GTP Hydrolysis by Ran Is Required for Nuclear Envelope Assembly

Transport Between the Cell Nucleus and the Cytoplasm

1999 • 2,001 citations

A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2

1997 • 1,221 citations

NUCLEOCYTOPLASMIC TRANSPORT: The Soluble Phase

1998 • 1,184 citations

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.

1996 • 1,161 citations

Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.

1994 • 948 citations

The diversity of Rab proteins in vesicle transport

1997 • 762 citations

Nuclear Membrane Dynamics and Reassembly in Living Cells: Targeting of an Inner Nuclear Membrane Protein in Interphase and Mitosis

1997 • 753 citations

Nuclear Lamins: Their Structure, Assembly, and Interactions

1998 • 708 citations

Formation in Vitro of Sperm Pronuclei and Mitotic Chromosomes Induced by Amphibian Ooplasmic Components

1983 • 630 citations

The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

1997 • 628 citations

Nuclear reconstitution in vitro: Stages of assembly around protein-free DNA

1987 • 550 citations

Immunocytochemical localization of the major polypeptides of the nuclear pore complex-lamina fraction. Interphase and mitotic distribution.

1978 • 527 citations

RanGAP1 induces GTPase activity of nuclear Ras-related Ran.

1994 • 526 citations

Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation

1993 • 525 citations

A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles

1994 • 501 citations

A giant nucleopore protein that binds Ran/TC4

1995 • 492 citations

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

1999 • 492 citations

The nuclear lamins

1986 • 488 citations

Stimulation of Microtubule Aster Formation and Spindle Assembly by the Small GTPase Ran

1999 • 393 citations

Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes

1995 • 382 citations

The Emery-Dreifuss muscular dystrophy protein, emerin, is a nuclear membrane protein

1996 • 373 citations

A lamin B receptor in the nuclear envelope.

1988 • 370 citations

The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA.

1989 • 367 citations

A lamin-independent pathway for nuclear envelope assembly.

1990 • 350 citations

The Ran GTPase regulates mitotic spindle assembly

1999 • 349 citations

Disassembly of the nucleus in mitotic extracts: Membrane vesicularization, lamin disassembly, and chromosome condensation are independent processes

1987 • 349 citations

Interaction of the Nuclear GTP-Binding Protein Ran with Its Regulatory Proteins RCC1 and RanGAP1

1995 • 334 citations

THE NUCLEUS: STRUCTURE, FUNCTION, AND DYNAMICS

1987 • 333 citations

Nuclear pore complex contains a family of glycoproteins that includes p62: glycosylation through a previously unidentified cellular pathway.

1987 • 330 citations

MAN1, an Inner Nuclear Membrane Protein That Shares the LEM Domain with Lamina-associated Polypeptide 2 and Emerin

2000 • 329 citations

Rab GTPases, Directors of Vesicle Docking

1998 • 322 citations

The nuclear envelope and the architecture of the nuclear periphery.

1981 • 320 citations

Injected nuclei in frog oocytes: fate, enlargement, and chromatin dispersal

1976 • 305 citations

Self-Organization of Microtubule Asters Induced in Xenopus Egg Extracts by GTP-Bound Ran

1999 • 305 citations

Sperm decondensation in Xenopus egg cytoplasm is mediated by nucleoplasmin

1991 • 281 citations

Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.

1991 • 281 citations

Spontaneous formation of nucleus-like structures around bacteriophage DNA microinjected into Xenopus eggs

1983 • 279 citations

Roles of cytosol and cytoplasmic particles in nuclear envelope assembly and sperm pronuclear formation in cell-free preparations from amphibian eggs.

1984 • 254 citations

From nucleoporins to nuclear pore complexes

1997 • 243 citations

In vitro transport of a fluorescent nuclear protein and exclusion of non-nuclear proteins.

1986 • 211 citations

Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation.

1987 • 208 citations

Ypt1p implicated in v-SNARE activation

1994 • 199 citations

NUCLEAR ASSEMBLY

1997 • 195 citations

A Visual Screen of a Gfp-Fusion Library Identifies a New Type of Nuclear Envelope Membrane Protein

1999 • 176 citations

Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis

1999 • 167 citations

Assembly of the nuclear pore: biochemically distinct steps revealed with NEM, GTP gamma S, and BAPTA.

1996 • 165 citations

A distinct vesicle population targets membranes and pore complexes to the nuclear envelope in Xenopus eggs.

1991 • 149 citations

A trypsin-sensitive receptor on membrane vesicles is required for nuclear envelope formation in vitro.

1988 • 148 citations

Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts

1999 • 145 citations

Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression.

1994 • 139 citations

A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.

1994 • 138 citations

Spontaneous assembly of pore complex-containing membranes ("annulate lamellae") in Xenopus egg extract in the absence of chromatin.

1991 • 133 citations

GTP hydrolysis is required for vesicle fusion during nuclear envelope assembly in vitro.

1992 • 119 citations

RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus.

1996 • 118 citations

A role for ADP-ribosylation factor in nuclear vesicle dynamics

1992 • 110 citations

Characterization of the membrane binding and fusion events during nuclear envelope assembly using purified components.

1992 • 109 citations

RCC1, a Regulator of Mitosis, Is Essential for DNA Replication

1992 • 106 citations

A mutation in the RCC1-related protein pim1 results in nuclear envelope fragmentation in fission yeast.

1995 • 96 citations

Nuclear envelope assembly in Xenopus extracts visualized by scanning EM reveals a transport-dependent ‘envelope smoothing’ event

1997 • 75 citations

Nuclear envelope assembly after mitosis

1997 • 74 citations

Temporal Differences in the Appearance of NEP-B78 and an LBR-like Protein during Xenopus Nuclear Envelope Reassembly Reflect the Ordered Recruitment of Functionally Discrete Vesicle Types

1999 • 69 citations

[17] Catalysis of guanine nucleotide exchange or Ran by RCC1 and stimulation of hydrolysis of Ran-bound GTP by Ran-GAP1

1995 • 64 citations

The role of the Ran GTPase in nuclear assembly and DNA replication: Characterisation of the effects of Ran mutants

1998 • 56 citations

Nuclear assembly with lambda DNA in fractionated Xenopus egg extracts: an unexpected role for glycogen in formation of a higher order chromatin intermediate

1994 • 51 citations

The Balance of RanBP1 and RCC1 Is Critical for Nuclear Assembly and Nuclear Transport

1997 • 47 citations

RCC1, a regulator of mitosis, is essential for DNA replication.

1992 • 46 citations

GTP Hydrolysis Is Not Important for Ypt1 GTPase Function in Vesicular Transport

1998 • 44 citations

Lipophilic Organizing Structures of Sperm Nuclei Target Membrane Vesicle Binding and Are Incorporated into the Nuclear Envelope

1995 • 42 citations

Functional role of newly formed pore complexes in postmitotic nuclear reorganization

1989 • 36 citations

Reconstituting the nuclear envelope and endoplasmic reticulum

1996 • 22 citations

ARF is not required for nuclear vesicle fusion or mitotic membrane disassembly in vitro: evidence for a non-ARF GTPase in fusion.

1997 • 15 citations

Energy- and Temperature-Dependent In Vitro Export of RNA from Synthetic Nuclei

1997 • 10 citations