Calcium influx and membrane depolarization induce phosphorylation of neurofilament (NF-M) KSP repeats in PC12 cells

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4

1996 • 2,308 citations

Calcium Signaling in Neurons: Molecular Mechanisms and Cellular Consequences

1995 • 1,421 citations

Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ.

1983 • 1,162 citations

Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras

1994 • 704 citations

A brain-specific activator of cyclin-dependent kinase 5

1994 • 575 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

Clustering of L-type Ca2+ channels at the base of major dendrites in hippocampal pyramidal neurons

1990 • 512 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Dihydropyridine receptor mutations cause hypokalemic periodic paralysis

1994 • 423 citations

Identification of the major multiphosphorylation site in mammalian neurofilaments.

1988 • 394 citations

Neurofilament phosphorylation: a new look at regulation and function

1991 • 309 citations

Subunit structure and localization of dihydropyridine-sensitive calcium channels in mammalian brain, spinal cord, and retina

1990 • 292 citations

Calcium influx induces neurite growth through a Src-Ras signaling cassette

1995 • 261 citations

A conserved kinase cascade for MAP kinase activation in yeast

1993 • 255 citations

Transmitter, ion channel and receptor properties of pheochromocytoma (PC12) cells: a model for neurotoxicological studies.

1991 • 247 citations

Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor.

1992 • 240 citations

Mitogen-Activated Protein Kinases (Erk1,2) Phosphorylate Lys-Ser-Pro (KSP) Repeats in Neurofilament Proteins NF-H and NF-M

1998 • 231 citations

cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization.

1993 • 207 citations

Serum Antibodies to L-Type Calcium Channels in Patients with Amyotrophic Lateral Sclerosis

1992 • 207 citations

Phosphorylation of Neurofilaments Is Altered in Amyotrophic Lateral Sclerosis

1988 • 198 citations

A 42-kD tyrosine kinase substrate linked to chromaffin cell secretion exhibits an associated MAP kinase activity and is highly related to a 42-kD mitogen-stimulated protein in fibroblasts.

1990 • 142 citations

Two novel kinases phosphorylate tau and the KSP site of heavy neurofilament subunits in high stoichiometric ratios

1991 • 134 citations

Aberrant Stress-induced Phosphorylation of Perikaryal Neurofilaments

1996 • 132 citations

Differential Cellular Phosphorylation of Neurofilament Heavy Side‐Arms by Glycogen Synthase Kinase‐3 and Cyclin‐Dependent Kinase‐5

1996 • 129 citations

Phosphorylation of the amino-terminal head domain of the middle molecular mass 145-kDa subunit of neurofilaments. Evidence for regulation by second messenger-dependent protein kinases.

1990 • 126 citations

Posttranslational modification of neurofilament proteins by phosphate during axoplasmic transport in retinal ganglion cell neurons

1987 • 125 citations

The structure of a human neurofilament gene (NF-L): A unique exon-intron organization in the intermediate filament gene family

1987 • 120 citations

Brain Protein Kinase PK40erk Converts TAU into a PHF-like Form as Found in Alzheimer′s Disease

1993 • 113 citations

Study of Proline-Directed Protein Kinases Involved in Phosphorylation of the Heavy Neurofilament Subunit

1997 • 93 citations

Identification of Endogenously Phosphorylated KSP Sites in the High‐Molecular‐Weight Rat Neurofilament Protein

1994 • 82 citations

Trinucleotide repeat disorders in humans: discussions of mechanisms and medical issues

1996 • 73 citations

Structure of the 68-kDa neurofilament gene and regulation of its expression.

1990 • 59 citations

Phosphorylation‐Dependent epitopes on neurofilament proteins and neurofilament densities differ in axons in the corticospinal and primary sensory dorsal column tracts in the rat spinal cord

1990 • 53 citations

Discordance between phenotype and genotype in malignant hyperthermia

1995 • 51 citations

Depolarization maintains neurites and priming of PC12 cells after nerve growth factor withdrawal

1993 • 33 citations

Protein Kinase F_A/Glycogen Synthase Kinase 3α Predominantly Phosphorylates the In Vivo Sites of Ser⁵⁰², Ser⁵⁰⁶, Ser⁶⁰³, and Ser⁶⁶⁶ in Neurofilament

1995 • 25 citations

Identification of Ser‐Pro and Thr‐Pro Phosphorylation Sites in Chicken Neurofilament‐M Tail Domain

1997 • 18 citations

Phosphorylation and dephosphorylation of distinct isoforms of the heavy neurofilament protein NF-H

1995 • 5 citations

Deleted Work

1955 • 0 citations