokines in T helper cell development in an αβ TCR transgenic mouse system

1993 • 17 citations

Cultured human Langerhans' cells are superior to fresh cells at presenting native HIV-1 protein antigens to specific CD4+ T-cell lines.

1996 • 9 citations

Regulatory cellular interactions in the primary mixed lymphocyte reaction

1995 • 8 citations

Priming of T Cells with Dendritic, Macrophage and B Cell Lines in Vivo Requires More than Surface Expression of MHC II and B7 Molecules - Possible Role of CD44 and Integrins

1995 • 6 citations

Analysis of Cytokine and Cytokine Receptor Production by Human Dendritic Cells

1993 • 4 citations